Pivotal role of microRNA-9 in osteosarcoma tumorigenesis and tumor progression

Qi, Xiaojun; Wang, J.F.; Wang, G.D.; Xu, Qiang; Sun, Hai-hong

doi:10.4238/gmr.15017318

Cited by 8 publications

(6 citation statements)

References 32 publications

(19 reference statements)

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“…miR‐9 activation led to significantly increased cell motility by downregulating multiple gene targets involved in cell migration in cervical cancer . Similar results were observed in various types of cancers, such as osteosarcoma, ovarian cancer, and gastric cancer . The expression level of miR‐9 correlates with MYCN amplification, tumor grade, and metastatic status .…”

Section: Discussionsupporting

confidence: 70%

miR‐9 regulates ferroptosis by targeting glutamic‐oxaloacetic transaminase GOT1 in melanoma

Zhang¹,

Wu²,

Zhang³

et al. 2018

Molecular Carcinogenesis

134

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Ferroptosis is a recently recognized form of regulated cell death driven by lipid-based reactive oxygen species (ROS) accumulation. However, the molecular mechanisms of ferroptosis regulation are still largely unknown. Here we identified a novel miRNA, miR-9, as an important regulator of ferroptosis by directly targeting GOT1 in melanoma cells. Overexpression of miR-9 suppressed GOT1 by directly binding to its 3'-UTR, which subsequently reduced erastin- and RSL3-induced ferroptosis. Conversely, suppression of miR-9 increased the sensitivity of melanoma cells to erastin and RSL3. Importantly, anti-miR-9 mediated lipid ROS accumulation and ferroptotic cell death could be abrogated by inhibiting glutaminolysis process. Taken together, our findings demonstrate that miR-9 regulates ferroptosis by targeting GOT1 in melanoma cells, illustrating the important role of miRNA in ferroptosis.

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Section: Discussionsupporting

confidence: 70%

miR‐9 regulates ferroptosis by targeting glutamic‐oxaloacetic transaminase GOT1 in melanoma

Zhang¹,

Wu²,

Zhang³

et al. 2018

Molecular Carcinogenesis

134

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show abstract

“…Furthermore, in normal epithelial and breast cancer cells, miR-9-5p induces epithelial to mesenchymal transition by targeting E cadherin (CDH1) [39]. Recently, reducing miR-9-5p in an osteosarcoma cell line and identification of high levels of expression in primary tumors suggests a role for this miRNA in regulating the progression of osteosarcoma [55]. This role in osteosarcomas in addition to RMS described here, indicates a role for miR-9-5p in mesenchymal malignancies further to that previously described epithelial and neural cancers.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA and gene co-expression networks characterize biological and clinical behavior of rhabdomyosarcomas

et al. 2017

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Rhabdomyosarcomas (RMS) in children and adolescents are heterogeneous sarcomas broadly defined by skeletal muscle features and the presence/absence of PAX3/7-FOXO1 fusion genes. MicroRNAs are small non-coding RNAs that regulate gene expression in a cell context specific manner. Sequencing analyses of microRNAs in 64 RMS revealed expression patterns separating skeletal muscle, fusion gene positive and negative RMS. Integration with parallel gene expression data assigned biological functions to 12 co-expression networks/modules that reassuringly included myogenic roles strongly correlated with microRNAs known in myogenesis and RMS development. Modules also correlated with clinical outcome and fusion status. Regulation of microRNAs by the fusion protein was demonstrated after PAX3-FOXO1 reduction, exemplified by miR-9-5p. MiR-9-5p levels correlated with poor outcome, even within fusion gene positive RMS, and were higher in metastatic versus non-metastatic disease. MiR-9-5p reduction inhibited RMS cell migration. Our findings reveal microRNAs in a regulatory framework of biological and clinical significance in RMS.

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“…Knockdown of miR-29 induces apoptosis of osteosarcoma cells by regulating TGF-β1/PUMA signalling [ 68 ]. Upregulated miR-9 expression can increase cell proliferation, migration, and invasion as well as decrease the apoptotic ability of the cells [ 69 ]. miR-9 promotes cell growth by targeting the GCIP tumor suppressor in osteosarcoma [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs with prognostic significance in osteosarcoma: a systemic review and meta-analysis

et al. 2017

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IntroductionThis study aimed to elucidate the prognostic value of microRNAs (miRNAs) in patients with osteosarcoma.Materials and MethodsStudies were recruited by searching PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang data-bases (final search update conducted January 2017). Eligible studies were identified and the quality was assessed using multiple search strategies.ResultsA total of 55 articles that investigated the correlation between miRNA expression and either patient survival or disease recurrence in osteosarcoma was initially identified. Among these, 30 studies were included in the meta-analysis. The results of our meta-analysis revealed that elevated levels of miR-21, miR-214, miR-29, miR-9 and miR-148a were associated with poor prognosis in osteosarcoma. Additionally, downregulated miR-382, miR26a, miR-126, miR-195 and miR-124 expression indicated poor prognosis in osteosarcoma.ConclusionsmiRNAs may act as independent prognostic factors in patients with osteosarcoma and are useful in stratifying risk.

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Pivotal role of microRNA-9 in osteosarcoma tumorigenesis and tumor progression

Cited by 8 publications

References 32 publications

miR‐9 regulates ferroptosis by targeting glutamic‐oxaloacetic transaminase GOT1 in melanoma

miR‐9 regulates ferroptosis by targeting glutamic‐oxaloacetic transaminase GOT1 in melanoma

MicroRNA and gene co-expression networks characterize biological and clinical behavior of rhabdomyosarcomas

MicroRNAs with prognostic significance in osteosarcoma: a systemic review and meta-analysis

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