Pituitary Adenoma Pathogenesis: The Presence Of E-Cadherin and Its Influence on Tumor Invasiveness

Abstract

E-cadherin (ECAD) loss on cell surface is related to invasiveness, metastases and bad prognosis in several malignant tumors of epithelial origin. Pituitary adenomas are common and benign tumors; however, they can become aggressive and invade other tissues. The herein assessed research describe ECAD positivity in most pituitary adenomas, but the relation between ECAD and tumor invasiveness led to different results. Further research is needed in order to better understand the ECAD impact on tumor development.