Piscidin: Antimicrobial peptide of rock bream, Oplegnathus fasciatus

Antimicrobial peptides from fish: beyond the fight against pathogens

“…c; Bae et al . ). Although their histidine‐rich structure should not provoke activity under physiological conditions, its richness in positive charges makes this family highly active (Campagna et al .…”

“…Including also dicentracin, epinecidin and myxindin in this group of α‐helical AMPs (Bae et al . ), which have been characterized in many different fish species (Table ). Most of these peptides are unstructured and acquire an α‐helical structure when in contact with lipid membranes (Tossi et al .…”

“…Depending on the infective bacteria, AMPs are expressed in different fish tissues (Bae et al . ; Umasuthan et al . ).…”

“…Phylogenetically, different peptides are representative of the same family as piscidins, such as pleurocidin, moronecidin and chrysophsin. Including also dicentracin, epinecidin and myxindin in this group of a-helical AMPs (Bae et al 2016), which have been characterized in many different fish species (Table 1). Most of these peptides are unstructured and acquire an ahelical structure when in contact with lipid membranes (Tossi et al 2000).…”

“…Most of these peptides are unstructured and acquire an ahelical structure when in contact with lipid membranes (Tossi et al 2000). Piscidins are cationic, linear, a-helical and amphipathic peptides with a high presence of phenylalanine, histidine and isoleucine residues in their composition (Masso-Silva & Diamond 2014;Zhuang et al 2017c;Bae et al 2016). Although their histidine-rich structure should not provoke activity under physiological conditions, its richness in positive charges makes this family highly active (Campagna et al 2007).…”