Pigs as an experimental model for systemic Mycobacterium avium infectious disease

Hibiya, Kenji; Furugen, Makoto; Higa, Futoshi; Tateyama, Masao; Fujita, Jiro

doi:10.1016/j.cimid.2011.09.001

Cited by 7 publications

(3 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Not all subspecies of M. avium will infect humans (Hibiya et al, 2011). Therefore, additional work is necessary to identify human-relevant subsets of MAC in rainwater tank samples.…”

Section: Discussionmentioning

confidence: 99%

Public health implications of Acanthamoeba and multiple potential opportunistic pathogens in roof-harvested rainwater tanks

Hamilton

Ahmed

Palmer

et al. 2016

Environmental Research

View full text Add to dashboard Cite

“…Not all subspecies of M. avium will infect humans (Hibiya et al, 2011). Therefore, additional work is necessary to identify human-relevant subsets of MAC in rainwater tank samples.…”

Section: Discussionmentioning

confidence: 99%

Public health implications of Acanthamoeba and multiple potential opportunistic pathogens in roof-harvested rainwater tanks

Hamilton

Ahmed

Palmer

et al. 2016

Environmental Research

View full text Add to dashboard Cite

“…The presence of unorganized granulomas composed of foamy histiocytes packed with numerous AFB has been reported to represent the typical histological characteristics of disseminated lesions caused by M. avium infection (3,12). In contrast, previous studies have shown that most localized pulmonary lesions developing after the initiation of ART display organized granulomas with scarce AFB (6).…”

Section: Discussionmentioning

confidence: 71%

Acquired Immune-deficiency Syndrome with Focal Onset of <i>Mycobacterium avium</i> Infection Displaying a Histological/Genetic Pattern of Disseminated Mycobacteria

et al. 2012

Self Cite

View full text Add to dashboard Cite

A 66-year-old man with human immunodeficiency virus (HIV) infection was admitted for treatment of Pneumocystis pneumonia. Upon admission, a tumor mass adjacent to the thoracic descending aorta was revealed on computed tomography. Histology revealed an exudative granuloma with histiocytes packed with numerous acid-fast bacilli. Mycobacterium avium was isolated from the tissue. A genetic examination of the isolates demonstrated this strain to be located in the cluster consisting of strains that cause systemic infection. The patient's baseline CD4 + cell count was 9/μL and the HIV-RNA viral load was 43,800 copies/mL. This case suggests the possibility of a localized onset of disseminated M. avium infection.

show abstract

“…Animal models are key elements in evaluating pathogenicity and virulence of various bacterial and viral agents (Horvat, 2009;Ross et al, 2012;Hibiya et al, 2011;Munson et al, 2012;McConnell et al, 2013;Uzal and McClane, 2012). While the mouse model is a sufficient animal model for most human infectious diseases (Yi and Li, 2012;Hviid et al, 2010;Williams et al, 2009;Drescher and Sosnowska, 2008;Groschup and Buschmann, 2008;Zhang and Moss, 2012;Shi et al, 2011), increasing attempts are being made to use animal models more applicable to zoonotic and animal diseases (Kahn, 2012).…”

Section: Introductionmentioning

confidence: 99%

Flow Cytometry Baseline on Peripheral Leukocyte Cell Profiles for Dairy Goat Kids

Fletcher

Vogt

Pirner

et al. 2013

American Journal of Animal and Veterinary Sciences

View full text Add to dashboard Cite

Small ruminants, like goats, would make excellent animal models for not only infectious diseases in large ruminants but also analogous diseases in humans, such as human tuberculosis, Crohn's disease, melioidosis and brucellosis. The main disadvantage for the small ruminant model is the lack of sufficient baseline data on normal, healthy goat kids. Furthermore, most reagents (antibodies and the like) were not developed for goats or sheep. It is important to demonstrate that available resources, especially from the bovine system, cross-react with the caprine and/or ovine system. Finally, potential breed differences have to be evaluated before goat or sheep studies are compared. In this study, leukocyte cell populations were defined in twenty-six dairy goat kids via flow cytometry. We report no significant differences between three breeds of dairy goat kids and demonstrate the effective use of various antibodies for caprine immune cell markers. No breed-specific differences were detected for any leukocyte cell population or for markers specific for various antigen-presenting cells or T cell populations. Interestingly, however, statistical significant differences were found for leukocyte cell populations for the two different time points two weeks apart presented in this study.

show abstract

Pigs as an experimental model for systemic Mycobacterium avium infectious disease

Cited by 7 publications

References 95 publications

Public health implications of Acanthamoeba and multiple potential opportunistic pathogens in roof-harvested rainwater tanks

Public health implications of Acanthamoeba and multiple potential opportunistic pathogens in roof-harvested rainwater tanks

Acquired Immune-deficiency Syndrome with Focal Onset of <i>Mycobacterium avium</i> Infection Displaying a Histological/Genetic Pattern of Disseminated Mycobacteria

Flow Cytometry Baseline on Peripheral Leukocyte Cell Profiles for Dairy Goat Kids

Contact Info

Product

Resources

About