Pilot Study of the Metabolomic Profile of an Athlete after Short-Term Physical Activity

Malsagova, Kristina A.; Kopylov, Arthur T.; Pustovoyt, Vasiliy I.; Stepanov, Alexander A.; Enikeev, Dmitry; Potoldykova, Natalia V.; Balakin, Evgenii I.; Kaysheva, Anna L.

doi:10.3390/data8010003

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…Data acquisition was performed using a high-resolution quadrupole time-of-flight (Q-TOF) Xevo G2-XS mass spectrometer (Waters, Inc., Ireland, Milford) equipped with a Z-spray ionization source coupled with a UPLC Acquity H Class (Waters, Inc., Ireland, Milford) system. Details of instrumental analysis are available in [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

Molecular Profiling of Athletes Performing High-Intensity Exercises in Extreme Environments

Malsagova

Kopylov

Stepanov

et al. 2023

Sports

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The aim of this study was to determine the influence of high-intensity training under extreme conditions (T = 40 °C) on the metabolism and immunological reactions of athletes. Male triathletes (n = 11) with a high level of sports training performed load testing to failure (17 ± 2.7 min) and maximum oxygen consumption (64.1 ± 6.4 mL/min/kg). Blood plasma samples were collected before and immediately after exercise. Mass spectrometric metabolomic analysis identified 30 metabolites and 6 hormones in the plasma, of which 21 and 4 changed after exercise, respectively. Changes in the intermediate products of tricarboxylic and amino acids were observed (FC > 1.5) after exercise. The obtained data can be associated with the effect of physical activity on metabolism in athletes. Therefore, constant monitoring of the biochemical parameters of athletes can help coaches identify individual shortcomings in a timely manner and track changes, especially as the volume of training increases. In addition, it was revealed that the immunological reaction (manifestation of a hyperactive reaction to food components) is personalized in nature. Therefore, it is important for coaches and sports doctors to analyze and control the eating behavior of athletes to identify food intolerances or food allergies in a timely manner and develop an individual elimination diet.

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Section: Methodsmentioning

confidence: 99%

Molecular Profiling of Athletes Performing High-Intensity Exercises in Extreme Environments

Malsagova

Kopylov

Stepanov

et al. 2023

Sports

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“…Боль в медиальной подошвенной части пяточной ко сти ухудшает качество жизни миллионов людей во всем мире. Подсчитано, что 7 % людей старше 65 лет предъ являют жалобы на боль такого рода [1][2][3]. Одной из при чин такой боли является плантарный фасциит (ПФ)заболевание, приводящее к выраженному нарушению качества жизни, его возникновение обусловлено дегене ративновоспалительными процессами в области подо швенной фасции [4][5][6][7].…”

Section: Introductionunclassified

Clinical and radiological characteristics of patients with plantar fasciitis

Anischenko,

Dzhadayev,

Dzhadayeva

et al. 2023

jour

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Aim: to study the clinical and radiological parameters of patients with plantar fasciitis.Materials and methods: the study involved 91 patients with plantar fasciitis, 73 (80.2%) women, 18 (19.8%) men. The mean age of the patients was 53.42 ± 9.16 years, disease duration was 30.32 ± 8.06 days, BMI was 24.75 ± 4.55 kg/m2. Patients underwent history taking, pain level and quality of life were assessed using the visual analogue scale, the SF-36 questionnaire and the AOFAS scale. The functional state of the feet was assessed using plantoscopy, Y-balance test, Friedland index. X-ray parameters were assessed using magnetic resonance imaging.Results: the disease is common among women aged 51 to 60 years. In 100% of cases, there is no traumatic etiological factor, 42.9% of the subjects note an increase in body weight as the cause, 35.2% – the relationship of the onset of pain with wearing flat shoes; men are more likely to associate the onset of symptoms with an increase in physical activity (83.3%). Subjective sensation of pain on the VAS does not depend on gender (p = 0.280), age (p = 0.509), disease duration (p = 0.371), BMI (p = 0.974). X-ray parameters of patients are characterized in 49.5% by the absence of heel exostosis, in other cases, the development of a heel spur is more typical for women (p = 0.019), its length does not depend on the duration of the disease (p = 0.845), age (p = 0.054), BMI (p = 0.196), lifestyle (p = 0.324) and does not correlate with the severity of pain (p = 0.691). The level of pain is directly proportional to the thickness of the plantar fascia (p < 0.001, ρ = 0.459). Calcaneal edema is observed in 14.3 % of patients, soft tissue edema — in 18.7 %; there was no relationship between calcaneal edema (p = 0.604) and soft tissue edema (p = 0.541) with the severity of pain, and calcaneal edema directly correlates with BMI (p = 0.029).Conclusion: These studies suggest that among the predictors of the development of plantar fasciitis, the most significant are female gender, overweight, wearing flat shoes, and the disease itself is not always a consequence of the development of a heel spur.

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Mexidol, Cytoflavin, and succinic acid derivatives as antihypoxic, anti‐ischemic metabolic modulators, and ergogenic aids in athletes and consideration of their potential as performance enhancing drugs

Jędrejko,

Catlin,

Stewart

et al. 2024

Drug Testing and Analysis

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Emoxypine (ethylmethylhydroxypyridine) is a synthetic derivative of vitamin B6. Emoxypine succinate is a registered drug in Russia and Ukraine under various trade names including Mexidol, Mexicor, and Armadin Long. Mexidol demonstrates antihypoxic and anti‐ischemic effects and also modulates metabolism. The use of Mexidol by Russian athletes has been confirmed in the past. Current use by athletes is unknown as this drug is not monitored or included in drug testing protocol. Metabotropic and antihypoxic effects of Mexidol were compared to the effects of meldonium or trimetazidine, both of which are included on the World Anti‐Doping Agency (WADA) Prohibited List in category S4.4. Metabolic Modulators. The conjugation of emoxypine with succinate elevates the therapeutic effectiveness of the Mexidol formulation as succinic acid itself has important impacts to consider despite being a common food additive and drug excipient. Other succinic acid salts like ammonium succinate, found as dietary supplement, have been patented as performance enhancers. Available research on healthy subjects suggests that combinations of selected 3‐substituted pyridine derivatives with succinate including Mexidol and a related drug Cytoflavin can enhance the performance of athletes. Cytoflavin is a multi‐component formula containing meglumine sodium succinate, nicotinamide (vitamin B3), inosine (riboxin), and riboflavin. Other related succinate‐based drugs include Remaxol, Reamberin, and Cogitum. Mexidol and Cytoflavin and related substances exhibit similar biological effects as drugs on the WADA Prohibited List, and if they are used for performance enhancement by athletes, they could be worthy of consideration as prohibited substances in sport.

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Pilot Study of the Metabolomic Profile of an Athlete after Short-Term Physical Activity

Cited by 3 publications

References 35 publications

Molecular Profiling of Athletes Performing High-Intensity Exercises in Extreme Environments

Molecular Profiling of Athletes Performing High-Intensity Exercises in Extreme Environments

Clinical and radiological characteristics of patients with plantar fasciitis

Mexidol, Cytoflavin, and succinic acid derivatives as antihypoxic, anti‐ischemic metabolic modulators, and ergogenic aids in athletes and consideration of their potential as performance enhancing drugs

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