PLA- and PLA/PLGA-Emulsion Composite Biomaterial Sheets for the Controllable Sustained Release of Hydrophilic Compounds

Abstract

In the present study, by spin-coating a solution containing w/o (water-in-oil) emulsions and hydrophobic polymers, we obtained sheets possessing uniformly dispersed w/o emulsions. We performed release experiments for more than 100 days and clarified the effects of the number of layers, the sheet-forming polymers (polylactide (PLA), poly(lactic-co-glycolic acid (PLGA)), the ratio of organic solvent to water, and the composition of block copolymers on the release properties of the sheets. For a variety of sheets, we successfully achieved the sustained release of compounds from the sheets for 100–150 days. The sustained-release of compounds occurred because the compounds had to diffuse into polymer networks after their release from the emulsions. Interestingly, we observed an inflection point in the release profiles at around 50 days; that is, the sheet exhibited a “two-step” release behavior. The results obtained in the present study provide strong evidence for the future possibility of the time-programmed release of multiple compounds from sheets.

3D printed porous PLA/nHA composite scaffolds with enhanced osteogenesis and osteoconductivity in vivo for bone regeneration

“…This may be due to the addition of nHA. It is well known that PLA is a hydrophobic molecule [73], and the addition of nHA enhances certain hydrophilicity. For fat-soluble antibiotics, PLA may form a chemical bond with it, resulting in good adsorption.…”

PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites

“…Different materials designs include fibers, microparticles, nanoparticles, films, and porous scaffolds [3,4,5], and poly (lactic acid) and its copolymers with poly (glycolic acid). These are among the most used polyesters in medicine [6,7,8].…”

Acetic-Acid Plasma-Polymerization on Polymeric Substrates for Biomedical Application

“…Several researchers have found that hydrophilicity is an advantage for bioactive materials. It can improve cell attachment, spreading, and proliferation [29,30]. The water contact angle results of various polymeric substrates with different treatments are shown in Table 1.…”

“…Therefore, it is extremely interesting to monitor eventual alterations in surface morphology, as they are likely to considerably affect cell growth. In order to maintain a surface with a high level of hydrophilicity and functionality at the surface, subsequent modification by grafting of organic acid onto a plasma treated polymer was carried out [28,29,30,31]. Plasma polymerization has consequently proven highly successful as a means of developing functional interfaces for cell culture [27,32,33].…”