Pilo-Sebaceous Duct Obstruction and Acne

Holmes, Robert L.; Williams, M.; Cunliffe, W. J.

doi:10.1111/j.1365-2133.1972.tb07418.x

Cited by 81 publications

(48 citation statements)

References 14 publications

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“…The further studies of Plewig et al [18]and Holmes et al [19]showed that even normal-looking skin from acne patients may already be developing very early microcomedones; this was further supported by the work of Cunliffe et al [20]using in situ hybridisation techniques. This observation is of clinical significance since it stresses the need to apply topical therapies, not just to acne lesions but also to the normal-looking skin of the acne-prone areas.…”

Section: Comedone Formationsupporting

confidence: 52%

Looking Back to the Future – Acne

Wj¹

2002

Dermatology

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Section: Comedone Formationsupporting

confidence: 52%

Looking Back to the Future – Acne

Wj¹

2002

Dermatology

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“…Such evaluations were made on CFB taken from symmetrical sites of the forehead at the baseline visit as well as after 2, 4 and 6 weeks of treatment. CFB was developed as an extension of skin surface stripping and refers to a non-invasive collection of stratum corneum and follicular material using cyanoacrylate adhesive [16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26]. The follicular casts so sampled from the upper portion of a follicular duct reflect the balance between comedo formation and lysis.…”

Section: Methodsmentioning

confidence: 99%

Split-Face Clinical and Bio-Instrumental Comparison of 0.1% Adapalene and 0.05% Tretinoin in Facial Acne

Piérard-Franchimont¹,

Henry²,

Fraiture³

et al. 1999

Dermatology

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Background: Adapalene and tretinoin are topical compounds active for treating acne. Objective: To compare the efficacity and safety of adapalene 0.1% gel and tretinoin 0.05% gel in moderately severe facial acne using clinical and objective biometrological assessments. Such information is currently lacking in the literature. Methods: The split-face method was used in 25 acne volunteers for a 6-week treatment. In addition to clinical counts of lesions, the amount of comedones was assessed using computer-assisted morphometry of cyanoacrylate follicular biopsies. The erythema index and squamometry values were used to quantitate skin irritation. Results: The tretinoin formulation brought better comedolysis and clinical improvement than the adapalene formulation. Erythema was transiently more pronounced on the tretinoin-treated side. Squamometry yielded no significant difference between both products. Conclusion: Tretinoin 0.05% gel exhibits a greater anti-acne efficacy than adapalene 0.1% gel, although with temperate tolerability.

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“…Comedogenesis is due to the accumulation of corneocytes in the pilosebaceous duct [5]. This could be due to hyperproliferation of ductal keratinocytes, inadequate separation of the ductal corneocytes or a combination of both factors [6].…”

Section: Aetiology Of Comedogenesismentioning

confidence: 99%

Comedogenesis: Some Aetiological, Clinical and Therapeutic Strategies

et al. 2003

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Hypercornification is an early feature of acne and usually precedes inflammation. It is associated with ductal hyperproliferation, and there are many controlling factors such as androgens, retinoids, sebum composition and cytokines. Cycling of normal follicles and of comedones may explain the natural resolution of comedones and, in the longer term, resolution of the disease itself. There is a need to tailor treatment according to comedonal type. Suboptimal therapy can often result from inappropriate assessments of comedones, especially microcomedones, sandpaper comedones, submarine comedones and macrocomedones. Macrocomedones can produce devastating acne flares, particularly if patients are inappropriately prescribed oral isotretinoin. Gentle cautery under topical local anaesthesia is a useful therapy in the treatment of such lesions. The newer retinoids and new formulations of all-trans-retinoic acid show a better benefit/risk ratio.

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Pilo-Sebaceous Duct Obstruction and Acne

Cited by 81 publications

References 14 publications

Looking Back to the Future – Acne

Looking Back to the Future – Acne

Split-Face Clinical and Bio-Instrumental Comparison of 0.1% Adapalene and 0.05% Tretinoin in Facial Acne

Comedogenesis: Some Aetiological, Clinical and Therapeutic Strategies

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