Pituitary Function After Treatment of Intracranial Tumours in Children

Growth and Endocrine Disorders Secondary to Cranial Irradiation

“…The first case of induced hypopituitarism and growth retardation in children after cranial radiation for a tumor distant from the hypothalamic-pituitary region was reported in 1966 (4), and was followed quickly by several other reports (5)(6)(7)(8)(9)(10)(11)(12). It soon became apparent that irradiation of the hypothalamus and the pituitary gland resulted in a high incidence of G H deficiency and growth retardation.…”

The Role of Growth Hormone in Stunted Head Growth after Cranial Irradiation

“…(Pediatr Res 22: 402-404,1987) Abbreviations CNS, central nervous system GH, growth hormone OFC, occipitofrontal circumference SDS, SD score cGy, centi-Geigy IGHD, isolated growth hormone deficiency Treatment of many brain tumors, distant from the hypothalamic-pituitary axis, and prophylaxis against CNS leukemia includes cranial irradiation. Although this approach has improved survival (1), long-term morbidity is increasingly recognized (1-6), notably from endocrine problems associated with damage to the hypothalamic-pituitary axis, most commonly resulting in GH deficiency (7). In addition, there is also impairment of intellectual functions in many of the survivors (1)(2)(3)(4)(5)(6).…”

Thyroid function in patients with benign and malignant breast disease

“…In the remaining patients blood was taken 24 h after surgery. Serum was stored at -20°C before measurement, by immunoassay, of serum TSH concentration (mU/l), serum triiodothyronine (T3) concentration (nM) and serum thyroxine (T4) concentrations (nM) as previously described (Shalet et al, 1975). The sensitivity of the TSH assay was 0 5 mU/l.…”