Pineal region metastasis with intraventricular seeding

Ji, Junpeng; Li, Zhuoshi; Zhang, Mingshan; Zhang, Hongwei; Wang, Haoran; Qu, Yanming; Ming, Ren; Ning, Weihai; Yu, C. P.

doi:10.1097/md.0000000000016652

Cited by 10 publications

(16 citation statements)

References 33 publications

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“…[ 2 ] Meningiomas, schwannomas, and ependymoma are the most frequent tumors and others include chordomas and epidermoid cysts. [ 3 ] Metastatic neoplasms located in the foramen magnum are extremely uncommon, because brain metastases are the most commonly found at the junction of the hemispheric gray and white matter. It is reported in the literature that the tumors metastasized to the foramen magnum can come from prostate adenocarcinoma and malignant melanoma, but the tumors from NE cancer have not been reported.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic large cell neuroendocrine lung cancer to the foramen magnum

Zou

Liu²,

Cheng³

et al. 2020

Medicine

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Rationable: Large cell neuroendocrine carcinoma of the lung is rare, especially in the area of the foramen magnum. No previous studies have reported metastatic large cell neuroendocrine lung cancer to the foramen magnum. This paper will be the first time to report this special case. Patient concerns: A case of a 37-year-old woman presented with headache that had developed 20 days previously. Imaging examination revealed a circular abnormal signal at the posterior margin of the foramen magnum. Diagnoses: The patient we report was diagnosed with a metastatic intracranial tumor. Interventions: The patient underwent occipital craniotomy. Pathological results showed metastatic neuroendocrine carcinoma of the brain. Whole body PET-CT examination showed that fusiform soft tissue shadows could be seen near the hilum of the lower lobe of the left lung. Outcomes: The final bronchoscopy pathological results showed the large cell neuroendocrine carcinoma of the lung. The patient underwent further chemotherapy and radiotherapy in the oncology department. Lessons: Diagnosis and treatment of large cell neuroendocrine carcinoma of the lung are difficult. The prognosis is poorer, and effective treatment is urgently needed.

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Section: Discussionmentioning

confidence: 99%

“…However, metastatic neoplasms located in the foramen magnum are extremely uncommon. [ 3 ] Brain metastases are the most commonly found at the junction of the hemispheric gray and white matter. To the best of our knowledge, no studies have reported metastatic large cell NE lung cancer to the foramen magnum.…”

Section: Introductionmentioning

confidence: 99%

Metastatic large cell neuroendocrine lung cancer to the foramen magnum

Zou

Liu²,

Cheng³

et al. 2020

Medicine

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“…The pineal gland, or epiphysis cerebri, represents an exceptionally uncommon site of systemic metastasis (1, 2). Indeed, metastasis to the pineal gland is most commonly a derivative of a primary lung malignancy; however, numerous other primary malignancies have been reported to metastasize to the epiphysis cerebri including esophageal, stomach, liver, colon, pancreas, kidney, bladder, prostate, thyroid, breast, melanoma, myeloma, and leukemia (3,4). Considered one of the neuroendocrine secretory circumventricular organs, capillaries of the pineal gland are mostly permeable to solutes in the blood (8).…”

Section: Discussionmentioning

confidence: 99%

“…Although metastasis to the brain is common in the setting of primary malignancies, metastasis specifically to the pineal region is an exceedingly rare phenomenon accounting for 0.4-3.8% of all intracranial metastases (1,2). Metastasis to the pineal gland is most commonly a derivative of a primary lung malignancy; nevertheless, there are reports of a variety of primary tumors that have metastasized to this neuroendocrine secretory circumventricular organ including esophageal, stomach, liver, colon, pancreas, kidney, bladder, prostate, thyroid, breast, melanoma, myeloma, and leukemia (3,4). However, to the best of the authors' knowledge, pineal gland metastasis without a primary origin has yet to be described.…”

Section: Introductionmentioning

confidence: 99%

Pineal Gland Metastasis From Poorly Differentiated Carcinoma of Unknown Primary Origin

et al. 2020

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Pineal metastasis is an exceedingly rare finding in patients with systemic malignancies. Such lesions are typically the manifestation of a primary lung cancer; nonetheless, a variety of malignancies have been reported to disseminate to the pineal gland including gastrointestinal, endocrine, and skin cancers, among others. However, to our knowledge, pineal gland metastasis without a primary origin has yet to be described. Carcinoma of unknown primary origin is a heterogeneous group of cancers characterized by the presence of metastatic disease without an identifiable primary tumor on metastatic workup. Here, we present a case of a 65-year-old male found to have a heterogeneously enhancing lesion of the pineal gland as well as an enhancing lesion of the left cerebellar hemisphere. Comprehensive metastatic workup demonstrated multifocal metastatic adenopathy without an identifiable primary lesion. Stereotactic biopsy of the pineal lesion revealed poorly differentiated carcinoma with an immunophenotype most consistent with gastrointestinal origin. To our knowledge, this is the first case to describe a pineal gland metastasis without a primary origin. We discuss the relevant literature on pineal gland metastases as well as carcinoma of unknown primary origin.

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“…Metastatic cancer spreading to the pineal gland is exceedingly uncommon and originates from lung carcinoma in most cases ( Figure 10 ). Other tumors that have documented cases of metastases to the pineal gland are pancreatic, esophageal and bladder neoplasms [ 110 , 111 , 112 , 113 ].…”

Section: A Brief Overview Of Other Neoplastic and Non-neoplastic Pmentioning

confidence: 99%

Pineal Gland Tumors: A Review

Favero

Bonomini

Rezzani

2021

Cancers

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The pineal gland is a small, pinecone-shaped endocrine gland that participates in the biological rhythm regulation of vertebrates. The recognized major product of the pineal gland is melatonin—a multifunctional endogenous indoleamine. Accumulating evidence suggests that the pineal gland is important for preserving ideal health conditions in vertebrate. Tumors of the pineal region account for approximately 3–11% of pediatric brain neoplasms but fewer than 1% of brain neoplasms in adults. It is fundamental to expand advanced imaging techniques together with both clinical and laboratory knowledge, to help to differentiate among pineal neoplasms and thus facilitate accurate primary diagnoses and proper therapeutic interventions. In this review, we report the gross anatomy of the pineal gland and its functional significance and discuss the clinical relevance of pineal gland tumors, underlining the importance of identifying the leading causes of pineal region masses.

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Pineal region metastasis with intraventricular seeding

Cited by 10 publications

References 33 publications

Metastatic large cell neuroendocrine lung cancer to the foramen magnum

Metastatic large cell neuroendocrine lung cancer to the foramen magnum

Pineal Gland Metastasis From Poorly Differentiated Carcinoma of Unknown Primary Origin

Pineal Gland Tumors: A Review

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