Pilot Study to Evaluate the Adjunct Use of a Povidone-Iodine Topical Antiseptic in Patients with Soft Tissue Abscesses

Olson, Adriana Segura; Rosenblatt, Lauren; Salerno, N.; Odette, Julie; Ren, Ronnie; Emanuel, Tatiana; Michalek, Joel E.; Liu, Qianqian; Du, Liem C.; Jahangir, Kourosh; Schmitz, Gillian

doi:10.1016/j.jemermed.2018.12.026

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…In studies of povidone‐iodine the results are mixed. In a study comparing the effect of clinical cure rates in patients with soft tissue abscesses, the authors found no differences in the treatment of incising, draining and irrigating, either alone or with the addition of povidone‐iodine 37 . In another study only 2% fusidic acid but not 10% povidone‐iodine showed significant reduction ( P < .01) in colony counts of S. aureus from biofilm in the croton oil dermatitis mice compared to untreated mice 38 .…”

Section: Discussionmentioning

confidence: 98%

Lugol's solution and Gentian violet eradicate methicillin‐resistant Staphylococcus aureus biofilm in skin wound infections

Grønseth

Ovchinnikov

Carlsen

et al. 2022

International Wound Journal

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The study aimed to evaluate the antibacterial efficacy of Lugol's solution 5% and Gentian violet 1% against methicillin‐resistant Staphylococcus aureus (MRSA) biofilm in vivo. The bactericidal efficacy for treatment of MRSA‐biofilm skin wound infection was tested in a murine model. Luciferase‐tagged S. aureus Xen31, a MRSA‐strain derived from S. aureus ATCC‐3359130, was used for infection. Wounds were made in the skin of mice and infected with MRSA. The mice were treated with Lugol's solution and Gentian violet. Application of the antimicrobial agents started 24 hours post infection and was repeated daily for five‐days. The antimicrobial effect on the biofilm bacteria was evaluated by measuring bioluminescence from MRSA daily for seven‐days. Lugol's solution and Gentian violet showed a significant reduction in luminescent signals from the first assessment day to all subsequent days (P < .001). Lugol's solution and Gentian violet effectively eradicated MRSA in biofilm in vivo and could be alternatives or in addition to topical antibiotics when MRSA‐biofilm wound infection is suspected.

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Section: Discussionmentioning

confidence: 98%

Lugol's solution and Gentian violet eradicate methicillin‐resistant Staphylococcus aureus biofilm in skin wound infections

Grønseth

Ovchinnikov

Carlsen

et al. 2022

International Wound Journal

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“…MRSA was primary introduced in 1961 and has been documented as a serious health issue due to the difficulty of controlling these strains 17 . The reoccurrence of the MRSA problem appears to be due to a deficiency of strong therapeutic drugs that have effect of cell-killing and can eliminate it from the patient's body 18 . Hospitals and society face the problem of controlling and eradicating this resistant organism as these infections are linked with longer hospital stays, increased mortality and high hospitalization charges compared to patients with methicillin-sensitive Staphylococcus aureus.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Methicillin Resistant Staphylococcus Aureus (MRSA) Among Patients Necessitating Reconstructive Surgery

Atiq¹,

Tehreem²,

Murtaza³

et al. 2022

PJMHS

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Purpose: Staphylococcus aureus is an important nosocomial pathogen and the progression of methicillin resistance stances a most important threat for its control. The current study was directed to govern the MRSA prevalence and its susceptibility to various antibiotics given for anti-staphylococcal strains in OPD treated patients. Study design: Prospective descriptive study. Place and duration: This study was conducted in the East Surgical Ward of Mayo Hospital, Lahore for two-year duration from January 2020 to December 2021. Methods: A total of 200 patients with septic wounds of both sexes were encompassed in the study. Swabs were taken from wounds which were infected and Stuart's medium was used to transport them. The samples were grown onto MacConkey agar, nutrient agar and blood agar and for 24 hours; incubated at 37 ° C. All MRSA isolates were biochemically and morphologically identified using standard procedures of laboratory by processing clinical specimens submitted to a microbiology laboratory. All isolates were tested for patterns of resistance and sensitivity. Results: A total of 200 patients were included, 115 (57.5%) were men and 85 (42.5%) were women with 27.3 years of mean age and age range from 15-70 years. The incidence of positive cases confirmed by culture was 118 (59%) and the MRSA incidence was 78 (39%). Of the 78 cases of MRSA, 50 (64.10%) are men and 28 (35.90%) are women. The incidence of other microorganisms was 40 (33.8%). MRSA was 100% sensitive to vancomycin, teicoplanin and linezolid. Of these, 24.4% were sensitive to cotrimoxazole, 47.4% were sensitive to fucidic acid and 28.2% were sensitive tetracycline antibiotics. Cultured MRSAs were resistant 100% to main antibiotic groups including penicillin, macrolides, cephalosporins, fluoroquinolones, meropenem, imipenem, gentamicin, and tazobactum/ pipracillin. Of all 78 MRSA patients, > 50% were from general surgery and orthopaedics departments, and the remainder from other related specialties, such as Gynecology, pediatric surgery, maxillofacial surgery, neurosurgery and otolaryngology. Of 78 patients with MRSA, 70 (89.7%) were hospitalized with a history of hospitalization, and 60 (76.9%) were hospitalized for >1-week. The organism was institute to be hundred percent resistant to the generally directed antibiotics. Conclusions: The incidence of MRSA is increasing. The organism spreads readily in a hospital setting, causing morbidity, mortality and higher costs. Special infection control actions and precautions should be taken to stop and prevent the MRSA spreading. Keywords: Nosocomial infections, MRSA and Antibiotic resistance

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Iodine Impregnated Poly(N-Vinylpyrrolidone) Grafted Antibacterial Cotton Gauze for Wound Dressing Applications

2020

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Pilot Study to Evaluate the Adjunct Use of a Povidone-Iodine Topical Antiseptic in Patients with Soft Tissue Abscesses

Cited by 6 publications

References 17 publications

Lugol's solution and Gentian violet eradicate methicillin‐resistant Staphylococcus aureus biofilm in skin wound infections

Lugol's solution and Gentian violet eradicate methicillin‐resistant Staphylococcus aureus biofilm in skin wound infections

Incidence of Methicillin Resistant Staphylococcus Aureus (MRSA) Among Patients Necessitating Reconstructive Surgery

Iodine Impregnated Poly(N-Vinylpyrrolidone) Grafted Antibacterial Cotton Gauze for Wound Dressing Applications

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