1974
DOI: 10.1136/sti.50.4.257
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Treponemal IgG and IgM response in experimentally infected chimpanzees.

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1976
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Cited by 4 publications
(2 citation statements)
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“…A possibly similar effect was seen by Duncan and Kuhn (1974) in experimentally infected chimpanzees where the production of anti-treponemal IgM antibodies ceased spontaneously in 10 out of 24 untreated animals.…”
Section: Discussionsupporting
confidence: 71%
“…A possibly similar effect was seen by Duncan and Kuhn (1974) in experimentally infected chimpanzees where the production of anti-treponemal IgM antibodies ceased spontaneously in 10 out of 24 untreated animals.…”
Section: Discussionsupporting
confidence: 71%
“…Recent studies have shown that VDRL reactivity develops in chimpanzees which are infected experimentally with either 7. pallidum or 7. cun;-CU//. 26 Fluorescent treponemal antibody (FTA), especially when present following absorption with 7. reiter (FTA-ABS), is highly specific for infection with 7. pallidum.-^' 2« Both IgG and IgM have been shown to participate.2' 2fi. so ^ jj interesting to note that rheumatoid arthritis and systemic lupus erythematosus, which also cause falsely positive VDRL results, are occasionally associated with a false-positive FTA-ABS.-" -' -' The reaction produced by serum from patients with lupus is said to be distinguishable microscopically from that due to syphilis;-^' it may result from leakage of nuclear material from the treponeme during processing.-'2 FTA-ABS are detectable in nearly all syphilitic patients, except those whose primary chancre is in its earliest stages.^''^ ^^ Once present, these antibodies probably persist for life, although one recent study"" suggests that this may not be the case.…”
Section: Intfrnational Journal Of Dermatolocy October 1976mentioning
confidence: 99%