Piwi-Interacting RNAs (piRNAs) Are Dysregulated in Renal Cell Carcinoma and Associated with Tumor Metastasis and Cancer-Specific Survival

Li, Yuping; Wu, Xiwei; Gao, Hanlin; Jin, Jennifer; Li, Arthur X.; Kim, Young S.; Pal, Sumanta K.; Nelson, Rebecca A.; Lau, Clayton M.; Guo, Chao; Mu, Bing; Wang, Jinhui; Wang, Frances; Wang, Jessica; Zhao, Yuqing; Chen, Wengang; Rossi, John J.; Weiss, Lawrence M.; Wu, Huiqing

doi:10.2119/molmed.2014.00203

Cited by 90 publications

(65 citation statements)

References 24 publications

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“…Both piR-932 and PIWIL2 could be potential targets for blocking the metastasis of breast cancer [81]. By deep sequencing 24 frozen benign kidney and clear cell renal cell carcinoma (ccRCC) specimens and using the publically available piRNA database, Li et al [82] found 19 piRNAs were differentially expressed between ccRCC and benign kidney tissue, and 46 piRNAs were associated with metastasis. Among these metastasis-related piRNAs, they found piR-32051, piR-39894 and piR-43607 were derived from the same piRNA cluster at chromosome 17, and were overexpressed in embryonic and neoplastic kidney cell lines compared to benign as well.…”

Section: Introductionmentioning

confidence: 99%

PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer

Han

Xia

et al. 2017

Cell Physiol Biochem

124

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P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the germline, but emerging evidence revealed that piRNAs are expressed in a tissue-specific manner among multiple human somatic tissue types as well and play important roles in transposon silencing, epigenetic regulation, gene and protein regulation, genome rearrangement, spermatogenesis and germ stem-cell maintenance. PIWI proteins were first discovered in Drosophila and they play roles in spermatogenesis, germline stem-cell maintenance, self-renewal, retrotransposons silencing and the male germline mobility control. A growing number of studies have demonstrated that several piRNA and PIWI proteins are aberrantly expressed in various kinds of cancers and may probably serve as a novel biomarker and therapeutic target for cancer treatment. Nevertheless, their specific mechanisms and functions need further investigation. In this review, we discuss about the biogenesis, functions and the emerging role of piRNAs and PIWI proteins in cancer, providing novel insights into the possible applications of piRNAs and PIWI proteins in cancer diagnosis and clinical treatment.

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Section: Introductionmentioning

confidence: 99%

PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer

Han

Xia

et al. 2017

Cell Physiol Biochem

124

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“…The generation of mature miR-NAs is a multi-step process that starts in the nucleus and ends in the cytoplasm. 98 PIWI-interacting RNA DQ594040 is one down-regulated piRNA in bladder cancer, and its overexpression can inhibit bladder cancer cell proliferation, colony formation and promote cell apoptosis through up-regulating TNFSF4 protein. II), while other pri-miRNAs are transcribed by RNA Pol.…”

Section: Microrna Smentioning

confidence: 99%

“…97 piR-32051, piR-39894 and piR-43607 were found up-regulated in kidney cancer tissues. 98 PIWI-interacting RNA DQ594040 is one down-regulated piRNA in bladder cancer, and its overexpression can inhibit bladder cancer cell proliferation, colony formation and promote cell apoptosis through up-regulating TNFSF4 protein. 99 As for CRC, piR-651 was found to be up-regulated in tumour tissues, which is associated with metastasis state.…”

