Effects of Piper sarmentosum on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence

Ekeuku, Sophia Ogechi; Azlina, Mohd Fahami Nur; Chin, Kok‐Yong

doi:10.3390/app11219860

Cited by 4 publications

(1 citation statement)

References 145 publications

(167 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, AEPS exhibits multiple cardiovascular protective effects, such as antidiabetic [ 19 ], antioxidant [ 25 ], anti-inflammatory [ 26 ], and anti-atherosclerotic effects [ 27 ]. The antihypertensive effect of AEPS has been validated in various hypertensive animal models, including spontaneously hypertensive rats [ 28 , 29 , 30 ], dexamethasone-induced hypertensive rats [ 31 , 32 ], and L-NAME-induced hypertensive rats [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Piper sarmentosum Roxb. Inhibits Angiotensin-Converting Enzyme Activity in Phorbol 12-Myristate-13-Acetate-Induced Endothelial Cells

Ugusman,

Ismail,

Nor Hisam

et al. 2024

IJMS

View full text Add to dashboard Cite

Angiotensin-converting enzyme (ACE) plays a crucial role in the pathogenesis of hypertension. Piper sarmentosum Roxb., an herb known for its antihypertensive effect, lacks a comprehensive understanding of the mechanism underlying its antihypertensive action. This study aimed to elucidate the antihypertensive mechanism of aqueous extract of P. sarmentosum leaves (AEPS) via its modulation of the ACE pathway in phorbol 12-myristate-13-acetate (PMA)-induced human umbilical vein endothelial cells (HUVECs). HUVECs were divided into five groups: control, treatment with 200 µg/mL AEPS, induction 200 nM PMA, concomitant treatment with 200 nM PMA and 200 µg/mL AEPS, and treatment with 200 nM PMA and 0.06 μM captopril. Subsequently, ACE mRNA expression, protein level and activity, angiotensin II (Ang II) levels, and angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R) mRNA expression in HUVECs were determined. AEPS successfully inhibited ACE mRNA expression, protein and activity, and angiotensin II levels in PMA-induced HUVECs. Additionally, AT1R expression was downregulated, whereas AT2R expression was upregulated. In conclusion, AEPS reduces the levels of ACE mRNA, protein and activity, Ang II, and AT1R expression in PMA-induced HUVECs. Thus, AEPS has the potential to be developed as an ACE inhibitor in the future.

show abstract

Section: Introductionmentioning

confidence: 99%

Piper sarmentosum Roxb. Inhibits Angiotensin-Converting Enzyme Activity in Phorbol 12-Myristate-13-Acetate-Induced Endothelial Cells

Ugusman,

Ismail,

Nor Hisam

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Effects of Piper sarmentosum on Bone Health and Fracture Healing: A Scoping Review

Ekeuku

Chin

Ramli

2023

EMIDDT

View full text Add to dashboard Cite

Background: Piper sarmentosum (PS) is a traditional herb used by Southeast Asian communities to treat various illnesses. Recent pharmacological studies have discovered that PS possesses antioxidant and anti-inflammatory activities. Since oxidative stress and inflammation are two important processes driving the pathogenesis of bone loss, PS may have potential therapeutic effects against osteoporosis. Objective: This review systematically summarised the therapeutic effects of PS on preventing osteoporosis and promoting fracture healing. Methods: A systematic literature search was performed in November 2021 using 4 electronic databases and the search string "Piper sarmentosum" AND (bone OR osteoporosis OR osteoblasts OR osteoclasts OR osteocytes). Results: Nine unique articles were identified from the literature. The efficacy of PS has been studied in animal models of osteoporosis induced by ovariectomy and glucocorticoids, as well as bone fracture models. PS prevented deterioration of bone histomorphometric indices, improved fracture healing and restored the biomechanical properties of healed bone in ovariectomised rats. PS also prevented osteoblast/osteocyte apoptosis, increased bone formation and mineralisation and subsequently improved trabecular bone microstructures and strength of rats with osteoporosis induced by glucocorticoids. Apart from its antioxidant and anti-inflammatory activity, PS also suppressed circulating and skeletal expression of corticosterone and skeletal expression of 11β hydroxysteroid dehydrogenase type 1 but increased 11β hydroxysteroid dehydrogenase type 1 enzyme activity in the glucocorticoid osteoporosis model. This review also identified several research gaps about the skeletal effects of PS and suggested future studies to bridge these gaps. Conclusion: PS may be of therapeutic benefit to bone health. However, further research is required to validate this claim.

show abstract

Natural products for managing metabolic syndrome: a scoping review

Abdulghani,

Al-Fayyadh

2024

Front. Pharmacol.

View full text Add to dashboard Cite

IntroductionMetabolic syndrome comprises a collection of metabolic disorders stemming from factors like genetic predisposition, inadequate nutrition, stress, decreased physical activity, aging, and ethnicity. Although traditional pharmaceutical treatments exist for metabolic syndrome, their limited popularity is attributed to high costs and adverse effects. Consequently, natural products with fewer side effects have been explored for managing this condition. This literature review aims to explore the role of natural products including herbs, botanicals, vitamins, minerals, probiotics, and dietary supplements in managing metabolic syndrome.MethodsThis scoping review was conducted in five steps, involving the formulation of a research question, the retrieval and extraction of relevant studies, the selection of pertinent studies, the organization of information into tables, and the reporting of results. Data was collected from various databases including Embase, Science Direct, PubMed, Google Scholar, Scopus, and Web of Science, with a focus on studies published from 2010 to the present, available in English and with full-text accessibility.ResultsWe identified 1,259 articles, screened their titles, abstracts, and full texts, ultimately incorporating 169 pertinent articles into this review (comprising 90 review articles, 32 trial articles, 6 in vitro articles, 38 in vivo articles, 1 experimental article and 2 observational articles). The study’s outcomes revealed that natural products, encompassing plants and their derivatives, vitamins and supplements, as well as probiotics, can exert a beneficial influence on metabolic syndrome by regulating blood sugar, blood pressure, lipid profiles, obesity, and abnormal cholesterol and triglyceride levels.ConclusionThe current study underscores the significance of natural products in addressing metabolic syndrome. Consequently, it is advisable to conduct further extensive research to assess the efficacy of these products, potentially integrating them into treatment regimens for individuals with metabolic syndrome.

show abstract

Effects of Piper sarmentosum on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence

Cited by 4 publications

References 145 publications

Piper sarmentosum Roxb. Inhibits Angiotensin-Converting Enzyme Activity in Phorbol 12-Myristate-13-Acetate-Induced Endothelial Cells

Piper sarmentosum Roxb. Inhibits Angiotensin-Converting Enzyme Activity in Phorbol 12-Myristate-13-Acetate-Induced Endothelial Cells

Effects of Piper sarmentosum on Bone Health and Fracture Healing: A Scoping Review

Natural products for managing metabolic syndrome: a scoping review

Contact Info

Product

Resources

About