Pilot study of comparative placental morphometry in pre-eclamptic and normotensive pregnancies suggests possible maladaptations of the fetal component of the placenta

Ducray, Jennifer; Naicker, Thajasvarie; Moodley, Jagidesa

doi:10.1016/j.ejogrb.2010.12.038

Cited by 34 publications

(32 citation statements)

References 27 publications

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“…These results are in line with our previous report in rats exposed to reduced uterine perfusion (6) and in women with preeclampsia (15). Interestingly, chronic sFlt-1 infusion into normal pregnant rats increases MAP and decreases fetal weight (5,22), and blockade of sFlt-1 with recombinant VEGF 121 lowers the blood pressure response in placental ischemic rats (9).…”

Section: Discussionsupporting

confidence: 92%

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Reduced uterine perfusion pressure induces hypertension in the pregnant mouse

Intapad

Warrington

Spradley

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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Despite preeclampsia being one of the leading causes of maternal death and a major contributor of maternal and perinatal morbidity, the mechanisms responsible for its pathogenesis have yet to be fully elucidated. Growing evidence indicates that reduced uteroplacental perfusion and the resulting placental ischemia triggers the cascade of events leading to this maternal disorder. While the well-established rat model of reduced uterine perfusion pressure (RUPP) is providing invaluable insight into the etiology of preeclampsia, the aim of this study was to develop a mouse model of reduced uterine perfusion to expand mechanistic investigation by incorporation with novel gene-targeted mice. To accomplish this aim, a sham surgical procedure or a restriction of blood flow at the abdominal aorta and the ovarian arteries was initiated at day 13 of gestation in C57BL/6J mice. Mean arterial pressure measured in conscious, chronically instrumented mice was significantly elevated in the RUPP (120 ± 4 mmHg) compared with the sham (104 ± 4 mmHg) mice at day 18 of gestation (P < 0.01). Placental ischemia reduced fetal weights (0.95 ± 0.04 and 0.80 ± 0.02 g; RUPP vs. Sham, respectively; P < 0.02) and increased circulating levels of antiangiogenic soluble fms-related tyrosine kinases (sFlt)-1 (P < 0.05) in the RUPP at day 18 of gestation. Plasma concentrations of sFlt-1 are increased in preeclamptic patients and in response to reduced uterine perfusion in the rat. Thus, these results suggest that the mouse model of reduced uterine perfusion is applicable to facilitate novel mechanistic investigation into the etiology of hypertension that results from placental ischemia during pregnancy.

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Section: Discussionsupporting

confidence: 92%

“…The prevailing hypothesis for the initiation of preeclampsia is reduced uteroplacental perfusion, thought to arise from incomplete remodeling of the maternal uterine spiral arteries (6,11,20). This reduced perfusion of the placenta results in placental ischemia.…”

Section: Discussionmentioning

confidence: 98%

Reduced uterine perfusion pressure induces hypertension in the pregnant mouse

Intapad

Warrington

Spradley

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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“…In pre‐eclampsia, this invasion is limited to the proximal decidua, and spiral arteries fail to dilate and remain responsive to vasomotor influences, which leads to high‐resistance chorioplacental circulation . As a result, the average diameter of the blood vessels decreases and, owing to the placental ischemia accelerating villous branching, causes an increase in total villi volume, and occurrence of numerous syncytial knots (apoptotic cell clusters) associated with diffusion and villitis . In contrast to the previous findings, there was no significant difference in mean volume of villi between the control and the pre‐eclamptic groups.…”

Section: Discussioncontrasting

confidence: 65%

Role of vascular endothelial growth factor and placental growth factor expression on placenta structure in pre‐eclamptic pregnancy

Kurtoğlu

Altunkaynak

Aydin

et al. 2015

J of Obstet and Gynaecol

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“…These changes lead to poor placentation, which is the first step in the development of pre‐eclampsia. It has been shown that there is a significant difference in the density of placental villus arrangement between normotensive and pre‐eclamptic placentas . This may have an effect on the stiffness and elasticity of the placenta.…”

Section: Introductionmentioning

confidence: 99%