Pilot Study of Prostate Cancer Angiogenesis Imaging Using a Photoacoustic Imaging System

Horiguchi, Akio; Shinchi, Masayuki; Nakamura, Akiko; Wada, Takahito; Ito, Keiichi; Asano, Tomohiko; Shinmoto, Hiroshi; Tsuda, Hitoshi; Ishihara, Miya

doi:10.1016/j.urology.2017.07.008

Cited by 60 publications

(58 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Photoacoustic imaging (PAI) is currently in the progress of translation as a viable clinical deep tissue imaging modality for the detection of breast, [ 1 ] prostate, [ 2 ] melanoma, [ 3 ] cervical and ovarian cancers, [ 4 ] as well as sentinel lymph nodes. [ 3,5 ] In addition, PA imaging has been evaluated for the characterization of inflammatory bowel disease, [ 6 ] metabolism of brown fat, [ 7 ] Duchenne muscular dystrophy disease, [ 8 ] and the depth analysis of periodontal pockets.…”

Section: Figurementioning

confidence: 99%

Tuning Optical Properties of BODIPY Dyes by Pyrrole Conjugation for Photoacoustic Imaging

Merkes

Lammers

Kancherla

et al. 2020

Advanced Optical Materials

View full text Add to dashboard Cite

Photoacoustic imaging (PAI) is increasingly employed in (pre‐) clinical research, thus, development of suitable contrast agents, in particular fluorescence‐quenched chromophores, for PAI is of high importance. Small molecule dyes are appropriate due to favorable circulation, excretion properties, and ease of conjugation to targeting moieties. The BODIPY chromophores have been widely used in bioimaging, yet they are not ideal for PAI due to high fluorescence. Hence, here nonfluorescent BODIPY are designed by 1H‐pyrrole conjugation (PyBODIPY) to apply as probes for PAI. The PyBODIPYs exhibit absorption maxima up to 800 nm, and PA signal could be detected in concentrations of 1 nmol mL−1 and 35 pmol mm−3, by tube and tissue phantom, respectively. In addition to nonfluorescent, PyBODIPYs are non‐phototoxic, photostable, and show high molar extinction coefficients, as well as inertness toward nucleophilic addition. PyBODIPYs are modified with PEG‐400, to improve aqueous solubility and to enable in vivo imaging. Thus, PyBODIPY is an attractive small molecule to use as PA contrast agent, which could be coupled to targeting ligands for in vivo use. In addition, 1H‐pyrrole conjugation might be applied to the design of novel near‐infrared ranged quenchers suitable for PAI, and promote the development of probes for clinical translation.

show abstract

Section: Figurementioning

confidence: 99%

Tuning Optical Properties of BODIPY Dyes by Pyrrole Conjugation for Photoacoustic Imaging

Merkes

Lammers

Kancherla

et al. 2020

Advanced Optical Materials

View full text Add to dashboard Cite

show abstract

“…combination of PAT and US imaging can then provide spectroscopic and anatomical information [34][35][36][37][38][39][40]42,43]. Angiogenesis and lipid accumulation have been shown to be increased in prostate cancer tumors [58,59].…”

mentioning

confidence: 99%

“…Angiogenesis and lipid accumulation have been shown to be increased in prostate cancer tumors [58,59]. In vivo [43] and ex vivo [34,35,41] imaging of human prostates have shown differences between malignant and benign prostate tissue using endogenous contrast. We have recently shown that successful prostate cancer biopsy targeting in ex vivo human prostates is possible using 1064 nm PAT and US imaging [34].…”

mentioning

confidence: 99%

“…While PAT has the potential to provide real-time biopsy targets, current PAT setups have not yet demonstrated the ability to image the full posterior-anterior depth as observed from the rectum with the US transducer [34,35,[41][42][43]. Two locations for the placement of the light delivery source for PAT have been investigated.…”

mentioning

confidence: 99%

“…The first location is placing the light delivery mechanism with the US transducer in the rectum. Simulation studies [60] along with in vivo [42,43] and ex vivo [34] PAT of human prostates have shown that the anterior regions of the prostate do not receive adequate light fluence to detect malignant and benign signal contrast when a rectally-located illumination source is used. The second location, which shows improved potential for PAT of the anterior prostate [60], is to deliver light via the prostatic urethra.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography

Bungart¹,

Cao²,

Yang-Tran³

et al. 2019

Biomed. Opt. Express

View full text Add to dashboard Cite

Current diagnosis of prostate cancer relies on histological analysis of tissue samples acquired by biopsy, which could benefit from real-time identification of suspicious lesions. Photoacoustic tomography has the potential to provide real-time targets for prostate biopsy guidance with chemical selectivity, but light delivered from the rectal cavity has been unable to penetrate to the anterior prostate. To overcome this barrier, a urethral device with cylindrical illumination is developed for whole-prostate imaging, and its performance as a function of angular light coupling is evaluated with a prostate-mimicking phantom.

show abstract

Application of photoacoustic computed tomography in biomedical imaging: A literature review

Sun

Wang

et al. 2022

Bioengineering & Transla Med

View full text Add to dashboard Cite

Photoacoustic computed tomography (PACT) is a hybrid imaging modality that combines optical excitation and acoustic detection techniques. It obtains high‐resolution deep‐tissue images based on the deep penetration of light, the anisotropy of light absorption in objects, and the photoacoustic effect. Hence, PACT shows great potential in biomedical sample imaging. Recently, due to its advantages of high sensitivity to optical absorption and wide scalability of spatial resolution with the desired imaging depth, PACT has received increasing attention in preclinical and clinical practice. To date, there has been a proliferation of PACT systems designed for specific biomedical imaging applications, from small animals to human organs, from ex vivo to in vivo real‐time imaging, and from simple structural imaging to functional and molecular imaging with external contrast agents. Therefore, it is of great importance to summarize the previous applications of PACT systems in biomedical imaging and clinical practice. In this review, we searched for studies related to PACT imaging of biomedical tissues and samples over the past two decades; divided the studies into two categories, PACT imaging of preclinical animals and PACT imaging of human organs and body parts; and discussed the significance of the studies. Finally, we pointed out the future directions of PACT in biomedical applications. With the development of exogenous contrast agents and advances of imaging technique, in the future, PACT will enable biomedical imaging from organs to whole bodies, from superficial vasculature to internal organs, from anatomy to functions, and will play an increasingly important role in biomedical research and clinical practice.

show abstract

Pilot Study of Prostate Cancer Angiogenesis Imaging Using a Photoacoustic Imaging System

Cited by 60 publications

References 14 publications

Tuning Optical Properties of BODIPY Dyes by Pyrrole Conjugation for Photoacoustic Imaging

Tuning Optical Properties of BODIPY Dyes by Pyrrole Conjugation for Photoacoustic Imaging

Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography

Application of photoacoustic computed tomography in biomedical imaging: A literature review

Contact Info

Product

Resources

About