2015
DOI: 10.5539/jas.v7n2p135
|View full text |Cite
|
Sign up to set email alerts
|

Piper nigrum Fruit Extract Prevents TMA-Induced Allergic Contact Dermatitis by Regulating Th2 Cytokine Production

Abstract: Allergic contact dermatitis (ACD) remains a leading skin disease in many countries. In this study, we investigated the preventive effect of Piper nigrum fruit extract (PFE) on trimellitic anhydride (TMA)-induced dermatitis and its potential mechanism of action. Oral administration of PFE and prednisolone (PS) significantly suppressed TMA-induced increases in ear, epidermal thickness, and infiltration of CD4 + cells, while abnormal expression of IgE, mMCP-1, IL-1β and IL-1β mRNA was also significantly counterac… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
2
1

Relationship

1
2

Authors

Journals

citations
Cited by 3 publications
(2 citation statements)
references
References 27 publications
0
2
0
Order By: Relevance
“…The symptoms of asthma or rhinitis were ameliorated by inhibiting the degranulation of mast cells, production of inflammatory cytokines, and Th2/Th17-associated immune responses. In a previous study, we found that the Piper nigrum fruit extract reduced TMA-induced allergic dermatitis symptoms via suppression of STAT6 phosphorylation in splenocytes and keratinocytes [55]. However, it was not known whether piperine could improve TMA-induced AD-like symptoms.…”
Section: Discussionmentioning
confidence: 96%
“…The symptoms of asthma or rhinitis were ameliorated by inhibiting the degranulation of mast cells, production of inflammatory cytokines, and Th2/Th17-associated immune responses. In a previous study, we found that the Piper nigrum fruit extract reduced TMA-induced allergic dermatitis symptoms via suppression of STAT6 phosphorylation in splenocytes and keratinocytes [55]. However, it was not known whether piperine could improve TMA-induced AD-like symptoms.…”
Section: Discussionmentioning
confidence: 96%
“…Interestingly, the immunomodulatory and anti-inflammatory potential of this alkaloid was explored by testing black pepper fruit extract in allergic contact dermatitis. The oral administration of piperine to mice showed an inhibitory effect upon eosinophils, IgE, and especially Th2 cytokine expression, which points to the potential of piperine in other inflammatory skin ailments [ 105 ]. In another work carried out by the same team, using a trimellitic anhydride (TMA)-induced AD-like mouse model, it was demonstrated that topical application of piperine resulted in the suppression of immune responses regulated by Th2 cytokines, noteworthily including the STAT6/GATA3/IL-4 signaling pathway [ 106 ].…”
Section: Isolated Natural Compounds Included In Nanotechnology-based ...mentioning
confidence: 99%