Pitfalls of assessment of autonomic function by heart rate variability

Hayano, Junichiro; Yuda, Emi

doi:10.1186/s40101-019-0193-2

Cited by 214 publications

(175 citation statements)

References 71 publications

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“…In the current pilot study, using novel proximity tagging technology, we show that stress index was lower, and HRV parameters (SDNN, rMSSD, HF) were higher when caregivers were in the presence of their dogs and inactive (lying, sitting, standing combined), as well as when in the presence of their dogs while sitting, vs. away from their dogs, over a 24-hr period. We also show that rMSDD and HF, two HRV parameters often reported in human-animal interaction research, were affected by body position, supporting the recommendation that posture, along with activity level, should be taken into consideration while measuring long-term HRV [33].…”

Section: Discussionsupporting

confidence: 79%

Effects of Proximity between Companion Dogs and Their Caregivers on Heart Rate Variability Measures in Older Adults: A Pilot Study

Ortmeyer

Katzel

2020

IJERPH

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Heart rate variability (HRV) is a noninvasive tool used to evaluate autonomic nervous system function and is affected by age, stress, postural changes, and physical activity. Dog ownership has been associated with higher 24-hr HRV and increased physical activity compared to nonowners. The current pilot study was designed to evaluate the effects of proximity to a dog in real time (minute-by-minute) on older dog caregivers’ HRV measures and stress index during normal daily life over a 24-hr period. Eleven caregivers (56–83 years of age) wore ActiGraph GT9X Link accelerometers and camntech electrocardiogram monitors, and 11 dogs wore PetPace Collars and ActiGraph monitors to determine (a) proximity (absence or presence of Received Signal Strength Indicator, RSSI), (b) heart rate and HRV measures, (c) position (lying vs. sitting vs. standing), and (d) physical activity in the 11 dyads. Twenty-four hour HRV (SDNN index) and physical activity in the caregivers and dogs were related. Stress index was lower, and HRV parameters (SDNN, rMSDD, high frequency power (HF)) were higher when an RSSI signal was detected (presence of dog) compared to no RSSI signal (absence of dog) in the caregivers while inactive (lying + sitting + standing combined). HRV parameters (rMSDD and HF) were lower in the caregivers while standing and sitting compared to lying. The results from this pilot study support the hypothesis that spending time in the presence of a companion dog increases caregivers’ HRV throughout the day and suggest that proximity to a dog may contribute to overall improvements in 24-hr HRV and cardiac health in dog caregivers.

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Section: Discussionsupporting

confidence: 79%

Effects of Proximity between Companion Dogs and Their Caregivers on Heart Rate Variability Measures in Older Adults: A Pilot Study

Ortmeyer

Katzel

2020

IJERPH

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“…-ECG recorded connection; -Two static volume measurements using a dilution technique (normal breathing frequency: respiratory rate of 20-25/min): 5 min for each recording. These two measurements allowed the calculation of the static volumes as recommended (Wanger et al, 2005); -One functional residual capacity (FRC) measurement using a dilution technique with slow-paced breathing recording at six cycles per minute [5 s of inspiration, 5 s of expiration: 5 min as previously described (Garcia-Araújo et al, 2015)] in order to study respiratory sinus arrhythmia (RSA) that is recognized as a physiological mechanism to ensure optimal ventilation-perfusion matching within the lungs (Hayano and Yuda, 2019); -Exhaled NO measurement at multiple flow rates to calculate alveolar NO concentration (C alv,NO ) and maximal bronchial NO flux (J' aw,NO ) as previously described (Mahut et al, 2004). J' aw,NO has been correlated to both subepithelial eosinophilic infiltration and reticular basement membrane thickness, two asthma characteristics (Mahut et al, 2004).…”

Section: Pulmonary Function Tests and Hrv Analysismentioning

confidence: 99%

“…Lucini et al (2018) determined that the HRV variables can be classified in three independent factors that were used: oscillatory domain (HFnu, LFnu, LF/HF ratio, and possibly HFnu), amplitude domain (Ptot, HFa, and LFa) and a pulse domain (HR and mean RR). When HR fluctuations mediated by autonomic nerves are observed in HF band (>0.15 Hz), it is mediated by the cardiac vagus (Hayano and Yuda, 2019).…”

