Piperine treating sciatica through regulating inflammation and MiR-520a/P65 pathway

Yu, Jiuwang; Li, Sha; Wang, Lu

doi:10.1016/s1875-5364(21)60040-7

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…In a clinical study, it was found that after the application of a herbal preparation containing piperine, knee osteoarthritis in patients was improved [ 23 ]. Pepper salt may also treat sciatica by modulating inflammation [ 24 ]. Ellagic acid is a polyphenol that is present in a variety of natural substances.…”

Section: Discussionmentioning

confidence: 99%

The mechanism by which Naru 3 pill protects against intervertebral disc cartilage endplate degeneration based on network pharmacology and experimental verification

Guo,

Xue,

et al. 2023

J Orthop Surg Res

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Context Naru 3 pill is a traditional Mongolian medicine for the treatment of intervertebral disc degeneration (IDD), but the mechanism is not yet clear. Objective This study investigated the mechanism of Naru 3 pill in the treatment of IDD. Materials and methods Active ingredients and related targets of Naru 3 pill, as well as IDD-related genes, were collected from public databases. The analysis was performed by protein‒protein interaction network analysis, gene ontology and Kyoto Gene and Genome Encyclopedia (KEGG) functional enrichment analysis, molecular docking and molecular dynamics simulations. Finally, the network pharmacology results were validated by in vitro experiments. Results Network analysis showed that sesamin, piperine and ellagic acid were potential key components and CASP3, BAX and BCL2 were key targets. KEGG analysis indicated the apoptotic pathway as a potential pathway. Molecular docking showed that sesamin interacted better with the targets than the other components. The results of molecular dynamics simulations indicated that the three systems BAX-sesamin, BCL2-sesamin and CASP3-sesamin were stable and reasonable during the simulation. In vitro experiments showed that sesamin had the least effect on cell growth and the most pronounced proliferation-promoting effect, and so sesamin was considered the key component. The experiments confirmed that sesamin had antiapoptotic effects and reversed the expression of CASP3, BAX and BCL2 in degeneration models, which was consistent with the network pharmacology results. Furthermore, sesamin alleviated extracellular matrix (ECM) degeneration and promoted cell proliferation in the IDD model. Conclusion The present study suggested that Naru 3 pill might exert its therapeutic and antiapoptotic effects on IDD by delaying ECM degradation and promoting cell proliferation, which provides a new strategy for the treatment of IDD.

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Section: Discussionmentioning

confidence: 99%

The mechanism by which Naru 3 pill protects against intervertebral disc cartilage endplate degeneration based on network pharmacology and experimental verification

Guo,

Xue,

et al. 2023

J Orthop Surg Res

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“…Specifically, piperine can promote the expression of miR-520a, which directly targets and inhibits the expression of P65, down-regulate pro-inflammatory factors IL-1β and TNF-α, while up-regulating the effects of anti-inflammatory factors IL-10 and TGF-β1. As a result, piperine may as a treatment for sciatica [ 45 ]. Duan et al suggested that piperine may have anti-inflammatory properties by regulating the key factors of the NF- κ B and MAPK signaling pathways [ 46 ].…”

Section: Bioactivities Of Piperine and Its Derivativesmentioning

confidence: 99%

Piperine: Chemistry and Biology

Han,

Zhang,

et al. 2023

Toxins

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Piperine is a plant-derived promising piperamide candidate isolated from the black pepper (Piper nigrum L.). In the last few years, this natural botanical product and its derivatives have aroused much attention for their comprehensive biological activities, including not only medical but also agricultural bioactivities. In order to achieve sustainable development and improve survival conditions, looking for environmentally friendly pesticides with low toxicity and residue is an extremely urgent challenge. Fortunately, plant-derived pesticides are rising like a shining star, guiding us in the direction of development in pesticidal research. In the present review, the recent progress in the biological activities, mechanisms of action, and structural modifications of piperine and its derivatives from 2020 to 2023 are summarized. The structure-activity relationships were analyzed in order to pave the way for future development and utilization of piperine and its derivatives as potent drugs and pesticides for improving the local economic development.

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“…Piperine was reported to exert anti-inflammatory activity by decreasing the expression of ICAM-1 on the macrophage surface thereby inhibiting macrophage polarization (Gholijani et al 2021). Piperine could suppress the pro-inflammatory factors IL-1β and TNF-α, and enhance the anti-inflammatory effects of IL-10 and TGF-β1 (Yu et al 2021). Though curcumin has several health benefits, one of the drawbacks is its poor bioavailability.…”

Section: Tab Ameliorated Lps-induced Apoptotic Markersmentioning

confidence: 99%

Anti-inflammatory potential of turmeric, amla, and black pepper mixture against sepsis-induced acute lung injury in rats

et al. 2022

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Piperine treating sciatica through regulating inflammation and MiR-520a/P65 pathway

Cited by 6 publications

References 30 publications

The mechanism by which Naru 3 pill protects against intervertebral disc cartilage endplate degeneration based on network pharmacology and experimental verification

The mechanism by which Naru 3 pill protects against intervertebral disc cartilage endplate degeneration based on network pharmacology and experimental verification

Piperine: Chemistry and Biology

Anti-inflammatory potential of turmeric, amla, and black pepper mixture against sepsis-induced acute lung injury in rats

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