Piper sarmentosum attenuates dexamethasone-induced hypertension by stimulating endothelial nitric oxide synthase

Ugusman, Azizah; Fadze, Noor Fazilah Md; Hamid, Adila A.; Asmawi, Zanariyah; Aminuddin, Amilia

doi:10.35333/jrp.2020.122

Cited by 8 publications

(25 citation statements)

References 20 publications

(36 reference statements)

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“…In male Wistar rats with Nωnitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertension, the aqueous leaf extract of PS (125, 250, and 500 mg/kg/day for 4 weeks) reduced systolic, diastolic, and mean arterial blood pressure [97]. Similar observations were obtained in dexamethasoneinduced [98,99] and spontaneously hypertensive rats treated with PS [24,100,101]. The hypotensive effect of PS could be attributed to its ability to increase vasodilation and decrease vasoconstriction.…”

Section: Effect Of Ps On Hypertensionmentioning

confidence: 73%

“…NO is a powerful vasodilator and its reduction can negatively impact endothelial-dependent vasodilation, leading to increased peripheral resistance and blood pressure [104]. The aqueous extract of PS increased the expression and activity of eNOS in the thoracic aorta, increased the serum level of eNOS and increased the levels of NO in the serum and mesenteric artery of L-NAME and dexamethasone-induced and spontaneously hypertensive rats [24,97,98,100,101]. This is suggestive of a vasodilatory effect of PS in hypertensive rats.…”

Section: Effect Of Ps On Hypertensionmentioning

confidence: 99%

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Effects of Piper sarmentosum on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence

2021

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Piper sarmentosum (PS) is a traditional medicinal herb used by South East Asians. It demonstrates promising properties against various non-communicable diseases and infectious agents due to its antioxidant and anti-inflammatory properties. Given that oxidative stress and inflammation are involved in developing and exacerbating metabolic syndrome (MetS) and its principal components (central obesity, hyperglycaemia, hypertension, and dyslipidaemia), PS could manage MetS and its complications. This review summarises the available literature on the effects of PS on principal components of MetS and their complications. The accumulated evidence suggests that PS prevented adiposity, hyperglycaemia, hypertension, and dyslipidaemia in preclinical studies mainly through its antioxidant and anti-inflammatory properties. It also protected against MetS-associated cardiovascular complications. This review has identified research gaps in this field and suggested future studies to guide interested researchers to explore further or affirm the therapeutic potential of PS. One of the most significant challenges to the medical use of PS is the absence of randomised controlled trials in humans. This study gap must be bridged before PS supplementation could be used to manage MetS in humans.

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Section: Effect Of Ps On Hypertensionmentioning

confidence: 73%

Section: Effect Of Ps On Hypertensionmentioning

confidence: 99%

Effects of Piper sarmentosum on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence

2021

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“…As for the preclinical studies, 12 studies involved animal models ( Peungvicha et al, 1998 ; Thent et al, 2012a ; Thent et al, 2012b ; Hussan et al, 2013 ; Luangpirom et al, 2014 ; Mohd Zainudin et al, 2015 ; Thent and Das, 2015 ; Alwi et al, 2018 ; Mohd Zainudin et al, 2019 ; Fauzy et al, 2019 ; Ugusman et al, 2020 ; Firdaus Azmi et al, 2021 ) and the remaining two studies were in vitro chemical assay studies ( Wongsa et al, 2012 ; Sallehuddin et al, 2020 ). For studies related to the effect of PS on hypertension, the animal models of hypertension used were spontaneous hypertensive rats (SHR) ( Mohd Zainudin et al, 2015 ; Fauzy et al, 2019 ; Mohd Zainudin et al, 2019 ), dexamethasone-induced hypertensive rats ( Ugusman et al, 2020 ; Firdaus Azmi et al, 2021 ) and N ω -nitro- l -arginine methyl ester hydrochloride ( l -NAME)-induced hypertensive rats ( Alwi et al, 2018 ). Meanwhile, induction of diabetes in all the studies were done through streptozotocin (STZ) injection.…”

