2017
DOI: 10.1038/srep41066
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Abstract: This study characterizes the human metabolic response to piperine, a curcumin extract, and the details of its underlying molecular mechanism. Using 1H-NMR-based metabolome analysis, we showed the metabolic effect of piperine on skeletal muscle and found that piperine increased the level of intracellular lactate, an important metabolic intermediate that controls expression of several genes involved in mitochondrial activity. Piperine also induced the phosphorylation of AMP-activated protein kinase (AMPK) and it… Show more

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Cited by 45 publications
(25 citation statements)
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References 55 publications
(60 reference statements)
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“…Shotgun metagenomics sequencing analysis also showed that EODF upregulated the pathway of ‘Pyruvate fermentation to acetate and lactate by Lactobacillus reuteri ’ and ‘Pyruvate fermentation to acetate and lactate by unclassified bacteria’ (Figure S7). Intriguingly, recent studies indicate both acetate and lactate are beiging inducers (Hanatani et al, 2016; Kim et al, 2017; Sahuri-Arisoylu et al, 2016). In addition, both BAT and WAT express proton-linked monocarboxylate transporter 1 (MCT1) encoded by Mct1 , which drives acetate and lactate transport across the plasma membrane of adipocytes (den Besten et al, 2013; Iwanaga et al, 2009).…”
Section: Resultsmentioning
confidence: 97%
“…Shotgun metagenomics sequencing analysis also showed that EODF upregulated the pathway of ‘Pyruvate fermentation to acetate and lactate by Lactobacillus reuteri ’ and ‘Pyruvate fermentation to acetate and lactate by unclassified bacteria’ (Figure S7). Intriguingly, recent studies indicate both acetate and lactate are beiging inducers (Hanatani et al, 2016; Kim et al, 2017; Sahuri-Arisoylu et al, 2016). In addition, both BAT and WAT express proton-linked monocarboxylate transporter 1 (MCT1) encoded by Mct1 , which drives acetate and lactate transport across the plasma membrane of adipocytes (den Besten et al, 2013; Iwanaga et al, 2009).…”
Section: Resultsmentioning
confidence: 97%
“…The study on piperine effect to LPS-stimulated human epithelial-like SW480, and HT-29 cells showed that it downregulates the MAPK pathways [100]. Piperine stimulates the p38 MAPK and induces the phosphorylation of AMP-activated protein kinase [101]. The study of Kumar et al [102] found that piperine inhibits TNF-α, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin.…”
Section: Miscellaneous Activity-kinase Inflammation Diabetesmentioning
confidence: 99%
“…This occurs through intracellular redox modifications subsequent to its transport. The regulation of UCP1 expression by lactate has been confirmed by others (21,22). This mechanism might be part of a redox regulatory and adaptive loop (17,23) where a high redox (NADH/NAD + ) pressure drives UCP1 expression, just as mitochondrial ROS positively control UCP1 protein activity (24).…”
Section: Introductionmentioning
confidence: 74%