Nuclear inclusions in the human adenohypophysis

D, Ryder; Horváth, Éva; Kovács, Kálmán

doi:10.1159/000145131

Cited by 5 publications

References 13 publications

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Roncoroni Re‐Visited: The Neuronal Intranuclear Rodlet Comes of Age

Woulfe,

Munoz

2024

J of Comparative Neurology

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Despite myriad technological advances in neuroscience, the nervous system harbors morphological phenomena that continue to defy explanation. First described by the classical microscopists, including Santiago Ramon y Cajal, at the end of the 19th century, the neuronal intranuclear rodlet (INR) has mystified neurohistologists and microscopists for centuries. In this review article, we will provide an overview of the discovery of the INR as well as the subsequent attempts to elucidate its nature and functional significance. We outline our own studies of this structure over the past three decades, focusing on its elusive nature, its interactions with other nuclear organelles, and on disease‐related quantitative changes in Alzheimer's disease. We then describe our somewhat serendipitous discovery that these structures are filamentous aggregates of the nucleotide‐synthesizing metabolic enzyme inosine monophosphate dehydrogenase. The filamentation of metabolic enzymes to form mesoscale cellular structures called “rods and rings” or “cytoophidia” (Greek for “cellular snakes”) is a recently described phenomenon that remains to be systematically investigated in the nervous system. Thus, this review provides an intriguing historical juxtaposition in neuroscience, inculcating the neuronal INR, once a mere morphological curiosity, into one of the most rapidly evolving fields in contemporary cell biology.

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Roncoroni Re‐Visited: The Neuronal Intranuclear Rodlet Comes of Age

Woulfe,

Munoz

2024

J of Comparative Neurology

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Intranuclear inclusions in paramyxovirus-induced encephalitis: evidence for altered nuclear body differentiation

Oglesbee

1992

Acta Neuropathol

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Intranuclear inclusion bodies (INB) are frequently encountered in viral infections, where they are thought to be accumulations of viral particles. However, for RNA viruses replicating in the cytoplasm, this compartmentalization represents a paradox not consistent with the viral replication cycle. To define the basis for intranuclear paramyxoviral inclusion bodies in astrocytes, natural cases of canine distemper virus subacute encephalitis were examined by light and transmission electron microscopy, and by quantitative confocal immunofluorescence microscopy. Although INB were viral antigen positive, they were not composed of structurally recognizable paramyxoviral nucleocapsids. The structural basis for the INB was instead viral antigen-associated forms of nucleolar development known as nuclear bodies. Three variants of the light microscopic Cowdry type A INB were complex nuclear bodies, giant beaded nuclear bodies (sphaeridia), and nuclear body-associated granulofilamentous matrices. In the latter, the granulofilamentous matrix frequently filled the nucleus, resulting in a fourth morphological INB variant, and was associated with morphological evidence of nuclear degeneration. These findings suggest a novel mechanism of virus-induced cytopathology whereby intranuclear viral protein exerts deleterious effects upon nucleolar differentiation in infected cells and hence altered host cell RNA metabolism.

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Nucleus

Ghadially¹

1988

Ultrastructural Pathology of the Cell and Matrix

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Nuclear inclusions in the human adenohypophysis

Cited by 5 publications

References 13 publications

Roncoroni Re‐Visited: The Neuronal Intranuclear Rodlet Comes of Age

Roncoroni Re‐Visited: The Neuronal Intranuclear Rodlet Comes of Age

Intranuclear inclusions in paramyxovirus-induced encephalitis: evidence for altered nuclear body differentiation

Nucleus

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