Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes

Aoki, Kosuke; Nakao, Atsunori; Adachi, Tsutomu; Matsui, Yasuji; Miyakawa, Shumpei

doi:10.1186/2045-9912-2-12

Cited by 105 publications

(160 citation statements)

References 27 publications

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“…Recently, it has been reported that H 2 can improve various diseases such as metabolic diseases, cardiovascular diseases and neurodegenerative diseases via several physiological functions including anti-oxidative and anti-inflammatory effects [21,22]. In the sports science field, although several studies have been reported on the influence of H 2 intake on exercise-induced oxidative stress and other biomarkers (e.g., inflammatory markers, muscle damage markers, and energy substrates), the findings on the effectiveness of H 2 were fragmentary [23,24,25,34].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to conventional antioxidants, it has been suggested that molecular hydrogen (H 2 ) can act as an antioxidant. Although almost all studies investigated the effectiveness of H 2 ingestion on various diseases and disease models that are related to oxidative stress [20,21], little is known about the influence of H 2 on exercise-induced oxidative stress [22,23]. We previously reported that H 2 ingestion after downhill running can be effective for the reduction of DOMS, whereas it did not affect the muscle damage, inflammation, and oxidative stress markers in blood [24].…”

Section: Introductionmentioning

confidence: 99%

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Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath

et al. 2018

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The purpose of this study was to investigate the involvement of neutrophil dynamics and function in exercise-induced muscle damage (EIMD) and delayed-onset muscle soreness (DOMS), and the effect of molecular hydrogen (H2) intake on these parameters. Nine healthy and active young men performed H2 and placebo bath trial in a crossover design. They carried out downhill running (−8% slope) for 30 min at a speed corresponding to 75~85% of peak oxygen uptake (VO2peak). Subsequently, they repeated bathing for 20 min per day for one week. Degree of muscle soreness (visual analogue scale: VAS), peripheral leukocyte counts, neutrophil dynamics and function, muscle damage, and inflammation markers were measured. Plasma interleukin (IL)-6 concentration was significantly correlated with peripheral neutrophil count, VAS, and serum creatine kinase activity, respectively, after downhill running. Peripheral neutrophil count and serum myoglobin concentration were also significantly correlated. Conversely, there were no effects of H2 bath. These results suggest that IL-6 may be involved in the mobilization of neutrophils into the peripheral blood and subsequent EIMD and DOMS after downhill running; however, it is not likely that H2 bath is effective for the inflammatory process that is centered on neutrophils after downhill running.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath

et al. 2018

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“…In human, however, intestinal bacteria produce a large quantity of H 2 [2] and it was a common belief that the implied sufficiency and possibly continuous availability precluded any beneficial effects of the internal H 2 on human health, except perhaps in some anecdotal miracle healing water stories. Recently, however, extensive research on medical H 2 in the areas of cell biology, animal disease models and others have introduced irrefutable evidences [3,4] that medical treatment with H 2 is feasible on human diseases. However, since H 2 exists in the close environment and in human body itself, it cannot be therapeutic to human disease unless it reaches the diseased areas much closer or directly.…”

Section: Introductionmentioning

confidence: 99%

“…We concluded at that time that H 2 treatment, when it was combined with other medications, provided some visible benefits to a very selective and small number of brainstem infarction patients [4]. …”

Section: Introductionmentioning

confidence: 99%

A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level

Ono¹,

Nishijima²,

Adachi³

et al. 2012

Med Gas Res

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BackgroundIn animal experiments, use of molecular hydrogen ( H2) has been regarded as quite safe and effective, showing benefits in multiple pathological conditions such as ischemia-reperfusion injury of the brain, heart, kidney and transplanted tissues, traumatic and surgical injury of the brain and spinal cord, inflammation of intestine and lung , degenerative striatonigral tissue and also in many other situations. However, since cerebral ischemia patients are in old age group, the safety information needs to be confirmed. For the feasibility of H2 treatment in these patients, delivery of H2 by inhalation method needs to be checked for consistency.MethodsHydrogen concentration (HC) in the arterial and venous blood was measured by gas chromatography on 3 patients, before, during and after 4% (case 1) and 3% (case2,3) H2 gas inhalation with simultaneous monitoring of physiological parameters. For a consistency study, HC in the venous blood of 10 patients were obtained on multiple occasions at the end of 30-min H2 inhalation treatment.ResultsThe HC gradually reached a plateau level in 20 min after H2 inhalation in the blood, which was equivalent to the level reported by animal experiments. The HC rapidly decreased to 10% of the plateau level in about 6 min and 18 min in arterial and venous blood, respectively after H2 inhalation was discontinued. Physiological parameters on these 3 patients were essentially unchanged by use of hydrogen. The consistency study of 10 patients showed the HC at the end of 30-min inhalation treatment was quite variable but the inconsistency improved with more attention and encouragement.ConclusionH2 inhalation of at least 3% concentration for 30 min delivered enough HC, equivalent to the animal experiment levels, in the blood without compromising the safety. However, the consistency of H2 delivery by inhalation needs to be improved.

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“…Adequate hydration with hydrogen-rich water decreases blood lactate levels and improved function of muscle in athletes [78]. …”

Section: Introductionmentioning

confidence: 99%

Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia

Ghanizadeh

Berk

2013

Med Gas Res

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Hydrogen gas is a bioactive molecule that has a diversity of effects, including anti-apoptotic, anti-inflammatory and anti-oxidative properties; these overlap with the process of neuroprogression in major psychiatric disorders. Specifically, both bipolar disorder and schizophrenia are associated with increased oxidative and inflammatory stress. Moreover, lithium which is commonly administered for treating bipolar disorder has effects on oxidative stress and apoptotic pathways, as do valproate and some atypical antipsychotics for treating schizophrenia. Molecular hydrogen has been studied pre-clinically in animal models for the treatment of some medical conditions including hypoxia and neurodegenerative disorders, and there are intriguing clinical findings in neurological disorders including Parkinson’s disease. Therefore, it is hypothesized that administration of hydrogen molecule may have potential as a novel therapy for bipolar disorder, schizophrenia, and other concurrent disorders characterized by oxidative, inflammatory and apoptotic dysregulation.

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Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes

Cited by 105 publications

References 27 publications

Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath

Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath

A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level

Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia

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