The Role of Growth Hormone in Stunted Head Growth after Cranial Irradiation

Clayton, Peter E.; Shalet, Stephen M; Price, David A.; Surtees, Robert; Pearson, D

doi:10.1203/00006450-198710000-00007

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…Head growth was not significantly impaired in any of the patient groups, although treatment included cranial irradiation in groups I , 2 and 4. Reduced head circumference has, however, been reported about 9 years after cranial irradiation (18). Possibly the radiation dose of 18-24 Gy in our patients was too low, or the follow up too short to show any significant changes.…”

Section: Sitting Height Armspan and Head Circumferencecontrasting

confidence: 57%

Longitudinal anthropometric study in children with acute lymphoblastic leukaemia

Tamminga¹,

Kamps²,

Drayer³

et al. 1992

Acta Paediatrica

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In four groups of patients with acute lymphoblastic leukaemia, anthropometric variables were investigated every 3 months for 2 years. Group 1 (n = 7) was treated with a high-risk protocol, group 2 (n = 13) with a standard-risk protocol including cranial irradiation, group 3 (n = 13) with a standard-risk protocol without cranial irradiation and group 4 (n = 8) was followed after completion of treatment. A height retardation of 0.4-0.6 SD was observed during therapy in groups 1-3. A catch-up of 0.5 SD was found in group 4. The retardation of armspan was significantly larger than the retardation of sitting height when groups 1-3 were taken together. Head circumference was not affected. The anthropometric variables reflecting nutritional status showed a growth above normal during and after treatment. Corticosteroid medication and not cranial irradiation is the most likely explanation for our findings.

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Section: Sitting Height Armspan and Head Circumferencecontrasting

confidence: 57%

Longitudinal anthropometric study in children with acute lymphoblastic leukaemia

Tamminga¹,

Kamps²,

Drayer³

et al. 1992

Acta Paediatrica

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“…[1][2][3] Case reports and clinical studies [4][5][6][7][8][9][10][11] have found global delays in all linear craniofacial dimensions. This generates the erroneous impression of a relatively large cranium.…”

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confidence: 99%

Craniofacial and acral growth responses in growth hormone-deficient children treated with growth hormone

Segal

Pescovitz

Schaefer

et al. 2004

The Journal of Pediatrics

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“…Di Maio et al [14] reported a catch-up of head circumference in 5 patients with hypopituitarism after 18 months of combined treatment with rhGH and thyroxine. Similarly, Clayton et al [15] found that rhGH increased head circumference in growth-hormone deficient children but not in patients with growth retardation after cranial irradiation. Anneren et al [16], while studying the effect of rhGH in Down syndrome, found a better growth of the head in a first report, but this was not confirmed in a second [17].…”

Section: Discussionmentioning

confidence: 91%

Growth hormone therapy in chronic renal failure induces catch-up of head circumference

Dyck

Proesmans

2001

Pediatric Nephrology

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Growth of head circumference was studied along with height, weight, and body mass index (BMI) in 21 prepubertal patients with chronic renal failure (CRF) before and during recombinant human growth hormone (rhGH) treatment. CRF was present from birth in 15 patients, in the 6 others it was acquired and existing for at least 1 year. Five patients were on chronic dialysis, and 16 children were on conservative treatment with a median glomerular filtration rate of 17 ml/min per 1.73 m2 at the start of rhGH therapy. rhGH was administered for 12 months in all patients, for 18 months in 19, and for 24 months in 12 patients. Mean height standard deviation score (SDS) increased significantly from -2.29 to -1.31 after 1 year and to -1.07 after 2 years. Mean BMI SDS was within the normal range throughout. Mean head circumference SDS improved significantly from -2.04 to -1.45 after 1 year and remained stable thereafter. Changes in head circumference differed between patients under 5 years and those over 5 years. In the former, the increase in head circumference SDS was already significant after 6 months of therapy, in the latter, significance was reached only after 1 year. It can be concluded that rhGH in CRF patients significantly improves head circumference SDS, albeit not to the same extent as height SDS.

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The Role of Growth Hormone in Stunted Head Growth after Cranial Irradiation

Cited by 7 publications

References 12 publications

Longitudinal anthropometric study in children with acute lymphoblastic leukaemia

Longitudinal anthropometric study in children with acute lymphoblastic leukaemia

Craniofacial and acral growth responses in growth hormone-deficient children treated with growth hormone

Growth hormone therapy in chronic renal failure induces catch-up of head circumference

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