Pinta

Pardo-Castello, V.

doi:10.1001/archderm.1942.01500110003001

Cited by 18 publications

(7 citation statements)

References 4 publications

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“…Pardo-Costello and Ferrer (1942) reported on work done with the older nonspecific lipoidal tests. In the initial stages no serological reactivity was detected, in the intermediate stage 60 per cent.…”

Section: Discussionmentioning

confidence: 99%

“…of pinta patients showed CSF changes, namely increased globulin, syphilitic colloidal gold curves, and positive Meinicke reactions. Pardo-Costello and Ferrer (1942) reported that, when the spinal fluid of 23 patients with pinta was examined, twelve (52 per cent.) showed pathological changes similar to those encountered in cerebrospinal syphilis although there were no clinical manifestations.…”

Section: Discussionmentioning

confidence: 99%

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Treponemal IgG and IgM response in experimentally infected chimpanzees.

Duncan¹,

Kühn²

1974

Sexually Transmitted Infections

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Treponemal IgG and IgM response in experimentally infected chimpanzees.

Duncan¹,

Kühn²

1974

Sexually Transmitted Infections

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“…The other pathologic treponemal diseases (yaws and bejel) have population frequencies of bone involvement of 20%-40%, easily facilitating distinguishing these diseases from syphilis. Although pinta has been referred to as a separate disorder with pathology limited to the skin, review of the literature about pinta actually revealed the presence of bone involvement due to pinta to be no different from that due to the endemic treponeme found in the same area [70]. Infantile cortical hyperostosis (i.e., Caffey disease), thyroid acropachy, and hypertrophic osteoarthropathy do have significant nonfocal periosteal reactions, but these phenomena have low population frequencies and very characteristic patterns of periosteal reaction [25,71,72].…”

Section: Evidence-based Analysismentioning

confidence: 99%

History of Syphilis

Rothschild

2005

Clinical Infectious Diseases

132

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Evidence-based research now allows clear separation of syphilis from other diseases in its class of treponematoses. Examination of skeletons from populations with clinically diagnosed bejel and yaws revealed bone alterations distinctive to those diseases, clearly separating them from alterations due to syphilis, transcending the limitations of current DNA and immunologic technologies. These insights allowed confident identification of the New World origin of syphilis. Absence of skeletal evidence of any treponemal disease in continental Europe before the time of Columbus excludes it as site of origin of syphilis. Treponemal disease appears to have originated in East Africa with late transmission to England, perhaps as a complication of the slave trade. The original treponemal disease apparently spread from Africa through Asia, entering North America. Approximately 8 millennia later, it mutated to syphilis. Presence of skeletal evidence of syphilis at the site in the Dominican Republic where Columbus landed suggests the route by which it was transmitted to the Old World.

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“…Histologically, irregular epidermal hyperplasia with a sparse infiltrate of lymphocytes, plasma cells, and neutrophils around dilated vessels is characteristic of both the first and second stages, 193 with melanophages more prominent in the second stage. In the third stage, there is either marked hyperpigmentation with numerous melanophages or profound depigmentation with a scattered lymphocytic and plasma cellular infiltration.…”

Section: Tertiary Syphilismentioning

confidence: 99%