Pilot Investigation of the Association Between Serum Stress Neuropeptide Levels and Lymphocyte Expression of Fas and Fas Ligand in Critical Illness

Papathanassoglou, Elizabeth; Mpouzika, Meropi; Giannakopoulou, Margarita; Bozas, Evangelos; Middleton, Nicos; Boti, Sofia; Karabinis, Andréas

doi:10.1177/1099800414542871

Cited by 8 publications

(4 citation statements)

References 47 publications

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“…In critically ill patients, the level of NPY is positively correlated with the total number of lymphocytes, T helper (Th) cells, and toxic T cells ( 53 ). Furthermore, serum NPY is negatively correlated with the expression of apoptosis-related molecule Fas/Fas ligand in Th cells and cytotoxic T cells, and negatively correlated with the expression of Fas in B cells ( 54 ). Early studies demonstrated that NPY (10 −12 –10 −6 M) facilitates the proliferation of human colonic lamina propria lymphocytes by promoting the production of IL-1β in monocytes ( 55 ).…”

Section: Npy Directly Regulates Immune Cellsmentioning

confidence: 99%

Neuropeptide Y Is an Immunomodulatory Factor: Direct and Indirect

Chen

Liu

et al. 2020

Front. Immunol.

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Neuropeptide Y (NPY), which is widely distributed in the nervous system, is involved in regulating a variety of biological processes, including food intake, energy metabolism, and emotional expression. However, emerging evidence points to NPY also as a critical transmitter between the nervous system and immune system, as well as a mediator produced and released by immune cells. In vivo and in vitro studies based on gene-editing techniques and specific NPY receptor agonists and antagonists have demonstrated that NPY is responsible for multifarious direct modulations on immune cells by acting on NPY receptors. Moreover, via the central or peripheral nervous system, NPY is closely connected to body temperature regulation, obesity development, glucose metabolism, and emotional expression, which are all immunomodulatory factors for the immune system. In this review, we focus on the direct role of NPY in immune cells and particularly discuss its indirect impact on the immune response.

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Section: Npy Directly Regulates Immune Cellsmentioning

confidence: 99%

Neuropeptide Y Is an Immunomodulatory Factor: Direct and Indirect

Chen

Liu

et al. 2020

Front. Immunol.

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“…It is a self-reported questionnaire including forty stressful factors, for which patients are called to refer how stressful there are during their hospitalization to ICU; it was validated for use in Greek through a translation and back-translation process. [10] Its Cronbach's α estimation was α = 0.84.…”

Section: Methodsmentioning

confidence: 99%

Factors Affecting Stress Levels in Hospitalized Patients after Implementation of Fast.track Protocol in Hepatopancreatobiliary Surgery

Kapritsou

Korkolis

Giannakopoulou

et al. 2020

Asia-Pacific Journal of Oncology Nursing

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Objective:The objective was to explore factors affecting stress levels in hospitalized patients after implementation of fast-track (FT) protocol in hepatopancreatobiliary surgery.Methods:This was a prospective cross-sectional study, where 90 patients were included. Exploration of environmental postoperative stress levels was conducted by serum adrenocorticotropic hormone and cortisol levels, the Intensive Care Unit Environmental Stressor Scale, and three self-reported Numeric Analog Scale questions, with regard to emotional/stress level, specifically “How sad do you feel right now?” “How stressed do you feel right now?” and “How optimistic do you feel right now, about the future?” at 3 time points: (T1) Before surgery, (T2) the day of surgery, and (T3) the 3rd postoperative day. The trial profile is conformed according to the CONSORT guidelines. Statistical analysis was carried out by SPSS software version 22 (IBM SPSS software, Chicago, Illinois, USA) at a significance level of 0.05.Results:Serum cortisol T2 levels were positively correlated with the day of removal the drainage tube (rho = 0.235, P = 0.027). Furthermore, serum cortisol T3 levels were positively correlated with age and body mass index and negatively with the day of drainage tube removal (rho = 0.231, P = 0.028, rho = 0.235, P = 0.026, and rho = −0.279, P = 0.008, respectively).Conclusions:The findings of this study highlight that after evaluation of stress levels; nurses could interfere and reduce stress levels, knowing the factors which cause the increased stress levels, after the implementation of FT protocols.

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“…Zung and BPS scales have already been adapted to the Greek language and evaluated their validity and consistency (Kletsiou 2012; Mpouzika et al 2013; Papathanassoglou et al 2015) and calculated the internal consistency Cronbach’s α index, whose values were adequate:…”

Section: Methodsmentioning

confidence: 99%

Postoperative stress and pain response applying fast-track protocol in patients undergoing hepatectomy

Kapritsou

Evangelos

Dimitris

et al. 2018

Journal of Perioperative Practice

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Aim To assess the clinical parameters and compare the stress and pain response between fast-track recovery protocol and conventional treatment in patients undergoing major liver resection. Methods Eighty-eight patients suffering from malignant liver tumours were surgically treated from May 2012 to March 2015. After randomisation, they were prospectively divided into two groups: group fast-track patients (n = 46) and group conventional treatment patients (n = 42). Demographic and clinical data were collected and patients were assessed with pain scale (behavioural observation scale and visual analog scale), while depression levels were evaluated with Zung self-rating depression scale and three Numeric Analog Scale self-reported questions. Peripheral blood samples were collected at time points: T1 on the admission day, T2 on the day of surgery and T3 on the day of discharge examining serum levels of adrenocorticotropic hormone and cortisol. Conclusion Fast-track recovery protocols seem to be associated with improvement in several clinical parameters, without compromising, biologic or emotional stress in patients undergoing major liver resection.

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Pilot Investigation of the Association Between Serum Stress Neuropeptide Levels and Lymphocyte Expression of Fas and Fas Ligand in Critical Illness

Abstract: Results suggest a potential role for stress neuropeptides in lymphocyte survival and activation in critical illness.

Cited by 8 publications

References 47 publications

Neuropeptide Y Is an Immunomodulatory Factor: Direct and Indirect

Neuropeptide Y Is an Immunomodulatory Factor: Direct and Indirect

Factors Affecting Stress Levels in Hospitalized Patients after Implementation of Fast.track Protocol in Hepatopancreatobiliary Surgery

Postoperative stress and pain response applying fast-track protocol in patients undergoing hepatectomy

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