2019
DOI: 10.1111/jcmm.14209
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Small non‐coding RNA and colorectal cancer

Abstract: Colorectal cancer (CRC) is the third most common malignance. Although great efforts have been made to understand the pathogenesis of CRC, the underlying mechanisms are still unclear. It is now clear that more than 90% of the total genome is actively transcribed, but lack of protein‐coding potential. The massive amount of RNA can be classified as housekeeping RNAs (such as ribosomal RNAs, transfer RNAs) and regulatory RNAs (such as microRNAs [miRNAs], PIWI‐interacting RNA [piRNAs], tRNA‐derived stress‐induced R… Show more

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Cited by 79 publications
(50 citation statements)
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“…Previous study have confirmed that miRNAs play key role in the progression of BCa 18 . The multiple effects exerted by miRNAs in BCa cells include the regulation of proliferative, apoptotic, autophagic, migratory, invasive, metastatic, epithelial-mesenchymal transition (EMT), angiogenic and drug resistant phenotypes 19 . Dysregulated miR-96-5p expression occurs in numerous cancers.…”
Section: Discussionmentioning
confidence: 99%
“…Previous study have confirmed that miRNAs play key role in the progression of BCa 18 . The multiple effects exerted by miRNAs in BCa cells include the regulation of proliferative, apoptotic, autophagic, migratory, invasive, metastatic, epithelial-mesenchymal transition (EMT), angiogenic and drug resistant phenotypes 19 . Dysregulated miR-96-5p expression occurs in numerous cancers.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, tRF/miR1280 suppressed colorectal cancer progression by repressing the Notch signaling that was important to CSCs. 73,74 Soares et al have examined the presence of tRFs, including 5 0 tRF-Lys TTT , 5 0 tRF-Val CAC , 5 0 tRF-Glu CTC and 5 0 tRF-Pro CGG that the 5 0 tRF-Val CAC level was slightly decreased in cancer cells, while it was significantly downregulated after transcatheter arterial infusion chemotherapy. 5 0 tRF-Glu CTC was decreased independently of transcatheter arterial infusion chemotherapy.…”
Section: Colorectal Cancermentioning
confidence: 99%
“…TRF-3 (13-22Nucleotide[nt]) can be further classified into tRF-3 and tRF-3b, while t-RF-5 can be classified into three subtypes: tRF-5a (14-16nt), tRF-5b (22-24nt) and tRF-5c (28-30nt) (16). TiRNAs are non-coding small RNAs with 31-40 nucleotides in length, which can be classified into 3'-tiRNAs and 5'-tiRNAs (11,(17)(18)(19)(20)(21). The type of tsRNAs was shown in Figure 1.…”
Section: Classification Of Trfs and Tirnasmentioning
confidence: 99%