Piperine: Chemistry and Biology

Han, Jin; Zhang, Shaoyong; He, Jun; Li, Tianze

doi:10.3390/toxins15120696

Cited by 4 publications

(2 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The structure of piperine comprises functional groups identified by the formation of reactive metabolites, namely a methylenedioxyphenyl (MDP) ring and conjugated alkene and piperidine portions [ 8 ]. Furthermore, the piperine molecule contains an oxymethylene ring, an aliphatic olefin chain and an amide group [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

Gusson-Zanetoni,

Cardoso,

de Sousa

et al. 2024

IJMS

View full text Add to dashboard Cite

Piperine, an active plant alkaloid from black pepper (Piper nigrum), has several pharmacological effects, namely antioxidant, anti-inflammatory and immunomodulatory effects, which involve inhibiting molecular events associated with various stages of cancer development. The aim of this study was to investigate the molecular mechanisms of action of piperine in relation to its potential anticancer effect on head and neck cancer cells. Parameters related to neoplastic potential and cytokine, protein and gene expression were investigated in head and neck cancer cell lines (HEp-2 and SCC-25) treated with piperine. The results of the tests indicated that piperine modified morphology and inhibited viability and the formation of cell colonies. Piperine promoted genotoxicity by triggering apoptosis and cell cycle arrest in the G2/M and S phases. A decrease in cell migration was also observed, and there was decreased expression of MMP2/9 genes. Piperine also reduced the expression of inflammatory molecules (PTGS2 and PTGER4), regulated the secretion of cytokines (IFN-γ and IL-8) and modulated the expression of ERK and p38. These results suggest that piperine exerts anticancer effects on tumor cells by regulating signaling pathways associated with head and neck cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

Gusson-Zanetoni,

Cardoso,

de Sousa

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Black pepper (Piper nigrum L.) is one of the most common spices in China and India. Piperine is a piperamide alkaloid isolated from the black pepper, with a content of approximately 2%-7.4% (Han, Zhang, et al, 2023). Piperine has demonstrated numerous pharmacological effects such as antitumor, antiangiogenesis, antioxidant, antidiabetic, anti-obesity, cardioprotective, and immunomodulatory effects in in vitro and in vivo experiments (Haq et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

In vitro modulation the Notch pathway by piperine: A therapeutic strategy for docetaxel‐resistant and non‐resistant prostate cancer

Wang,

Liu,

Sun

2024

Chem Biol Drug Des

View full text Add to dashboard Cite

Docetaxel (DTX) resistance poses a significant challenge in the treatment of prostate cancer (PCa), often leading to chemotherapy failure. This study investigates the ability of piperine, a compound derived from black pepper, to enhance the sensitivity of PCa cells to DTX and elucidates its underlying mechanism. We established a DTX‐resistant PCa cell line, DU145/DTX, to conduct our experiments. Through a series of assays, including MTT for cell viability, flow cytometry for apoptosis, Transwell for cell migration and invasion, and western blot for protein expression analysis, we assessed the effects of piperine on these cellular functions and on the Notch signaling pathway components. Our results demonstrated that we successfully established the DTX‐resistant PCa cell line DU145/DTX. Piperine effectively decreased the viability of both DU145 and its DTX‐resistant counterpart, DU145/DTX, in a concentration and time‐dependent manner when used alone and in combination with DTX. Notably, piperine also induced apoptosis and reduced the migration and invasion capabilities of these cells. At the molecular level, piperine down‐regulated the Notch pathway by inhibiting Notch1 and Jagged1 signaling, as well as reducing the expression of downstream effectors Hey1 and hes family bHLH transcription factor 1. The study concludes that piperine's ability to modulate the Notch signaling pathway and induce apoptosis highlights its potential as a complementary treatment for DTX‐resistant PCa, paving the way for the use of traditional Chinese medicinal compounds in modern oncology treatment strategies.

show abstract

Discovery of piperine derivatives as inhibitors of human dihydroorotate dehydrogenase to induce ferroptosis in cancer cells

Zhang,

Hong,

Fan

et al. 2024

Bioorganic Chemistry

View full text Add to dashboard Cite

Piperine: Chemistry and Biology

Cited by 4 publications

References 63 publications

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

In vitro modulation the Notch pathway by piperine: A therapeutic strategy for docetaxel‐resistant and non‐resistant prostate cancer

Discovery of piperine derivatives as inhibitors of human dihydroorotate dehydrogenase to induce ferroptosis in cancer cells

Contact Info

Product

Resources

About