Section: Microrna Smentioning

confidence: 99%

Small non‐coding RNA and colorectal cancer

Chen

Liu

2019

J Cellular Molecular Medi

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Colorectal cancer (CRC) is the third most common malignance. Although great efforts have been made to understand the pathogenesis of CRC, the underlying mechanisms are still unclear. It is now clear that more than 90% of the total genome is actively transcribed, but lack of protein‐coding potential. The massive amount of RNA can be classified as housekeeping RNAs (such as ribosomal RNAs, transfer RNAs) and regulatory RNAs (such as microRNAs [miRNAs], PIWI‐interacting RNA [piRNAs], tRNA‐derived stress‐induced RNA, tRNA‐derived small RNA [tRFs] and long non‐coding RNAs [lncRNAs]). Small non‐coding RNAs are a group of ncRNAs with the length no more than 200 nt and they have been found to exert important regulatory functions under many pathological conditions. In this review, we summarize the biogenesis and functions of regulatory sncRNAs, such as miRNAs, piRNA and tRFs, and highlight their involvements in cancers, particularly in CRC.

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“…Recently, our lab has also reported the expression of piRNAs in human brain, and Alzheimer's disease (AD)‐affected brain, epithelial ovarian cancer sub‐types and neuroblastoma . Further, aberrant expression of piRNAs has been documented in cancers such as breast, pancreas, lung, kidney, colorectal, cervical, head, neck, and gastric cancer . However, only a few piRNAs such as piR‐651, piR‐20365, piR‐021285, piR‐932, and piR‐823 have been intensively explored and validated in different cancers to decipher their role in oncogenesis .…”

Section: Introductionmentioning

confidence: 99%

“…11 Further, aberrant expression of piRNAs has been documented in cancers such as breast, pancreas, lung, kidney, colorectal, cervical, head, neck, and gastric cancer. [24][25][26][27][28][29][30] However, only a few piRNAs such as piR-651, piR-20365, piR-021285, piR-932, and piR-823 have been intensively explored and validated in different cancers to decipher their role in oncogenesis. 8,[31][32][33][34] Cheng et al reported that the expression of piR-823 in gastric cancer tissues was significantly lower compared to non-cancerous tissues and its increased expression inhibited growth of gastric cancer cells.…”

mentioning

confidence: 99%

Tumor suppressive activity of PIWI‐interacting RNA in human fibrosarcoma mediated through repression of RRM2

Das

Roy

Jain

et al. 2018

Molecular Carcinogenesis

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P‐element induced wimpy testis (PIWI)‐interacting RNAs (piRNAs) are a promising class of small regulatory RNAs, earlier believed to control transposable elements (TEs) activity in germlines are now reported in somatic and cancer cells. The aberrant expression of piRNAs has been documented in various cancers wherein they modulate tumorigenesis either as oncogenes or tumor suppressors by curbing target gene expression. However, there is no report yet on the association of piRNAs in fibrosarcoma, an early metastatic lethal tumor. For the first time, we reported a piRNA, piR‐39980 in fibrosarcoma and investigated its potential role in malignancy by employing several methods such as qRT‐PCR, MTT assay, transwell invasion and migration assay, wound healing assay, flow cytometric cell cycle analysis, Annexin V‐PE apoptosis assay, AO/EB dual staining assay, and chromatin condensation assay. We observed that piR‐39980 significantly attenuated proliferation, migration, invasion, and colony forming ability as well as induced apoptotic cell death of HT1080 fibrosarcoma cells when transiently overexpressed with its piRNA mimics. The dual luciferase reporter assay confirmed that piR‐39980 promotes apoptosis and inhibits proliferation in fibrosarcoma by repressing RRM2 through direct targeting at its 3′UTR through extensive sequence complementary binding, unlike microRNA targeting. In summary, this study revealed that piR‐39980 has a strong anti‐tumor effect and hence could be a promising RNA‐based therapeutic agent for the malignancy of fibrosarcoma.

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Piwi-Interacting RNAs (piRNAs) Are Dysregulated in Renal Cell Carcinoma and Associated with Tumor Metastasis and Cancer-Specific Survival

Cited by 90 publications

References 24 publications

PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer

PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer

Small non‐coding RNA and colorectal cancer

Tumor suppressive activity of PIWI‐interacting RNA in human fibrosarcoma mediated through repression of RRM2

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