Iodine Impregnated Poly(N-Vinylpyrrolidone) Grafted Antibacterial Cotton Gauze for Wound Dressing Applications

Rashmi, Rashmi; Pahwa, Rimpy; Ahuja, Munish

doi:10.1007/s12221-020-9856-1

Cited by 9 publications

(5 citation statements)

References 19 publications

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“…[ 16–19 ] Except in a study published in the literature, the authors claimed that they reached more than 200% grafting yield of NVP onto the cotton fabric when they utilized microwave‐assisted graft copolymerization using ammonium persulfate (APS) as an oxidant. [ 20 ] In the study, the amount of NVP was reported to be more than 5 mL, possibly leading to bulk poly( N ‐vinylpyrrolidone) (PVP or PNVP) formation. However, the post‐cleaning procedure for adhered PVP homopolymer removal was done with distilled water at room temperature, which seems incapable of removing adhered PVP polymers onto the fabric surface.…”

Section: Introductionmentioning

confidence: 99%

Design of Silk Fabric Surface with Enhanced Antiseptic Properties through Graft Modification and Iodophor Integration

Dinçer,

Erdoğan,

OmerOglou

et al. 2024

Macro Chemistry & Physics

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To improve the hydrophobic character of silk and impart iodine complex ion adsorption, the surface of woven silk fabric is enriched by different functional groups through the grafting of N‐vinylpyrrolidone (NVP), ethylene glycol dimethacrylate (EGDMA), and their mixtures (NVP–EGDMA). The dominant fibrous texture of silk enables an efficient graft copolymerization in terms of high grafting yield (>30%) after applying a mild degumming process. The structural and morphological alterations in the silk surface are evidenced with attenuated total reflectance‐fourier transform infrared spectroscopy (ATR‐FTIR), X‐ray diffraction (XRD), and scanning electron microscopy (SEM) techniques. The imparted hydrophilicity property of the samples is revealed by contact angle–wetting time measurements. The usability of the graft‐modified samples as an iodophor polymeric substrate is then examined by treatment with I2/KI solutions, and the results are monitored using UV–vis spectroscopy. It is obtained that the NVP–EGDMA mixture‐grafted sample exhibits satisfactorily high iodine adsorption compared to untreated and NVP‐grafted silk samples, such as 0.05 g per 1 g fabric with high antibacterial activity against various pathogens, including methicillin‐resistant Staphylococcus aureus (MRSA) responsible for hospital‐acquired infections. This finding evidences its potential as an alternative antiseptic tissue for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Design of Silk Fabric Surface with Enhanced Antiseptic Properties through Graft Modification and Iodophor Integration

Dinçer,

Erdoğan,

OmerOglou

et al. 2024

Macro Chemistry & Physics

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“…demonstrated that cotton gauze impregnated with N-vinyl pyrrolidone/iodine exhibited excellent antibacterial properties, blood absorbency, and clotting abilities, making them highly functional for wound dressing (Rashmi et al 2020). There is a growing interest in modifying cotton gauzes with hydrogels to optimize their properties for potential use as dressings for skin wounds.…”

Section: Introductionmentioning

confidence: 99%

Poly(N-vinyl caprolactam-co-maleic anhydride)-grafted cotton gauze with antimicrobial properties for their potential use as wound dressings

Carrillo-Rodríguez,

Betancourt-Galindo,

Meléndez-Ortiz

et al. 2023

Preprint

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Medical cotton gauzes were modified by grafting poly(N-vinylcaprolactam-co-maleic anhydride) (gauze-g-(PVCL-co-MA)) through free radical polymerization to prepare a novel wound dressing with antimicrobial and drug delivery capabilities. Several gauze-g-(PVCL-co-MA) were synthesized, each with distinct grafting percentages. For characterization, the selected percentages were 23, 40, and 100%, designated as VMG1, VMG2, and VMG3, respectively. Polymer grafting was verified using methods such as Fourier Transform Infrared Spectroscopy (FT-IR), Thermogravimetric analysis (TGA), Scanning Electronic Microscopy (SEM), and swelling studies. The grafted cotton gauzes were loaded with vancomycin and tested as drug-eluting systems, exhibited considerable loading capacity and over 80% release. The antibacterial activity was evaluated against S. aureus (ATCC 29213) according to the Japanese Industrial Standard JIS Z 2801 method. They showed growth inhibition for this microorganism. Moreover, they showed good biocompatibility for the 1132SK and SaOS-2 cell lines. These results suggest that the gauze-g-(PVCL-co-MA) could be used as antimicrobial and drug-eluting wound dressings in the biomedical field.

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“…Such pathological situations expedite an urgent demand for wound dressings loaded with antimicrobial agents 3,4 . These anti‐infective wound dressings can prevent bacterial penetration into the wound and avoid the growth of microorganisms by incorporating agents include antibiotics, 5,6 slivers, 7,8 iodine, 9,10 chlorhexidine, 11 and so forth, among which antibiotics‐loaded have accounted for nearly half of commercial wound dressings.…”

Section: Introductionmentioning

confidence: 99%

Nanofibrous dressing: Potential alternative for fighting against antibiotic‐resistance wound infections

Yingjie

Zhang

et al. 2022

J of Applied Polymer Sci

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The progression of antibiotic‐resistant bacteria (ARB) as well as impaired immunity due to chronic diseases and complications, aging, and so forth pose opportunities in parallel with challenges to the wound dressing products. In a bid to address the remedies, electrospun nanofibrous membranes (ENMs) with high permeability and good biocompatibility have made an entry as wound dressings. With high specific surface area, such ENMs can pave the way for the loading and release of antimicrobial agents and further promote wound healing by mimicking the extracellular matrix structure. In this review, we have compiled a series of novel antimicrobial agents that can be substituted for antibiotics against ARB and outlined their antimicrobial mechanisms, providing an overview of the latest research to illustrate how ENMs can achieve the loading and efficient release of antimicrobial agents against ARB. Last but not least, on the basis of the demands for timely and accurate wound diagnosis, ENMs capable of colorimetric detection are featured as test‐strips for the diagnosis of wound pathogenic bacteria, in the hope of inspiring researchers to design smart wound dressings capable of diagnosis and treatment integration.

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Iodine Impregnated Poly(N-Vinylpyrrolidone) Grafted Antibacterial Cotton Gauze for Wound Dressing Applications

Cited by 9 publications

References 19 publications

Design of Silk Fabric Surface with Enhanced Antiseptic Properties through Graft Modification and Iodophor Integration

Design of Silk Fabric Surface with Enhanced Antiseptic Properties through Graft Modification and Iodophor Integration

Poly(N-vinyl caprolactam-co-maleic anhydride)-grafted cotton gauze with antimicrobial properties for their potential use as wound dressings

Nanofibrous dressing: Potential alternative for fighting against antibiotic‐resistance wound infections

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