PIXE characterization of tissues surrounding metallic prostheses coated with biological glasses

Electrochemical Anisotropy of Nanostructured Titanium for Biomedical Implants

“…This value is extremely small and is safely below the citotoxicity level of Ti, reported as 5 ppm [44].The respective corrosion rate for the basal planes of nanostructured Ti is estimated as ~1.65 g cm -2 year -1 or 0.03 g cm -2 week -1 . Usually, the released Ti is found in much larger concentrations in tissues at close distance to the implant (≤1000 m) than in blood or saliva (Table 6), therefore it is safe to assert that the release rate measured in this work improves various reported values [45][46][47][48][49] …”

Study of new sheep bone and Zn/Ca ratio around TiAlV screw: PIXE–RBS analysis

“…Generally, one can observe large differences in elemental loss induced by the irradiation. The most volatile elements are generally hydrogen and oxygen, whereas carbon and nitrogen are relatively stable [29,45]. In our case, the effect of irradiation damage is not pronounced, as no significant elemental loss was observed, even in case of light elements like C and O.…”

“…This suggests a modification of the chemical bonds (cross-linking, bonds scission), leading to the formation of volatile chemical products (most likely O 2 ). These chemical modifications result in the mass loss induced by the irradiation [29,45].…”

“…Examination of bone and osseointegration around an implant are frequently realized with techniques such as histological observation, histomorphometry, fluorescent microscopy and scanning electron microscopy [24][25][26][27]. RBS and PIXE analysis are complementary techniques for analysis of the implant-bone interface [28][29][30][31]. The advantages of PIXE analysis are the ability to make multiple-elemental maps with a good spatial resolution (in the order of lm) and to detect various trace elements simultaneously with good sensitivity [32].…”

Chemical imaging of the reconstruction of new bone and trace elements inside bioactive glass scaffolds in vivo: a multimodal and quantitative micro‐ion beam analysis

“…The amount of Zn, Sr and Mg traces is found to gradually increase from the implanted scaffold to native bone tissues. Zn is recognized as a coenzymatic factor and being used by several metalloenzymes for structure, catalytic or regulatory actions; the Zn content in bone tissues has been previously used as an indicator of the quality of bone formation . Sr ions are known for their osteoinductive properties that result in promotion of bone formation by a dual mode of action, stimulation of the bone‐forming osteoblasts cells and inhibition of bone resorbing osteoclasts cells .…”