Pilomatricoma-like changes in the epidermal cysts of Gardner's syndrome

Cooper, Philip H.; Fechner, Robert E.

doi:10.1016/s0190-9622(83)70071-x

Cited by 110 publications

(50 citation statements)

References 10 publications

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“…The pilomatricoma-like changes are observed either in form of columns of ghost cells adherent to the cystic epithelial lining and projecting into the lumen, or as scattered intraluminal or mural ghost cell aggregates [8]. Similar findings have been published by Narisawa and Kohda [9], and Urabe et al [10].…”

Section: Introductionsupporting

confidence: 79%

“…This basophilic/transitional cell zone was not observed in the ghost cell deposits scattered within the connective tissue wall of our odontogenic lesion. Calcifications were seen in 8/20 (40 %) of ECs with mural pilomatricoma-like changes but in none of the cases with luminal deposits of ghost cells [8]. Interestingly, in the study by Cooper and Fechner [8] the pericystic deposits of shadow cells were invariably associated with a giant cell reaction of foreign body type.…”

Section: Discussionmentioning

confidence: 90%

“…Cooper and Fechner [8] have reported that 36/57 (63 %) ECs in patients with GS showed extensive pilomatricoma-like changes in the form of columns of ghost cells (21/57, 37 %), scattered intraluminal masses of ghost cells (29/57, 51 %), or pericystic (mural) ghost cells aggregates (20/57, 35 %) [8]. A multi-layered, transitional zone of basophilic epithelial cells was present at the base of the columnar aggregates of ghost cells [8]. This basophilic/transitional cell zone was not observed in the ghost cell deposits scattered within the connective tissue wall of our odontogenic lesion.…”

Section: Discussionmentioning

confidence: 99%

“…ECs are observed in 65 % of patients with GS [1,3] and frequently precede the intestinal polyps [29]. Cooper and Fechner [8] have reported that 36/57 (63 %) ECs in patients with GS showed extensive pilomatricoma-like changes in the form of columns of ghost cells (21/57, 37 %), scattered intraluminal masses of ghost cells (29/57, 51 %), or pericystic (mural) ghost cells aggregates (20/57, 35 %) [8]. A multi-layered, transitional zone of basophilic epithelial cells was present at the base of the columnar aggregates of ghost cells [8].…”

Section: Discussionmentioning

confidence: 99%

“…Cooper and Fechner [8] reported that approximately 63 % of ECs associated with GS exhibit pilomatricomatype ghost cell keratinization. The pilomatricoma-like changes are observed either in form of columns of ghost cells adherent to the cystic epithelial lining and projecting into the lumen, or as scattered intraluminal or mural ghost cell aggregates [8].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Orthokeratinized Odontogenic Cyst with an Associated Keratocystic Odontogenic Tumor Component and Ghost Cell Keratinization and Calcifications in a Patient with Gardner Syndrome

Argyris

Koutlas

2016

Head and Neck Pathol

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Gardner syndrome (GS) is caused by mutations in the APC and besides adenomatous colorectal polyps includes such manifestations as osteomas, epidermoid cysts (ECs) and occasionally multiple pilomatricomas. More than 50 % of ECs in patients with GS exhibit pilomatricoma-like ghost cell keratinization. The latter may be explained by the fact that the development of both GS and pilomatricoma is driven by activation of the Wnt/b-catenin signaling pathway. A 62-year-old, Caucasian male with history of GS presented with a unilocular, mixed radiopaque/radiolucent mandibular lesion causing divergence and external root resorption of involved teeth. Histopathologically, the lesion was composed of two cystic components, an orthokeratinized odontogenic cyst (OOC) and a smaller one with characteristics of keratocystic odontogenic tumor (KCOT) featuring, focally, ghost cells and an epithelial morule-like structure. Dystrophic calcifications essentially similar to those seen in pilomatricomas were observed in the fibrous connective tissue wall. The KCOT and OOC epithelia revealed strong and diffuse cytokeratin (AE1/AE3) and b-catenin immunoreactivity. CD10 positive immunostaining was seen in the keratin and superficial spinous cell layers in both OOC and KCOT. The intraepithelial and mural ghost cells showed a cytokeratin (?), b-catenin and CD10 (-) immunophenotype. The diagnosis of OOC with ghost cell calcifications in association with KCOT was rendered. The patient was lost to follow-up. Although a coincidental co-existence cannot be excluded, ghost cell calcifications mimicking pilomatricoma-like changes in an unusual odontogenic cyst combining OOC and KCOT features as seen in this patient with GS may be explained by the common molecular mechanisms underlying the pathogenesis of cutaneous pilomatricomas and GS.

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Section: Introductionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Orthokeratinized Odontogenic Cyst with an Associated Keratocystic Odontogenic Tumor Component and Ghost Cell Keratinization and Calcifications in a Patient with Gardner Syndrome

Argyris

Koutlas

2016

Head and Neck Pathol

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Genetics of Nonmelanoma Skin Cancer

Tsao

2001

Arch Dermatol

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Solitary Hard Nodule on the Forearm

Schweitzer

Goldin²,

Bronson³

et al. 1989

Arch Dermatol

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A 57-year-old man presented with a 2-year history of a slowly enlarging, asymptomatic nodule on the right forearm. There was no history of trauma to the area, and the patient's medical history was otherwise insignificant.Physical examination disclosed a 2.0 X 2.5-cm, erythematous, hard, freely mobile, elevated nodule on the anterior aspect of the proximal right forearm (Fig 1). No lymphadenopathy was present. The remainder of the physical examination was normal.Representative sections of an excisional biopsy specimen are shown (Figs 2 and 3).What is your diagnosis? Figure 1.Figure 2.Figure 3.Clinicians, local and regional societies, and residents and fellows in dermatology are invited to submit quiz cases to this section. Cases should follow the established pattern and be submitted double-spaced and in triplicate. Photomicrographs and illustrations must be clear and submitted as positive color transparencies (35 mm). Do not submit color prints unless accompanied by original transparencies. If photomicrographs are not available, the actual slide from the specimen will be acceptable.

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Pilomatricoma-like changes in the epidermal cysts of Gardner's syndrome

Cited by 110 publications

References 10 publications

Orthokeratinized Odontogenic Cyst with an Associated Keratocystic Odontogenic Tumor Component and Ghost Cell Keratinization and Calcifications in a Patient with Gardner Syndrome

Orthokeratinized Odontogenic Cyst with an Associated Keratocystic Odontogenic Tumor Component and Ghost Cell Keratinization and Calcifications in a Patient with Gardner Syndrome

Genetics of Nonmelanoma Skin Cancer

Solitary Hard Nodule on the Forearm

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