Pitfalls in Interpreting Serum Creatine Phosphokinase Activity

The immediate changes in serum potassium and calcium and 2 4 h changes in creatine kinase (CK) following suxamethonium administration were compared in children undergoing strabismus repair or tonsillectomy following induction of anaesthesia with thiopentone or halothane. A separate group of children were anaesthetized with isoflurane and did not receive suxamethonium.There was a sigruficant increase (P < 0.05) in serum potassium of 0.26 and 0.56 mmol.l-' following halothane-suxamethonium induction and a sigruficant decrease ( P < 0.05) of 0.35 and 0.13 mmol.1-' after thiopentone-suxamethonium induction in the strabismus and tonsillectomy groups respectively. There was an increase in the 24 h CK values of 624 and 694 u.1-I (P < 0.05) in patients receiving halothane-swamethonium induction and of 43 (NS) and 247 u.1-I (P < 0.05) in patients receiving thiopentone-suxamethonium induction in the strabismus and tonsillectomy groups respectively. Suxamethonium administration was associated with a small but sometimes sigruficant ( P < 0.05) decrease in total serum calcium concentrations (0.036 to 0.049 mmol-1-'). Changes in all indices were minimal in children anaesthetized with isoflurane. It is concluded that the administration of halothane and suxamethonium is the main cause for the changes in serum potassium and CK and not the presence of strabismus.

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“…premeditation, which in itself can raise serum CK levels. (Nevins, Madhukar & Bright 1973). No patients in the present study received i.m.…”

Section: Discussionmentioning

confidence: 76%

Changes in serum potassium, calcium and creatine kinase following suxamethonium administration in children with and without strabismus

McLoughlin

Mirakhur

Elliott

et al. 1991

Pediatric Anesthesia

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“…Moderate enzyme levels can be found in the intestines, uterus, urine bladder, or kidney. Low concentrations of CK are measured in the liver and erythrocytes [7,8]. Accordingly, damage of the skeletal muscle, heart, or brain are the most frequent causes of CK-elevation.…”

Section: Discussionmentioning

confidence: 99%

Significance of CK-elevation in noncompaction with regard to cardiac and neuromuscular disease

Finsterer

Stöllberger²,

Krugluger

2008

International Journal of Cardiology

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“…Elevation of serum CK was reported in only two patients with Sotos syndrome during status epilepticus. 22 Subclinical muscular rigidity, caused by frequent seizures, may be a contributing factor for the elevation of CK. 22 Spina bifida occulta, which is a cause of bladder dysfunction and VUR, was reported in three patients with Sotos syndrome.…”

Section: Case Reportmentioning

confidence: 99%

Sotos syndrome associated with complete ureteral duplication and bilateral vesicoureteral reflux

Motoyama

Arai

Ohara

et al. 2001

Clinical and Experimental Nephrology

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A 4-year-old boy with Sotos syndrome had repeated urinary tract infections. Complete right ureteral duplication and bilateral vesicoureteral reflux were, diagnosed, and antireflux surgery was performed. This child also had elevated serum creatine kinase levels and atypical absence seizures. The associations of ureteral duplication, continuously elevated serum creatine kinase level, and atypical absence seizure have not been reported previously in Sotos syndrome.

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Pitfalls in Interpreting Serum Creatine Phosphokinase Activity

Cited by 87 publications

References 46 publications

Changes in serum potassium, calcium and creatine kinase following suxamethonium administration in children with and without strabismus

Changes in serum potassium, calcium and creatine kinase following suxamethonium administration in children with and without strabismus

Significance of CK-elevation in noncompaction with regard to cardiac and neuromuscular disease

Sotos syndrome associated with complete ureteral duplication and bilateral vesicoureteral reflux

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