Pilocarpine Spray for the Treatment of Xerostomia: a Randomized, Double-Blind, Placebo-Controlled Trial

Pólvora, Tábata Larissa Santos; Pereira, Raony Môlim de Sousa; Macedo, Ana Paula; Macedo, Leandro Dorigan de; Motta, Ana Carolina Fragoso; Tirapelli, Camila; Pedrazzi, Vinícius

doi:10.1016/j.oooo.2018.02.057

Cited by 3 publications

(2 citation statements)

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“…Significant enhancements in both stimulated and unstimulated salivary flow rates were noted in patients with residual functioning salivary tissue when they used pilocarpine, even though three patients discontinued early due to adverse events. In a clinical trial conducted by the team of Santos Polvora, which employed a prospective, randomized, double-blind, crossover, and placebo-controlled design, a marked elevation in salivary flow was recorded in participants treated with a pilocarpine spray [ 75 ]. However, these findings conflict with Pereira et al’s study, where the pilocarpine spray’s efficacy was similar to the placebo in 40 patients with radiation-induced xerostomia [ 76 ].…”

Section: Natural Products Used For the Treatment Of Xerostomiamentioning

confidence: 99%

A Review of the Role of Natural Products as Treatment Approaches for Xerostomia

Kontogiannopoulos,

Kapourani,

Gkougkourelas

et al. 2023

Pharmaceuticals

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Xerostomia, commonly known as dry mouth, is a widespread oral health malfunction characterized by decreased salivary flow. This condition results in discomfort, impaired speech and mastication, dysphagia, heightened susceptibility to oral infections, and ultimately, a diminished oral health-related quality of life. The etiology of xerostomia is multifaceted, with primary causes encompassing the use of xerostomic medications, radiation therapy to the head and neck, and systemic diseases such as Sjögren’s syndrome. Consequently, there is a growing interest in devising management strategies to address this oral health issue, which presents significant challenges due to the intricate nature of saliva. Historically, natural products have served medicinal purposes, and in contemporary pharmaceutical research and development, they continue to play a crucial role, including the treatment of xerostomia. In this context, the present review aims to provide an overview of the current state of knowledge regarding natural compounds and extracts for xerostomia treatment, paving the way for developing novel therapeutic strategies for this common oral health issue.

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Section: Natural Products Used For the Treatment Of Xerostomiamentioning

confidence: 99%

A Review of the Role of Natural Products as Treatment Approaches for Xerostomia

Kontogiannopoulos,

Kapourani,

Gkougkourelas

et al. 2023

Pharmaceuticals

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show abstract

“…Both stimulated and unstimulated salivary flow rates appeared to be ameliorated in all patients with residual functioning salivary tissue having utilized pilocarpine, despite an early withdrawal of three-prior to the time defined as sufficient for conclusions-because of adverse side effects, such as diarrhea, constipation and increased dryness of the mouth. In addition, when the effectiveness of a pilocarpine spray as a treatment for xerostomia through a prospective, randomized, double-blind, crossover, placebo-controlled clinical trial was examined by the research team of Santos Polvora [87], the salivary flow of the pilocarpine-treated participants was significantly increased after the utilization of the spray. Yet, it is worth mentioning that these results are in disagreement with the findings of the study carried out by Pereira et al [88], according to which the performance of the evaluated pilocarpine spray was similar to that of the placebo on the patient's stimulated whole saliva flow.…”

Section: Topical Administration Of Pilocarpinementioning

confidence: 99%

A Review on the Role of Pilocarpine on the Management of Xerostomia and the Importance of the Topical Administration Systems Development

2022

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Xerostomia is linked to an increased risk of dental caries, oral fungal infections, and speaking/swallowing difficulties, factors that may significantly degrade patients’ life, socially- or emotionally-wise. Consequently, there is an increasing interest in developing management approaches for confronting this oral condition, at which pilocarpine, a parasympathomimetic agent, plays a vital role. Although the therapeutic effects of orally administrated pilocarpine on the salivary gland flow and the symptoms of xerostomia have been proved by numerous studies, the systemic administration of this drug is affiliated with various adverse effects. Some of the typical adverse effects include sweating, nausea, vomiting, diarrhea, rhinitis, dizziness and increased urinary frequency. In this vein, new strategies to develop novel and effective dosage forms for topical (i.e., in the oral cavity) pilocarpine administration, in order for the salivary flow to be enhanced with minimal systemic manifestations, have emerged. Therefore, the purpose of the current review is to survey the literature concerning the performance of topical pilocarpine delivery systems. According to the findings, the topical delivery of pilocarpine can be regarded as the equivalent to systemic delivery of the drug, efficacy-wise, but with improved patient tolerance and less adverse effects.

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Xerostomia: Advances and Challenges in Drug Development

Kim

2024

CDT

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Pilocarpine Spray for the Treatment of Xerostomia: a Randomized, Double-Blind, Placebo-Controlled Trial

Cited by 3 publications

References 0 publications

A Review of the Role of Natural Products as Treatment Approaches for Xerostomia

A Review of the Role of Natural Products as Treatment Approaches for Xerostomia

A Review on the Role of Pilocarpine on the Management of Xerostomia and the Importance of the Topical Administration Systems Development

Xerostomia: Advances and Challenges in Drug Development

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