Section: Pulmonary Function Tests and Hrv Analysismentioning

confidence: 99%

Salbutamol Worsens the Autonomic Nervous System Dysfunction of Children With Sickle Cell Disease

et al. 2020

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Background: Sickle cell disease (SCD) patients with asthma have an increased rate of vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) episodes when compared to those without asthma. We hypothesized that either asthma diagnosis or bronchodilator treatment might aggravate SCD via their modulating effect on the autonomic nervous system (ANS). Methods: Cross-sectional evaluation of heart rate variability (HRV) during pulmonary function tests, including salbutamol administration, in children with SCD receiving asthma treatment or not when compared to asthmatic children without SCD matched for ethnicity. Results: SCD children with asthma (n = 30, median age of 12.9 years old) were characterized by a reduced FEV 1 /FVC ratio, an increased bronchodilator response, and a greater incidence of VOC and ACS when compared to SCD children without asthma (n = 30, 12.7 years). Children with asthma without SCD (n = 29, 11.4 years) were characterized by a higher exhaled NO fraction than SCD children. SCD children when compared to non-SCD children showed reduced HRV [total power, low (LF) and high (HF, vagal tone) frequencies], which was further worsened by salbutamol administration in all the groups: reduction in total power and HF with an increase in LF/HF ratio. After salbutamol, the LF/HF ratio of the SCD children was higher than that of the non-SCD children. The two groups of SCD children were similar, suggesting that asthma diagnosis per se did not modify ANS functions. Conclusion: SCD children are characterized by impaired parasympathetic control and sympathetic overactivity that is worsened by salbutamol administration.

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“…For an exhaustive explanation of all the common HRV metrics, their calculation, meaning, and clinical use, we referred to the study by Shaffer et al, Hayano et al and the guidelines of the task force of the European society of cardiology and the North American society of pacing and electrophysiology (Hayano & Yuda, 2019; "Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology," 1996;F.…”

Section: Hrvmentioning

confidence: 99%

Heart rate regulation in patients with anorexia nervosa

Baumann¹,

Willaschek²,

Buchhorn³

2019

Preprint

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Objective: The purpose of this investigation was to examine heart rate variability (HRV), interbeat interval (IBI), and their interrelationship in healthy subjects, bradycardic HCN4 mutation carriers, and patients with anorexia nervosa (AN). We hypothesized that bradycardia in patients with AN is caused by neural mechanisms. Therefore, we assumed that a saturation effect of the HRV/IBI relationship in consequence of sustained parasympathetic control of the sinus node is exclusively detectable in patients with AN. Method: Patients with AN between the ages of 12 and 16 years admitted to our hospital due to malnutrition were grouped (N = 20). A matched-pair group with healthy children and adolescents was created. Groups were matched for age and gender. We performed 24-hour Holter electrocardiography (ECG) in controls and patients. Specifically, all patients underwent two 24-hour Holter ECGs (admission; refeeding treatment). Additionally, IBI's were recorded during night-time in HCN4 mutation carriers (N = 4). HRV parameters were analyzed in 5-minute sequences during night-time and plotted against mean corresponding IBI length. HRV, IBI, and their interrelationship were examined by calculating saturation indices, Spearman's rank correlation analyses, Mann-Whitney U-and Wilcoxon signed-rank tests. Results:The relationship between IBI and HRV showed signs of saturation in patients with AN. Signs of HRV saturation were also present in two HCN4 mutation carriers. In contrast, signs of HRV saturation were barely present in controls. Discussion:We believe that non-neural mechanisms such as HCN4 down-regulation are possible explanations for HRV saturation and the associated bradycardia in patients with AN.

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Pitfalls of assessment of autonomic function by heart rate variability

Cited by 214 publications

References 71 publications

Effects of Proximity between Companion Dogs and Their Caregivers on Heart Rate Variability Measures in Older Adults: A Pilot Study

Effects of Proximity between Companion Dogs and Their Caregivers on Heart Rate Variability Measures in Older Adults: A Pilot Study

Salbutamol Worsens the Autonomic Nervous System Dysfunction of Children With Sickle Cell Disease

Heart rate regulation in patients with anorexia nervosa

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