Nucleus

Ghadially, F. N.

doi:10.1016/b978-0-407-01571-5.50008-2

Cited by 30 publications

(26 citation statements)

References 440 publications

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“…Previous investigations have shown that these granules contain calcium and inorganic phosphate [24]. When modest amounts of calcium ions are present, they are deposited in these granules; however, if a large increase in calcium occurs de novo, granule formation occurs [24]. The increased size and number of granules seen in DSA hearts as compared with DZX hearts would suggest that there is an increased accumulation of mitochondrial Ca 2+ in DSA hearts that is attenuated in DZX hearts.…”

Section: Commentmentioning

confidence: 88%

“…These granules are also present in DZX hearts, but are significantly smaller in size and significantly less numerous than those observed in DSA hearts. Previous investigations have shown that these granules contain calcium and inorganic phosphate [24]. When modest amounts of calcium ions are present, they are deposited in these granules; however, if a large increase in calcium occurs de novo, granule formation occurs [24].…”

Section: Commentmentioning

confidence: 99%

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Diazoxide amelioration of myocardial injury and mitochondrial damage during cardiac surgery

McCully

Wakiyama

Cowan

et al. 2002

The Annals of Thoracic Surgery

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Section: Commentmentioning

confidence: 88%

Section: Commentmentioning

confidence: 99%

Diazoxide amelioration of myocardial injury and mitochondrial damage during cardiac surgery

McCully

Wakiyama

Cowan

et al. 2002

The Annals of Thoracic Surgery

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“…Embryos in the control group showed development until substage three, which was not achieved by embryos exposed to TNFa. It is interesting to note that in the present study, though a population of morulae underwent differentiation into blastocysts, their development was significantly compromised after TNFa exposure in vitro, characterized by a loss of cell polarity in trophoblast cells, lack of mitochondrial maturity, and a higher occurrence of inter-blastomere space, intra-cytoplasmic vacuoles, lysosomes and lipofuscin and multivesicular bodies (Ghadially 1988). It appears that input from the immediate microenvironment can influence these processes (Neider et al 1987, Enders et al 1989.…”

Section: Discussionmentioning

confidence: 99%

Endometrial tumor necrosis factor α (TNFα) is a likely mediator of early luteal phase mifepristone-mediated negative effector action on the preimplantation embryo

Lalitkumar¹,

Sengupta²,

Ghosh³

2005

Reproduction

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Cytokines and growth factors are important mediators of progesterone-regulated endometrial receptivity and embryo development. Early luteal phase administration of a potent antiprogestin-like mifepristone to the rhesus monkey results in endometrial desynchrony, loss of embryo viability and implantation failure. In the present study, administration of mifepristone (2 mg/kg body weight, s.c.) on day 2 after ovulation resulted in a significant increase (P < 0.01) in the level of tumor necrosis factor a (TNFa) in glandular and vascular compartments of endometrium, and in endometrial secretion and luminal fluid on day 6 after ovulation in the rhesus monkey. There was an associated lag in embryonic development, characterized by delayed mitochondrial maturity, poorly developed junctional complexes, a relative absence of intra-cytoplasmic filaments and a high degree of intra-cellular degenerative features. Exposure of TNFa (0, 0.5, 5, 50 ng/ml) to preimplantation stage mouse embryos in vitro showed a dose-dependent arrest in growth and development at both morula and blastocyst stages along with ultrastructural features of degeneration similar to those observed in embryos collected from early luteal phase mifepristone-treated monkeys. The de novo synthesized and released proteins in terms of trichloroacetic acid precipitable 35 S by morulae and blastocysts in vitro showed a marked depression following exposure to TNFa compared with control embryos. Based on the above observation and the fact that preimplantation stage embryos express receptors for TNFa, we suggest that increased levels of TNFa in endometrial and luminal compartments around the time of uterine receptivity following early luteal phase administration of mifepristone adversely affect the growth and viability of preimplantation stage embryos.Reproduction (2005) 129 323-335

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“…In some of the ciliated cells, additional degenerated secretory granules are present in the supranuclear region. These degenerated granules show a reticulated electron-lucent content with an electron-dense marginal zone, sometimes resembling myelin [Ghadially, 1997] ( fig. 3, 6c).…”

Section: Cervixmentioning

confidence: 99%

Ultrastructural Changes in the Cervical Epithelium during the Estrous Cycle of the Marsupial <i>Monodelphis domestica</i> (Grey Short-Tailed Opossum)

Wick

Kress²

2002

Cells Tissues Organs

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Ultrastructural changes in the cervical epithelium related to the estrous cycle have been studied in the South American marsupial Monodelphis domestica. The two cervices protrude with prominent papillae into the sinus vaginalis. At times of simple columnar at others of more pseudostratified character consists of two types of cells, ciliated and secretory cells. The mucosal epithelium is uniform in its entire length and shows no division into an endo- and ectocervix. The mucosa of the cervix differs from the uterine endometrium. There are no glandular structures, but the luminal epithelium shows deep invaginations underlined by dense connective tissue. The most conspicuous changes include the height and the differentiation of the cervical epithelium which attains its maximum development during estrus, where secretory cells are fully packed with large secretory granules and ciliated cells are well developed. After extruding their granules, secretory cells may transform into ciliated cells, while ciliated cells show the phenomenon of deciliation in which cilia packets are shed into the cervical lumen. This transformation process takes place mainly during post- and metestrus. The presence of solitary cilia is only noticeable during pro-estrus, being in contrast to the uterine epithelium where they appear during the whole estrous cycle.

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Nucleus

Cited by 30 publications

References 440 publications

Diazoxide amelioration of myocardial injury and mitochondrial damage during cardiac surgery

Diazoxide amelioration of myocardial injury and mitochondrial damage during cardiac surgery

Endometrial tumor necrosis factor α (TNFα) is a likely mediator of early luteal phase mifepristone-mediated negative effector action on the preimplantation embryo

Ultrastructural Changes in the Cervical Epithelium during the Estrous Cycle of the Marsupial <i>Monodelphis domestica</i> (Grey Short-Tailed Opossum)

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