pKa Determination of Methaqualone

Zalipsky, J.J.; Patel, Dahyabhai M.; Darnowski, R.J.; Reavey-Cantwell, Nelson H.

doi:10.1002/jps.2600650342

Cited by 5 publications

(2 citation statements)

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“…Solutions of N ‐Gly‐CBZ (50 µM) were prepared in 25 mM phosphate buffers with pH values in the range of 5–12 and ionic strength adjusted to 0.15 with NaCl. UV–visible spectroscopy analysis was performed using a Varian Cary 50 Bio UV–Visible Spectrophotometer in the range of wavelengths between 200 and 400 nm to determine the p K a values of N ‐Gly‐CBZ by a method similar to that reported by Zalipsky et al38 The greatest change in the spectra with respect to pH was observed at the wavelength of 250 nm and the spectral change at this wavelength was used to determine p K a values.…”

Section: Methodsmentioning

confidence: 99%

Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine

Hemenway

Jarho

Henri

et al. 2010

Journal of Pharmaceutical Sciences

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Section: Methodsmentioning

confidence: 99%

Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine

Hemenway

Jarho

Henri

et al. 2010

Journal of Pharmaceutical Sciences

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“…72-44-6, C 16 H 14 N 2 O)) has a molecular weight of 250.3. It is a weak base with a p K a of 2.5 due to the ability of N1 to be protonated and become a hydrogen bond donor and has two hydrogen bond acceptors. , The calculated log P of methaqualone ( 1 ) has been reported to be 3.17 and 2.54 . The compound is typically produced as the free base or as the hydrochloride (HCl) salt (CAS no.…”

Section: Properties and Synthesismentioning

confidence: 99%

DARK Classics in Chemical Neuroscience: Methaqualone

Inger

Mihan

Kolli

et al. 2023

ACS Chem. Neurosci.

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Commonly known as “Quaaludes,” methaqualone (1) is a sedative–hypnotic medication, with effects resembling barbiturates and other downers, that exerts its effects through modulation of γ-aminobutyric acid type A receptors (GABAAR). Following the discovery of the sedative and euphoric effects of methaqualone (1), it was quickly adopted by pharmaceutical companies and promoted by clinicians around the world as a “safe” sleeping pill option, and for a period it was available over the counter. The popularity of methaqualone (1) soared worldwide, and many people began to use it recreationally for its sedative–hypnotic-like psychoactive effects. Not long after its introduction, many individuals began to misuse the drug leading to overdoses and drug dependence which brought to light methaqualone’s (1) addictive nature. In this review, the background, synthesis, pharmacology, metabolism, and pharmacokinetics of methaqualone (1) will be covered along with its discovery, history, and the derivatives that are currently available around the world through manufacture in clandestine laboratories.

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