1978
DOI: 10.1016/s0015-0282(16)43333-9
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Pituitary Adenomas Associated with Elevated Blood Follicle-Stimulating Hormone Levels: A Histologic, Immunocytologic, and Electron Microscopic Study of Two Cases

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1979
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Cited by 52 publications
(14 citation statements)
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“…There are few reports providing evidence that the gonadotrophins derive from the tumour (Woolf & Schenk, 1974;Friend et al, 1976;Snyder & Sterling, 1976;Demura et al, 1977;Kovacs et al, 1978;Trouillas er al., 1981). In addition we are unaware of any previous reports of the effect of LHRH and TRH on cultured human pituitary tumour cells, although the basal release of FSH and/or LH by tumour cells in culture has been demonstrated (Kohler et al, 1969;Synder & Sterling, 1976;Demura et al, 1977).…”
Section: Discussionmentioning
confidence: 99%
“…There are few reports providing evidence that the gonadotrophins derive from the tumour (Woolf & Schenk, 1974;Friend et al, 1976;Snyder & Sterling, 1976;Demura et al, 1977;Kovacs et al, 1978;Trouillas er al., 1981). In addition we are unaware of any previous reports of the effect of LHRH and TRH on cultured human pituitary tumour cells, although the basal release of FSH and/or LH by tumour cells in culture has been demonstrated (Kohler et al, 1969;Synder & Sterling, 1976;Demura et al, 1977).…”
Section: Discussionmentioning
confidence: 99%
“…Since 1979Since -1980, with progress in immunocytochemistry [1][2][3], it has been known that most "clinically non-functioning" adenomas (chromophobe on classic histology) actually secrete gonadotropins or are gonadotroph pituitary adenomas. In 10% of cases, immunolabeling is negative ("null-cell adenoma").…”
mentioning
confidence: 99%
“…Of the 209 pituitary tumors in vestigated. 41 were classified as growth hormone cell adenomas (17 densely granulated and 24 sparsely granulated), 65 as prolactin cell adenomas (I densely granulated and 64 sparsely granulated), 12 as mixed adenomas, composed of growth hormone cells and prolactin cells, 9 were found to consist of acidophil stem cells [Horvath et at., 1977 b], 27 corresponded to corticotroph cell adenomas, 2 were FSH-secreting adenomas [Kovacs et at., 1978b], I was a TSH-secreting adenoma, 32 were considered to represent undif ferentiated cell adenomas, 11 were oncocytomas and 9 were unclassified.…”
Section: Methodsmentioning
confidence: 99%
“…Nelson's syndrome [Kovacs et at., 1976], or unaccompanied by enhanced ACTH secretion referred to as silent corticotroph cell adenoma [Kovacs et at.. 1978a]; (2) nontumorous hyperactive gonadotrophs from ovariectomized women [Kovacs amt Horvath. 1975], adenomatous gonadotrophs with FSH secretion [Kovacs et at.. 1978b] and nontumorous gonadotrophs from patients who have not undergone ovariectomy, and (3) nontumorous prolactin cells [von Lawzewitsch et at.. 1972] and sparsely granulated adenomatous prolactin cells associated with hypersecretion ,…”
Section: Methodsmentioning
confidence: 99%