Pituitary Adenomas Associated with Elevated Blood Follicle-Stimulating Hormone Levels: A Histologic, Immunocytologic, and Electron Microscopic Study of Two Cases

Kovács, Kálmán; Horváth, Éva; Loon, Glen R. Van; Rewcastle, N. B.; Ezrin, Calvin; Rosenbloom, A.A.

doi:10.1016/s0015-0282(16)43333-9

Cited by 52 publications

(14 citation statements)

References 21 publications

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“…There are few reports providing evidence that the gonadotrophins derive from the tumour (Woolf & Schenk, 1974;Friend et al, 1976;Snyder & Sterling, 1976;Demura et al, 1977;Kovacs et al, 1978;Trouillas er al., 1981). In addition we are unaware of any previous reports of the effect of LHRH and TRH on cultured human pituitary tumour cells, although the basal release of FSH and/or LH by tumour cells in culture has been demonstrated (Kohler et al, 1969;Synder & Sterling, 1976;Demura et al, 1977).…”

Section: Discussionmentioning

confidence: 99%

Gonadotrophin and Alpha Subunit Secretion by Human ‘Functionless’ Pituitary Adenomas in Cell Culture: Long Term Effects of Luteinizing Hormone Releasing Hormone and Thyrotrophin Releasing Hormone

Surmont

Winslow

Loizou

et al. 1983

Clinical Endocrinology

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The long-term effects of LHRH and TRH on gonadotrophin alpha subunit, FSH and LH secretion by cell cultures of four human chromophobic pituitary tumours have been examined. The tumours derived from one male and three female patients who presented because of visual disturbance but had no evident endocrine symptoms. Subsequent serum hormone analysis showed the FSH to be high in the male but low or normal in the post-menopausal females whereas LH levels were low in all patients. In culture, basal hormone secretion could be maintained for periods up to 63 d. All tumours secreted alpha subunit and FSH, but much lower amounts of LH. Addition of LHRH or TRH for a period of 12 to 41 d showed that alpha subunit, FSH and LH secretion were stimulated by LHRH from one tumour, by LHRH and TRH from two tumours. There was always a rapid decline in the LH secretion. The tumour which secreted FSH predominantly was stimulated by TRH. We conclude that human pituitary 'functionless' adenomas can secrete gonadotrophin alpha subunit and FSH in vitro and that secretion can be stimulated during long term releasing hormone experiments. LH secretion, however, cannot be maintained.

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Section: Discussionmentioning

confidence: 99%

Gonadotrophin and Alpha Subunit Secretion by Human ‘Functionless’ Pituitary Adenomas in Cell Culture: Long Term Effects of Luteinizing Hormone Releasing Hormone and Thyrotrophin Releasing Hormone

Surmont

Winslow

Loizou

et al. 1983

Clinical Endocrinology

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“…Since 1979Since -1980, with progress in immunocytochemistry [1][2][3], it has been known that most "clinically non-functioning" adenomas (chromophobe on classic histology) actually secrete gonadotropins or are gonadotroph pituitary adenomas. In 10% of cases, immunolabeling is negative ("null-cell adenoma").…”

mentioning

confidence: 99%

Management of clinically non-functioning pituitary adenoma

Chanson

Raverot

Castinetti

et al. 2015

Annales d'Endocrinologie

169

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Clinically NFPA is currently the preferred term for designing all the pituitary adenomas which are not hormonally active (in other words, not associated with clinical syndromes such as amenorrhea-galactorrhea in the context of prolactinomas, acromegaly, Cushing's disease or hyperthyroidism secondary to TSH-secreting adenomas). They account for 15-30% of pituitary adenomas. Diagnosis is usually made either in the context of mass effect due to a macroadenoma or, increasingly, fortuitously during imaging performed for some unrelated purpose; the latter case is known as pituitary incidentaloma. Surgery is indisputably indicated in case of tumoral syndrome, but other aspects of NFPA (hormonal work-up, follow-up, and especially postoperative follow-up, management of remnant or recurrence, the special case of incidentaloma, or apoplexy) remain controversial. The French Endocrinology Society (SFE) therefore set up an expert working group of endocrinologists, neurosurgeons, ophthalmologists, neuroradiologists, pathologists and biologists to draw up guidelines, at the 2012 SFE Congress in Toulouse, France. The present article presents the guidelines suggested by this group of French-speaking experts.

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“…Of the 209 pituitary tumors in vestigated. 41 were classified as growth hormone cell adenomas (17 densely granulated and 24 sparsely granulated), 65 as prolactin cell adenomas (I densely granulated and 64 sparsely granulated), 12 as mixed adenomas, composed of growth hormone cells and prolactin cells, 9 were found to consist of acidophil stem cells [Horvath et at., 1977 b], 27 corresponded to corticotroph cell adenomas, 2 were FSH-secreting adenomas [Kovacs et at., 1978b], I was a TSH-secreting adenoma, 32 were considered to represent undif ferentiated cell adenomas, 11 were oncocytomas and 9 were unclassified.…”

Section: Methodsmentioning

confidence: 99%

“…Nelson's syndrome [Kovacs et at., 1976], or unaccompanied by enhanced ACTH secretion referred to as silent corticotroph cell adenoma [Kovacs et at.. 1978a]; (2) nontumorous hyperactive gonadotrophs from ovariectomized women [Kovacs amt Horvath. 1975], adenomatous gonadotrophs with FSH secretion [Kovacs et at.. 1978b] and nontumorous gonadotrophs from patients who have not undergone ovariectomy, and (3) nontumorous prolactin cells [von Lawzewitsch et at.. 1972] and sparsely granulated adenomatous prolactin cells associated with hypersecretion ,…”

Section: Methodsmentioning

confidence: 99%

Nuclear inclusions in the human adenohypophysis

D¹,

Horváth²,

Kovács³

1979

Cells Tissues Organs

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Electron microscopy revealed the presence of nonviral nuclear inclusions in human nontumorous as well as adenomatous adenohypophysiocytes, regardless of cell type. Based on ultrastructural appearances, the inclusions have been classified as simple bodies, complex bodies and filamentous aggregates. Many transitional forms were noted between the simple and complex bodies, however, no relationship between the nuclear bodies and filamentous aggregates was found. It can be concluded that the three types of inclusions are normal nuclear constituents. Since no accumulation of these structures was observed in cells associated with enhanced secretion it appears that they are not related to hormonal hyperactivity in the human adenohypophysis.

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Pituitary Adenomas Associated with Elevated Blood Follicle-Stimulating Hormone Levels: A Histologic, Immunocytologic, and Electron Microscopic Study of Two Cases

Cited by 52 publications

References 21 publications

Gonadotrophin and Alpha Subunit Secretion by Human ‘Functionless’ Pituitary Adenomas in Cell Culture: Long Term Effects of Luteinizing Hormone Releasing Hormone and Thyrotrophin Releasing Hormone

Gonadotrophin and Alpha Subunit Secretion by Human ‘Functionless’ Pituitary Adenomas in Cell Culture: Long Term Effects of Luteinizing Hormone Releasing Hormone and Thyrotrophin Releasing Hormone

Management of clinically non-functioning pituitary adenoma

Nuclear inclusions in the human adenohypophysis

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