Piroxicam and other anti‐inflammatory oxicams

Lombardino, Joseph G.; Wiseman, Edward H.

doi:10.1002/med.2610020202

Cited by 49 publications

(17 citation statements)

References 31 publications

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“…The inhibitory effect of this agent on the induction of chemically induced colon tumors was studied in rats and mice. 15,16) Acarbose, an alpha-glycosidase inhibitor, acts to delay the intestinal absorption of carbohydrates, and hence, allows some passage of carbohydrates into the colon. It is effective for the treatment of type I and type II diabetes mellitus.…”

mentioning

confidence: 99%

Piroxicam and Acarbose as Chemopreventive Agents for Spontaneous Intestinal Adenomas in APC Gene 1309 Knockout Mice

Quesada

Kimata

Mori

et al. 1998

Japanese Journal of Cancer Research

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The use of nonsteroidal anti-inflammatory drugs has been suggested to have a chemopreventive effect against colon carcinoma, through the inhibition of cyclooxygenases 1 and 2, in patients with familial adenomatous polyposis and in animal models. Acarbose, an alpha-glycosidase inhibitor, may also be chemopreventive. In order to examine the effects of these drugs we employed APC gene knockout mice randomized into 3 groups, one for treatment with piroxicam (0.05% concentration in drinking water), one for acarbose (0.04% concentration in food) and another for the control. After 14 weeks of treatment, mice were killed for quantitation of gastric and intestinal adenomas. Tumor multiplicity in the whole gastrointestinal tract decreased from 33.89± ± ± ±13.07 Epidemiological studies indicate a marked decrease in the relative risk (40-50%) of colorectal cancer among continuous users of nonsteroidal anti-inflammatory drugs (NSAIDs) compared to those who do not take these agents.

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confidence: 99%

Piroxicam and Acarbose as Chemopreventive Agents for Spontaneous Intestinal Adenomas in APC Gene 1309 Knockout Mice

Quesada

Kimata

Mori

et al. 1998

Japanese Journal of Cancer Research

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“…Dihydro‐2 H ‐benzo[ b ][1,4]thiazine and their derivatives are one of the important class of heterocyclic compounds that exhibit a broad spectrum of bio‐ and pharmacological activities. Among several 1,2‐, 1,3‐, and 1,4‐benzothiazine compounds, the 1,4‐benzothiazines have been extensively studied because they show pronounced biological activities as antifungal agents (e.g., 1 ), the antihypertensive drug semotiadil ( 2 ), calcium antagonists 3 ,– antirheumatic agents 4 , adenosine triphosphate sensitive potassium (KATP) channel openers 5 , antihistamine agents 6 (Figure ), BK activators, cholinesterase inhibitors, chemosensitizers, anti‐inflammatory agents, antihypertensive agents, anticancer agents, antitumor agents, anti‐HIV agents, and so forth. Although some interesting routes are available for the synthesis of substituted dihydrobenzothiazines, efficient protocols for their diastereo‐ and enantioselective synthesis are still limited .…”

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confidence: 99%

A Synthetic Route to Chiral Dihydrobenzothiazines through Ring Opening of Activated Aziridines with 2‐Halothiophenols/Copper‐Powder‐Mediated C−N Cyclization

Ghorai

Sayyad

Nanaji

et al. 2015

Chemistry An Asian Journal

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“…Tolfenamic acid (TA) is a non-steroidal antiinflammatory drug (NSAID) of the fenamate group, which has been commonly used to reduce the pain and inflammation in different arthritic and postoperative conditions (Lombardino andWiseman 1982, Hawkey, 1999). It inhibits the biosynthesis of prostaglandins and also has an inhibitory action on prostaglandin receptors.…”

Section: Introductionmentioning

confidence: 99%

Effect of moxifloxacin administration on pharmacokinetics of tolfenamic acid in rats

Patel

Sadariya

Gothi

et al. 2011

Braz. arch. biol. technol.

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Pharmacokinetics of tolfenamic acid as a single drug (4 mg/kg, intramuscularly) and its co-administration with moxifloxacin (5 mg/kg, intramuscularly) in wistar rats were studied. The plasma drug concentration of tolfenamic acid was assayed by LC-MS/MS. Following intramuscular administration of tolfenamic acid as single drug and in combination with moxifloxacin in male rats, the mean values of observed peak plasma drug concentration (C max ), area under plasma drug concentration-time curve (AUC (0-∞) ), volume of distribution (Vz), half-life (t ½ ) and clearance (Cl) were 4111.44 ± 493.15 and 3837.69 ± 351.83 ng/ml, 20280.77 ± 3501.67 and 15229.18 ± 678.80 ng.h/ml, 822.17 ± 115.38 and 1249.64 ± 139.52 ml, 2.59 ± 0.16 and 3.27 ± 0.32 hr, and 218.39 ± 25.47 and 265.18 ± 11.36 ml/hr, respectively. The peak plasma drug concentration (C max ) was significantly higher in female rats compared to male rats. The volume of distribution (Vz) of the drug was significantly higher (P < 0.05) in moxifloxacin-treated male rats compared to female rats. Concomitant administration of moxifloxacin may alter the disposition of tolfenamic acid in male rats.

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Piroxicam and other anti‐inflammatory oxicams

Cited by 49 publications

References 31 publications

Piroxicam and Acarbose as Chemopreventive Agents for Spontaneous Intestinal Adenomas in APC Gene 1309 Knockout Mice

Piroxicam and Acarbose as Chemopreventive Agents for Spontaneous Intestinal Adenomas in APC Gene 1309 Knockout Mice

A Synthetic Route to Chiral Dihydrobenzothiazines through Ring Opening of Activated Aziridines with 2‐Halothiophenols/Copper‐Powder‐Mediated C−N Cyclization

Effect of moxifloxacin administration on pharmacokinetics of tolfenamic acid in rats

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