Pituitary Gonadotropins and Ovarian Function in Adolescent Dysfunctional Uterine Bleeding

Fraser, I. S.; Michie, Eileen A.; Wide, Leif; Baird, D. T.

doi:10.1097/00006254-197406000-00022

Cited by 7 publications

(9 citation statements)

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“…Despite the fact that sufficient FSH was secreted to ensure folliculogenesis with mid-cycle estrogen levels, no LH surge occurred until the second cycle. A similar event has been noted in the dysfunctional uterine bleeding observed secondary to the anovulatory menstrual cycles of pubertal girls (Fraser et a/., 1973;Hansen eta/., 1975). It appears that although the initiation of sexual maturation is attributable to a hypothalamic GnRH message, the pituitary has an important role in modifying the CNS initiative from above and in developing appropriate responses to modulation of gonadal products from below.…”

Section: Pituitarysupporting

confidence: 64%

“…at., 1977). Similar secretion of estrogen in response to longer intervals of gonadotrophin secretion in the female occurs before menarche (Fraser et at., 1973;Hansen et a/., 1975). These alterations suggest that the gonad is readily responsive to gonadotrophins during the late prepubertal period and that an augmented secretion of gonadotrophins at puberty is relatively promptly translated into sex steroid secretion.…”

Section: Gonadsmentioning

confidence: 86%

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Neuroendocrine Control of the Onset of Puberty

Wierman

CrowleyJr.

1986

Postnatal Growth Neurobiology

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Section: Pituitarysupporting

confidence: 64%

Section: Gonadsmentioning

confidence: 86%

Neuroendocrine Control of the Onset of Puberty

Wierman

CrowleyJr.

1986

Postnatal Growth Neurobiology

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“…Although danazol is known to inhibit ovulation (Greenblatt et al, 1971 ;Wood et al, 1975) this in itself would not necessarily explain the dramatic suppression of menstrual blood loss caused by the drug. In any case, it is known that heavy menstrual loss can occur following both anovulatory cycles (Fraser et al, 1973;Van Look, 1976) and ovulatory cycles (Haynes et al, 1979).…”

mentioning

confidence: 99%

Effect of Danazol on Serum Gonadotrophins and Steroid Hormone Concentrations in Women With Menorrhagia

Chimbira¹,

Anderson²,

Cope³

et al. 1980

BJOG

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In 13 ovulatory women with objective evidence of menorrhagia (menstrual blood loss greater than 80 ml), danazol 400 mg given daily for 12 weeks suppressed ovulation as shown by absence of gonadotrophin peaks, low serum progesterone levels and flat basal body temperature recordings. Serum concentrations of luteinking hormone and follicle stimulating hormone were within the range found during the normal menstrual cycle but oestradiol concentrations tended to fall, reaching levels less than 100 pmol/l in some patients. Danazol treatment had no effect on levels of androstenedione or dehydroepiandrosterone and its sulphate. The presence or absence of cyclical bleeding on treatment, and the measured blood loss was unrelated to circulating oestradiol levels.

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“…This is why dysfunctional uterine bleeding is common in teenaged girls. In most of these cases there is no ovulation 12 . Lack of ovulation will lead to unopposed estrogen effect on the endometrium.…”

Section: Pathophysiology Of Dysfunctional Uterine Bleedingmentioning

confidence: 99%

Dysfunctional Uterine Bleeding

Deligeoroglou

1997

Annals of the New York Academy of Sciences

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Dysfunctional uterine bleeding (DUB) is a frequent gynecological problem during adolescence and the most frequent cause of urgent admission to the hospital over this period of life. In about 95% of cases it is caused by the late maturation of the hypothalamic-pituitary-ovarian axis (HPO), leading to anovulatory cycles. These adolescents lack the E2 positive feedback on LH. Thus, the continuous production of estrogen with endometrial stimulation is the basic cause of dysfunctional uterine bleeding. The initial step in the evaluation of DUB includes detailed clinical history, followed by complete physical examination. Laboratory tests should include coagulation profile, complete blood count with platelet evaluation, and sometimes a serum pregnancy test. The treatment of DUB is related to the severity of symptomatology with the objective of stopping bleeding and preventing recurrences. Modern hormonal and other medical therapies enable physicians to treat DUB effectively, regardless of the cause. Surgical treatment, such as dilatation and curettage, is rarely indicated in the adolescent patient. The importance of continued follow-up in DUB cases should be underlined, until stabilization of ovulatory menstrual cycles.

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Pituitary Gonadotropins and Ovarian Function in Adolescent Dysfunctional Uterine Bleeding

Cited by 7 publications

References 0 publications

Neuroendocrine Control of the Onset of Puberty

Neuroendocrine Control of the Onset of Puberty

Effect of Danazol on Serum Gonadotrophins and Steroid Hormone Concentrations in Women With Menorrhagia

Dysfunctional Uterine Bleeding

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