Section: Resultsmentioning

confidence: 99%

Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis

et al. 2022

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Hypertension and diabetes mellitus are among the most prevalent diseases affecting people from all walks of life. Medicinal herbs have garnered interest as potential agents for the prevention and treatment of diabetes mellitus and hypertension due to their multiple beneficial effects. Piper sarmentosum Roxb. (PS) is an edible medicinal plant that has been traditionally used in Asia for treating hypertension and diabetes mellitus. This review is aimed to provide comprehensive information from the literature on the effects of PS on hypertension and diabetes mellitus. A computerized database search was performed on Scopus, PubMed and Web of Science databases with the following set of keywords: Piper sarmentosum AND diabetes mellitus OR diabetic OR diabetes OR hyperglyc*emia OR blood glucose OR HbA1c OR glycated h*emoglobin OR h*emoglobin A1c OR hyperten* OR blood pressure. A total of 47 articles were screened and 14 articles published between the years 1998 until 2021 were included for data extraction, comprising of six articles on antihypertensive and eight articles on antidiabetic effects of PS. These studies consist of two in vitro studies and eleven in vivo animal studies. Meta-analysis of three studies on hypertension showed that PS versus no treatment significantly lowered the systolic blood pressure with mean difference (MD) −39.84 mmHg (95% confidence interval (CI) −45.05, −34.62; p < 0.01), diastolic blood pressure with MD −26.68 mmHg (95% CI −31.48, −21.88; p < 0.01), and mean arterial pressure with MD −30.56 mmHg (95% CI −34.49, −26.63; p < 0.01). Most of the studies revealed positive effects of PS against hypertension and diabetes mellitus, suggesting the potential of PS as a natural source of antidiabetic and antihypertensive agents.

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“…For instance, AEPS up to 300 μg/ml concentration did not reduce endothelial cell viability (Sundar et al, 2019). In rats, treatment with 500 mg/kg/day AEPS for 28 days did not cause any remarkable change in blood pressure (Alwi et al, 2018;Ugusman et al, 2020;Azmi et al, 2021). Besides, rat aorta displayed normal histology under light and electron microscopic examinations following AEPS treatment (Thent et al, 2012a;Thent et al, 2012b).…”

Section: Discussionmentioning

confidence: 99%

Piper sarmentosum Roxb. Attenuates Vascular Endothelial Dysfunction in Nicotine-Induced Rats

et al. 2021

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Exposure to cigarette smoke is an important risk factor for cardiovascular diseases. Nicotine is an addictive compound in cigarette smoke that triggers oxidative stress, which leads to vascular dysfunction. Piper sarmentosum Roxb. is a herb with antioxidant and vascular protective effects. This study evaluated the potential protective effect of the aqueous extract of P. sarmentosum leaf (AEPS) on vascular dysfunction in rats induced with prolonged nicotine administration. A total of 22 male Sprague-Dawley rats were divided into control (normal saline, oral gavage [p.o.]), nicotine (0.8 mg/kg/day nicotine, intraperitoneally [i.p.]), and nicotine + AEPS groups (250 mg/kg/day AEPS, p.o. + 0.8 mg/kg/day nicotine, i.p.). Treatment was given for 21 days. Thoracic aortae were harvested from the rats for the measurement of vasorelaxation, vascular nitric oxide (NO) level, and antioxidant level and the assessment of vascular remodeling. Rats treated with AEPS had improved vasorelaxation to endothelium-dependent vasodilator, acetylcholine (ACh), compared with the nicotine-induced rats (p < 0.05). The presence of endothelium increased the maximum relaxation of aortic rings in response to ACh. Compared with the nicotine group, AEPS enhanced vascular NO level (p < 0.001) and increased antioxidant levels as measured by superoxide dismutase activity (p < 0.05), catalase activity (p < 0.01), and reduced glutathione level (p < 0.05). No remarkable changes in aortic histomorphometry were detected. In conclusion, P. sarmentosum attenuates vascular endothelial dysfunction in nicotine-induced rats by improving vasorelaxation and enhancing vascular NO and antioxidant levels.

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Piper sarmentosum attenuates dexamethasone-induced hypertension by stimulating endothelial nitric oxide synthase

Cited by 8 publications

References 20 publications

Effects of Piper sarmentosum on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence

Effects of Piper sarmentosum on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence

Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis

Piper sarmentosum Roxb. Attenuates Vascular Endothelial Dysfunction in Nicotine-Induced Rats

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