Pityrosporum Ovale Types Cultured From Normal and Seborrheic Subjects

Spoor, Herbert J.; Traub, Eugene F.; Bell, Melanie J.

doi:10.1001/archderm.1954.01540150069005

Cited by 23 publications

(4 citation statements)

References 8 publications

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“…Although this yeast has subsequently been described in the opening of the pilosebaceous unit [7] and in seborrhea capitis [11], we were unable to find further reference to its occurrence in comedones. The association of yeasts with comedones is not, for example, mentioned by Baer and Witten [1], Marples [8], Smith and Waterworth [10] or Shehadeli and Kligman [9].…”

Section: Discussionmentioning

confidence: 85%

A Comparison of the Flora of the Comedones of Acne Vulgaris and Comedones in Elderly People

Ganor¹,

Sacks²

1969

Dermatology

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Section: Discussionmentioning

confidence: 85%

A Comparison of the Flora of the Comedones of Acne Vulgaris and Comedones in Elderly People

Ganor¹,

Sacks²

1969

Dermatology

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“…Many studies have examined carriage rates in different populations and different age groups. However, early studies often found low carriage rates due to the limitations in sampling techniques and culture media (264,415,435). An extensive study of the distribution of Malassezia species at various sites on adults was carried out by Leeming et al (246), using an optimized culture medium (245) and a sampling method known to recover 98% of the surface skin flora (470).…”

Section: Distribution Of Malassezia Species On Normal Skinmentioning

confidence: 99%

“…Innumerable studies have sought to resolve the issue, focusing either on the microbiology of the condition or on the therapeutic efficacy of various antifungal preparations. In the early 1950s, both Martin-Scott (273) and Spoor et al (415) expressed reservations about the association of Malassezia with SD, since it was found on normal scalps as well as in patients with SD. Van Der Wyk and Hechemy (446) studied the effect on dandruff of inhibiting either the yeast or bacterial populations on the scalp and found that reduction of the yeast population correlated with a decrease in dandruff while inhibition of the bacterial population did not.…”

Section: Seborrheic Dermatitis and Dandruffmentioning

confidence: 99%

Immunology of Diseases Associated withMalasseziaSpecies

2002

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SUMMARY Malassezia species are members of the human cutaneous commensal flora, in addition to causing a wide range of cutaneous and systemic diseases in suitably predisposed individuals. Studies examining cellular and humoral immune responses specific to Malassezia species in patients with Malassezia-associated diseases and healthy controls have generally been unable to define significant differences in their immune response. The use of varied antigenic preparations and strains from different Malassezia classifications may partly be responsible for this, although these problems can now be overcome by using techniques based on recent work defining some important antigens and also a new taxonomy for the genus. The finding that the genus Malassezia is immunomodulatory is important in understanding its ability to cause disease. Stimulation of the reticuloendothelial system and activation of the complement cascade contrasts with its ability to suppress cytokine release and downregulate phagocytic uptake and killing. The lipid-rich layer around the yeast appears to be pivotal in this alteration of phenotype. Defining the nonspecific immune response to Malassezia species and the way in which the organisms modulate it may well be the key to understanding how Malassezia species can exist as both commensals and pathogens.

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“…[8][9] Materials and Methods Media.-Unless otherwise indicated, the Pityrosporum organisms were grown in a medi¬ um described earlier3 and which is called Lipophilic Organism Maintenance medium (LOM medium) : dehydrated Czapek-Dox broth, 35 gm; yeast extract (Difco), 2.5 gm; chloramphenicol, 50 mg; cycloheximide, 500 mg; Tween-20, 75 ml; distilled water (q.s. [8][9] Materials and Methods Media.-Unless otherwise indicated, the Pityrosporum organisms were grown in a medi¬ um described earlier3 and which is called Lipophilic Organism Maintenance medium (LOM medium) : dehydrated Czapek-Dox broth, 35 gm; yeast extract (Difco), 2.5 gm; chloramphenicol, 50 mg; cycloheximide, 500 mg; Tween-20, 75 ml; distilled water (q.s.…”

mentioning

confidence: 99%