Primary tumors of the posterior pituitary: A systematic review

Guerrero-Pérez, Fernando; Marengo, Agustina Pia; Vidal, Noemí; Iglesias, Pedro; Villabona, Carles

doi:10.1007/s11154-019-09484-1

Cited by 36 publications

(40 citation statements)

References 153 publications

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“…On hormonal evaluation, she had high IGF1 levels and mild hyperprolactinemia (Table 1). In a recent extensive review including 69 patients with GCTs, Guerrero-Pérez et al found that hypopituitarism was the most common endocrine manifestation (45%), but gynecomastia, as seen in our patient (case 6), and DI were rare presentations (18). Both the patients in our cohort did not have DI pre-operatively.…”

Section: Granular Cell Tumorsupporting

confidence: 49%

“…Although small tumorlets are commonly found in autopsy studies, significant enlargement of GCTs to cause symptomatic presentation is rare (17). These patients generally present in fourth to fifth decades with symptoms of mass effect (18). However, one of our patients (case 6) presented early in adolescence period.…”

Section: Granular Cell Tumormentioning

confidence: 72%

“…Interestingly, hormonal hypersecretion syndrome (as in case 7) is a known but very rare feature of GCTs. In the series by Guerrero-Pérez et al, three patients with GCTs had hypercortisolism, while two had features of acromegaly (18). A co-existing adenoma or secretion of yet un-identified trophic factors by GCTs are the proposed underlying mechanisms for hormonal hypersecretion.…”

Section: Granular Cell Tumormentioning

confidence: 98%

“…Both patients in our series developed permanent DI post-operatively, while patient 7 expired in early post-operative period probably due to massive bleed. In their largest series, Guerrero-Pérez et al described post-operative DI in one-third of patients, while critical peri-operative bleeding was seen in 20% of patients with one reported death (18). The role of radiation therapy and any other adjuvant therapies in these tumors is not well established.…”

Section: Granular Cell Tumormentioning

confidence: 99%

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Sellar surprises: a single-centre experience of unusual sellar masses

Thakkar¹,

Ramteke-Jadhav²,

Kasaliwal

et al. 2020

Endocrine Connections

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Background Most common incidentally detected sellar-suprasellar region (SSR) masses are pituitary adenomas, followed by craniopharyngioma, rathke’s cleft cyst, hypophysitis, and meningioma. Besides these, certain unusual SSR lesions can sometimes present as diagnostic challenges, where diagnosis is often made post-operatively on histopathology, the pre-operative suspicion of which might have influenced the management strategies. Series describing such masses are few. Objective To present clinical, biochemical, and radiological characteristics and management outcomes of rare SSR lesions other than pituitary adenomas, craniopharyngioma, rathke’s cleft cyst, hypophysitis, and meningioma. Design, setting, patients Retrospective case record analysis of patients with uncommon SSR masses (from January 2006 to December 2016). Results Our series consisted of ten patients, five with neoplastic and five with non-neoplastic lesions. Neoplastic masses included granular cell tumor (n = 2), astrocytoma (n = 1), malignant peripheral nerve sheath tumor (MPNST, n = 1), and metastasis from occult papillary carcinoma of thyroid (n = 1), while non-neoplastic masses were aspergillus abscess (n = 1), sterile abscess (n = 1), and tubercular abscess (n = 1), aneurysm of left internal carotid artery (n = 1), and ruptured dermoid cyst (n = 1). All patients (except one) presented with headache and/or visual disturbance. Only one patient had acromegaly while most others had hypopituitarism. We describe detailed MRI characteristics of each of the lesion. Seven patients underwent trans-sphenoidal surgery. Post-operatively, five patients had permanent diabetes insipidus, while two patients died in early post-operative period. Conclusion Our series expand the differential diagnostic considerations of SSR lesions. Most of the rare SSR masses present with symptoms of mass effects and hypopituitarism. Except for some non-neoplastic lesions like sellar abscesses, aneurysms, and dermoid cysts which can have some specific imaging characteristics that can provide clue to pre-operative diagnosis, most of the other neoplastic masses have overlapping radiological features, and pre-operative suspicion remains difficult.

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Section: Granular Cell Tumorsupporting

confidence: 49%

Section: Granular Cell Tumormentioning

confidence: 72%

Section: Granular Cell Tumormentioning

confidence: 98%

Section: Granular Cell Tumormentioning

confidence: 99%

See 2 more Smart Citations

Sellar surprises: a single-centre experience of unusual sellar masses

Thakkar¹,

Ramteke-Jadhav²,

Kasaliwal

et al. 2020

Endocrine Connections

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“…PA is a benign tumor, which accounts for about 10% of intracranial tumors [15]. Because of the special biological morphology and behavior of PA, it is difficult to completely remove the tumor, which leads to a high recurrence rate of the tumor after surgery [16].…”

Section: Discussionmentioning

confidence: 99%

COL6A6 interacted with P4HA3 to suppress the growth and metastasis of pituitary adenoma via blocking PI3K-Akt pathway

Long

Liu

et al. 2019

Aging

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The role and mechanism of collagen type VI alpha 6 (COL6A6) on tumor growth and metastasis in pituitary adenoma (PA) was determined. COL6A6 was downregulated in PA tissues and cell lines, which was negatively associated with the expression of prolyl-4-hydroxylase alpha polypeptide III (P4HA3) in the progression of PA. Overexpression of COL6A6 significantly suppressed tumor growth and metastasis capacity in PA. In addition, P4HA3 worked as the upstream of the PI3K-Akt pathway to alleviate the antitumor activity of COL6A6 on the growth and metastasis of both AtT-20 and HP75 cells. Furthermore, the inhibitory effect of COL6A6 on cell proliferation, migration and invasion, and epithelial-mesenchymal transition (EMT) was reversed by P4HA3 overexpression or activation of the PI3K-Akt pathway induced by IGF-1 addition, which provided a new biomarker for clinical PA treatment.

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Tumors of the Sellar Region

Lacruz

2023

Central Nervous System Tumors

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Primary tumors of the posterior pituitary: A systematic review

Cited by 36 publications

References 153 publications

Sellar surprises: a single-centre experience of unusual sellar masses

Sellar surprises: a single-centre experience of unusual sellar masses

COL6A6 interacted with P4HA3 to suppress the growth and metastasis of pituitary adenoma via blocking PI3K-Akt pathway

Tumors of the Sellar Region

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