Piperine mitigates aortic vasculopathy in streptozotocin-diabetic rats via targeting TXNIP-NLRP3 signaling

Amin, Fatma Mohamed; Shehatou, George G S; Nader, Manar A.; Abdеlaziz, Rania R.

doi:10.1016/j.lfs.2022.121275

Cited by 5 publications

(2 citation statements)

References 62 publications

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“…Intriguingly, elevated levels of NLRP3 and IL-1β observed in patients with coronary artery disease exhibit an inverse association with the expression and protein levels of TXNIP and TRX1 [143]. Additionally, in a rat model of diabetes-associated aortic remodeling, the reduction of ROS levels improved TXNIP protein levels and prevented an increase in the mRNA levels of NF-κB, NLRP3, and IL-1β [144,145]. These findings underscore the critical role of ROS in inducing inflammatory activation through alterations in the TRX system.…”

Section: Nlrp3-nf-κb Pathway Activation In the Heart By Ckd-derived M...mentioning

confidence: 97%

Mitochondrial Impairment: A Link for Inflammatory Responses Activation in the Cardiorenal Syndrome Type 4

Amador-Martínez,

Aparicio-Trejo,

Bernabe-Yepes

et al. 2023

IJMS

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Cardiorenal syndrome type 4 (CRS type 4) occurs when chronic kidney disease (CKD) leads to cardiovascular damage, resulting in high morbidity and mortality rates. Mitochondria, vital organelles responsible for essential cellular functions, can become dysfunctional in CKD. This dysfunction can trigger inflammatory responses in distant organs by releasing Damage-associated molecular patterns (DAMPs). These DAMPs are recognized by immune receptors within cells, including Toll-like receptors (TLR) like TLR2, TLR4, and TLR9, the nucleotide-binding domain, leucine-rich-containing family pyrin domain-containing-3 (NLRP3) inflammasome, and the cyclic guanosine monophosphate (cGMP)–adenosine monophosphate (AMP) synthase (cGAS)–stimulator of interferon genes (cGAS-STING) pathway. Activation of these immune receptors leads to the increased expression of cytokines and chemokines. Excessive chemokine stimulation results in the recruitment of inflammatory cells into tissues, causing chronic damage. Experimental studies have demonstrated that chemokines are upregulated in the heart during CKD, contributing to CRS type 4. Conversely, chemokine inhibitors have been shown to reduce chronic inflammation and prevent cardiorenal impairment. However, the molecular connection between mitochondrial DAMPs and inflammatory pathways responsible for chemokine overactivation in CRS type 4 has not been explored. In this review, we delve into mechanistic insights and discuss how various mitochondrial DAMPs released by the kidney during CKD can activate TLRs, NLRP3, and cGAS-STING immune pathways in the heart. This activation leads to the upregulation of chemokines, ultimately culminating in the establishment of CRS type 4. Furthermore, we propose using chemokine inhibitors as potential strategies for preventing CRS type 4.

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Section: Nlrp3-nf-κb Pathway Activation In the Heart By Ckd-derived M...mentioning

confidence: 97%

Mitochondrial Impairment: A Link for Inflammatory Responses Activation in the Cardiorenal Syndrome Type 4

Amador-Martínez,

Aparicio-Trejo,

Bernabe-Yepes

et al. 2023

IJMS

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“…212 PIP exhibits significant potential by curbing kidney NLRP3 inflammasome, TXNIP expression, and inflammatory biomarkers in diabetic nephropathy, alongside normalizing blood parameters. 213,214 AGL exhibits promise with its antihyperlipidemic and antihyperglycemic effects, combatting low-density lipoprotein (LDL) oxidation while attenuating ROS production and NOX4 gene expression. 215,216 TRG emerges as a valuable asset, enhancing insulin sensitization and glucose utilization while reducing endoplasmic reticulum (ER) stress, OS, and TNF-α levels.…”

Section: Dietary Alkaloids In Mitigating Diabetic Complicationsmentioning

confidence: 99%

Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function

Alkanad,

Hani,

et al. 2024

BioFactors

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With the rising prevalence of diabetes and its association with cognitive impairment, interest in the use of dietary alkaloids and other natural products has grown significantly. Understanding how these compounds manage diabetic cognitive dysfunction (DCD) is crucial. This comprehensive review explores the etiology of DCD and the effects of alkaloids in foods and dietary supplements that have been investigated as DCD therapies. Data on how dietary alkaloids like berberine, trigonelline, caffeine, capsaicin, 1‐deoxynojirimycin, nuciferine, neferine, aegeline, tetramethylpyrazine, piperine, and others regulate cognition in diabetic disorders were collected from PubMed, Research Gate, Web of Science, Science Direct, and other relevant databases. Dietary alkaloids could improve memory in behavioral models and modulate the mechanisms underlying the cognitive benefits of these compounds, including their effects on glucose metabolism, gut microbiota, vasculopathy, neuroinflammation, and oxidative stress. Evidence suggests that dietary alkaloids hold promise for improving cognition in diabetic patients and could open exciting avenues for future research in diabetes management.

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Ranolazine ameliorates T1DM-induced testicular dysfunction in rats; role of NF-κB/TXNIP/GSDMD-N/IL-18/Beclin-1 signaling pathway

Samaha,

Nour

2024

European Journal of Pharmacology

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Piperine mitigates aortic vasculopathy in streptozotocin-diabetic rats via targeting TXNIP-NLRP3 signaling

Cited by 5 publications

References 62 publications

Mitochondrial Impairment: A Link for Inflammatory Responses Activation in the Cardiorenal Syndrome Type 4

Mitochondrial Impairment: A Link for Inflammatory Responses Activation in the Cardiorenal Syndrome Type 4

Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function

Ranolazine ameliorates T1DM-induced testicular dysfunction in rats; role of NF-κB/TXNIP/GSDMD-N/IL-18/Beclin-1 signaling pathway

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