Pituicytoma: A case report with literature revisited

Shenoy, Ashok K; Desai, Heena M; Mehta, Jay

doi:10.4103/0377-4929.118695

Cited by 6 publications

(2 citation statements)

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“…4 Grossly, pituicytomas are discrete, solid, well-circumscribed tumors with a firm rubbery texture; their size may reach several centimeters. Histopathologically, pituicytomas are characterized by a compact architecture of elongated bipolar spindle cells arranged in interlacing fascicles or a storiform pattern.…”

Section: Discussionmentioning

confidence: 99%

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Pituicytoma Coexisting With Corticotroph Hyperplasia

Guo

Kong

et al. 2016

Medicine

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Pituicytoma is a rare, low-grade glial neoplasm that arises in the neurohypophysis or infundibulum and usually presents as pituitary gland enlargement. They are often misdiagnosed as pituitary adenomas. Causes have varied for high serum adrenocorticotropic hormone level reported in a few patients with pituicytoma.We report a rare case of pituicytoma accompanied by corticotroph hyperplasia—a challenging diagnosis guided by clinical presentations, radiological signs, and biopsy.We present a case of pituicytoma with corticotroph hyperplasia in a 46-year-old woman with typical Cushing syndrome. Magnetic resonance imaging revealed a lesion in the sellar area with equal T1 and T2 signals and marked homogeneous enhancement. We present detailed analysis of the patient's disease course and review pertinent literature. Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal. Because of this, there is no need to conduct special ethic review and the ethical approval is not necessary.The patient underwent a surgical exploration and tumor resection through a trans-sphenoidal approach. Pathologic results revealed pituicytoma and corticotroph hyperplasia. As adrenocorticotropic hormone and cortisol levels did not decrease to normal, the patient received radiotherapy and recovered uneventfully. No recurrence was found over 8 years of follow-up.Pituicytoma is a rare type of sellar tumor. Pituicytomas in patients with Cushing syndrome are rarer still. To our knowledge, this is the first report of Cushing syndrome caused by corticotroph hyperplasia in a pituicytoma patient.

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Section: Discussionmentioning

confidence: 99%

“…3 The golden criteria of diagnosis for pituicytomas are histopathological and immunohistochemistry (IHC) examinations, since clinical manifestations and radiological features both are nonspecific. 4 …”

Section: Introductionmentioning

confidence: 99%