Pineal melatonin secretion, but not ocular melatonin secretion, is sufficient to maintain normal immune responses in Japanese quail (Coturnix coturnix japonica)

Moore, CB; Siopes, T. D.; Steele, Christopher T.; Underwood, Herbert

doi:10.1016/s0016-6480(02)00011-4

Cited by 24 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…В последние годы значительное внимание уделяется взаимодействию между пинеальной железой и иммунной системой (Guerrero, Reiter, 2002;Maestroni, 2001;Srinivasan et al, 2005;Moore et al, 2002). Особенно существенна роль мелатонина как иммуномодулятора при нарушениях иммунологического статуса, вызванных снижением эндогенного уровня гормона при функциональных и фармакологических воздействиях (Srinivasan et al, 2005;Moore et al, 2002). Уровень мелатонина положительно коррелирует как с гуморальным (Akbulut et al, 2001), так и с клеточным иммунитетом (Brennan et al, 2002;Champney et al, 1997).…”

Section: Discussionunclassified

Effect constant and natural illumination on physiological state in rats

Ilyukha¹,

Виноградова²,

Khizhkin³

et al. 2012

Principles of the Ecology

View full text Add to dashboard Cite

Section: Discussionunclassified

Effect constant and natural illumination on physiological state in rats

Ilyukha¹,

Виноградова²,

Khizhkin³

et al. 2012

Principles of the Ecology

View full text Add to dashboard Cite

“…Peripheral blood lymphocytes were cultured using routine cytogenetics protocol (Moore et al, 2002). Chromosomes were stained by G banding, according to Seabright (1971).…”

Section: Cytogenetic Analysismentioning

confidence: 99%

Next-Generation Sequencing Reveals Novel Mutations in X-linked Intellectual Disability

Muthusamy

Selvan²,

Nguyen³

et al. 2017

OMICS: A Journal of Integrative Biology

View full text Add to dashboard Cite

Robust diagnostics for many human genetic disorders are much needed in the pursuit of global personalized medicine. Next-generation sequencing now offers new promise for biomarker and diagnostic discovery, in developed as well as resource-limited countries. In this broader global health context, X-linked intellectual disability (XLID) is an inherited genetic disorder that is associated with a range of phenotypes impacting societies in both developed and developing countries. Although intellectual disability arises due to diverse causes, a substantial proportion is caused by genomic alterations. Studies have identified causal XLID genomic alterations in more than 100 protein-coding genes located on the X-chromosome. However, the causes for a substantial number of intellectual disability and associated phenotypes still remain unknown. Identification of causative genes and novel mutations will help in early diagnosis as well as genetic counseling of families. Advent of next-generation sequencing methods has accelerated the discovery of new genes involved in mental health disorders. In this study, we analyzed the exomes of three families from India with nonsyndromic XLID comprising seven affected individuals. The affected individuals had varying degrees of intellectual disability, microcephaly, and delayed motor and language milestones. We identified potential causal variants in three XLID genes, including PAK3 (V294M), CASK (complex structural variant), and MECP2 (P354T). Our findings reported in this study extend the spectrum of mutations and phenotypes associated with XLID, and calls for further studies of intellectual disability and mental health disorders with use of next-generation sequencing technologies.

show abstract

“…In this respect, Brainard et al79 showed a lack of evident germinal centers and an apparent inactivity of the red pulp in the Syrian hamster spleen, while Jankovic et al84 found a delayed development not only in the bursa but also in the thymus and spleen of pinealectomized chicks. The absence of the pineal gland has also been reported to significantly reduce IL-2 production and NK activity85,86 and decrease the cellular and humoral immune response of both mammals and birds 87–90. When melatonin is administered to pinealectomized animals, the effects on immune system are typically reversed.…”

Section: Tryptophan Serotonin Melatonin and The Immune Systemmentioning

confidence: 99%

Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function:Streptopelia Risoriaas a Model

Paredes

Barriga

Reíter

et al. 2009

Int J�Tryptophan�Res

View full text Add to dashboard Cite

Abstract:In the present review we summarize the relationship between the amino acid, tryptophan, the neurotransmitter, serotonin, and the indole, melatonin, with the rhythms of sleep/wake and the immune response along with the possible connections between the alterations in these rhythms due to aging and the so-called "serotonin and melatonin defi ciency state." The decrease associated with aging of the brain and circulating levels of serotonin and melatonin seemingly contributes to the alterations of both the sleep/wake cycle and the immune response that typically accompany old age. The supplemental administration of tryptophan, e.g. the inclusion of tryptophan-enriched food in the diet, might help to remediate these agerelated alterations due to its capacity of raise the serotonin and melatonin levels in the brain and blood. Herein, we also summarize a set of studies related to the potential role that tryptophan, and its derived product melatonin, may play in the restoration of the aged circadian rhythms of sleep/wake and immune response, taking the ringdove (Streptopelia risoria) as a suitable model.

show abstract

Pineal melatonin secretion, but not ocular melatonin secretion, is sufficient to maintain normal immune responses in Japanese quail (Coturnix coturnix japonica)

Cited by 24 publications

References 30 publications

Effect constant and natural illumination on physiological state in rats

Effect constant and natural illumination on physiological state in rats

Next-Generation Sequencing Reveals Novel Mutations in X-linked Intellectual Disability

Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function:Streptopelia Risoriaas a Model

Contact Info

Product

Resources

About