Pingyangmycin sclerotherapy for infantile hemangiomas in oral and maxillofacial regions: an evaluation of 66 consecutive patients

Hou, Jinsong; Wang, M.; Tang, Huiping; Wang, Y.; Huang, Haidong

doi:10.1016/j.ijom.2011.07.906

Cited by 41 publications

(57 citation statements)

References 19 publications

(26 reference statements)

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“…2,3 The most common site is the lips, 4 but other areas, such as the tongue, buccal mucosa and palate have also been described. 3,5,6 Peak incidence is described soon after birth or in early infancy; but some cases have onset in adulthood. 2,3,6,7 Clinical definition is a fundamental part of diagnosis, because in cases of extensive involvement, surgery may cause difficult to control transoperative bleeding.…”

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confidence: 99%

“…3,5,6 Peak incidence is described soon after birth or in early infancy; but some cases have onset in adulthood. 2,3,6,7 Clinical definition is a fundamental part of diagnosis, because in cases of extensive involvement, surgery may cause difficult to control transoperative bleeding. Therefore, a combination of detection of medical signs on examination and supplementary test results can provide absolutely conclusive diagnoses in the majority of cases.…”

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confidence: 99%

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Treatment of oral hemangioma with sclerotherapy: case report

et al. 2014

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Hemangiomas are benign neoplasms that are common in the head and neck, but relatively rare in the oral cavity. They can cause esthetic and functional impairment, depending on location. The most common site is the upper lip, but they can occur in other areas, such as the tongue, buccal mucosa and palate. Treatment is primarily dependent on correct diagnosis of the lesion and on its anatomic location. The purpose of this article is to provide a description of a case of a hemangioma on the upper lip, treated by therapeutic sclerosis with monoethanolamine oleate (Ethamolin  ), covering clinical characteristics and methods for diagnosing these lesions. Precise diagnosis and appropriate therapeutic management resulted in satisfactory esthetic and functional results, with total regression of the lesion and no signs of relapse at 1-year follow-up.Keywords: hemangioma; sclerotherapy; neoplasms, vascular tissue; mouth; lip. ResumoO hemangioma é uma neoplasia benigna comum na região de cabeça e pescoço, e é relativamente rara na cavidade oral, podendo causar prejuízo estético e funcional a depender da sua localização. Sua localização mais frequente é o lábio superior, mas pode ocorrer em outras regiões, como língua, mucosa jugal e palato. O seu tratamento depende, principalmente, do correto diagnostico da lesão, bem como da localização anatômica da mesma. A proposta deste artigo é relatar um caso de hemangioma em lábio superior tratado com esclerose terapêutica com oleato de monoetanolamina (Ethamolin  ), considerando as características clínicas e os métodos de diagnóstico desta lesão. Por

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Treatment of oral hemangioma with sclerotherapy: case report

et al. 2014

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“…Bleomycin injection is generally safe, with reversible complications such as fever and vomiting. One patient (3%) suffered from skin ulceration, but in a larger series of 249 and 66 patients, no ulceration was reported (13,16). We report a high degree of success, with 96% of hemangiomas cured or substantially reduced.…”

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confidence: 60%

“…In another series, Hou et al achieved 88% cure or substantial reduction in 66 patients. It is possible our results are better than larger series due to our smaller patient cohort (13,16).…”

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confidence: 74%

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Ultrasound-guided Intralesional Bleomycin Injection (IBI) for Treatment of Cutaneous Hemangiomas and Vascular Malformations

Memon

Malik

Anjum

et al. 2016

JGR

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Purpose: To report the therapeutic outcome of ultrasound-guided intralesional injection of bleomycin in the treatment of cutaneous hemangiomas and vascular malformations. Material & Methods:The medical records of patients with cutaneous hemangiomas and vascular malformations treated with the intralesional injection of bleomycin under ultrasound guidance between August 2009 and June 2013 at the Indus Hospital, Karachi were reviewed retrospectively using a computerized medical record information management system. Data were extracted using a pre-coded performa that included patient demographics, type and location of lesion, number of treatments, presenting/pre-and post-treatment clinical symptoms (pain, swelling, heaviness, size, discoloration), ultrasound appearance and vascularity, and post-treatment side effects. The dose range of bleomycin was 0.5-1.0 mg/kg, but not exceeding 15 mg in a single session. A maximum of four treatments were given in any given patient except for one, who presented with recurrence after a year of complete resolution. Therapeutic outcome was determined using review of ultrasound images and recorded clinical assessment. Treatment response was categorized as: (i) complete resolution [more than 90% reduction]; (ii) substantial reduction [more than 50% reduction]; (iii) mild reduction [25% reduction]; or, (iv) no improvement [<10% reduction].Results: A total of 30 patients (16 female, 14 male), ranging in age from 8 months to 48 years (mean age 10.2 years), were treated from 2009 to 2013. There were 23 hemangiomas. Seven were vascular malformations, of which five were lymphatic malformations and two were venous malformations. Twenty-eight lesions were located in the head and neck region, and two were peripheral. In 24 of the 30 patients (76%), treatment had been completed. In six patients (21%) treatment was ongoing at the time of this report. Seventeen of the 23 hemangiomas (74%) were completely resolved clinically and on ultrasound, five (22%) showed substantial improvement and one (4%) showed mild improvement. In five of the seven vascular malformations (71%) lymphatic malformations resolved completely, and two (29%) venous malformations showed substantial improvement. Of the 13 patients presenting with discoloration, there was complete resolution in one (7.7%), marked reduction in 11 (84.6%) and mild reduction in one (7.7%). Of seven patients presenting with pain, there was complete resolution in two (28.6%), marked reduction in two (28.6%), mild reduction in two (28.6%), and no improvement in one (14.3%). There were no pulmonary complications. Conclusion:Ultrasound-guided intralesional injection of bleomycin is an option to consider for the treatment of certain types of cutaneous hemangiomas and vascular malformations. Prospective studies should be undertaken to understand the various factors contributing to therapeutic success. Ultrasound-guided Intralesional Bleomycin Injection (IBI) for Treatment of Cutaneous Hemangiomas and Vascular Malformations

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The changing face of complicated infantile hemangioma treatment

et al. 2016

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Infantile hemangiomas are the most common vascular tumors of infancy. A multidisciplinary approach including dermatologists, otolaryngologists, plastic surgeons, hematologists/oncologists and interventional/diagnostic radiologists is crucial for appropriate management of children with complicated infantile hemangiomas. Since its unforeseen discovery in 2008, propranolol has become the first-line treatment for infantile hemangiomas, eclipsing systemic corticosteroids and radiologic intervention. There are still, however, uncommon indications for more aggressive interventional management. We review the 2014-updated International Society for the Study of Vascular Anomalies (ISSVA) classification for vascular anomalies. Additionally, we suggest management algorithms for complicated lesions, including recommendations for radiologic and surgical intervention.

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Pingyangmycin sclerotherapy for infantile hemangiomas in oral and maxillofacial regions: an evaluation of 66 consecutive patients

Cited by 41 publications

References 19 publications

Treatment of oral hemangioma with sclerotherapy: case report

Treatment of oral hemangioma with sclerotherapy: case report

Ultrasound-guided Intralesional Bleomycin Injection (IBI) for Treatment of Cutaneous Hemangiomas and Vascular Malformations

The changing face of complicated infantile hemangioma treatment

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