Pigmented Conjunctival Cysts Following Tetracycline/Minocycline Therapy

Messmer, Elmar P.; Font, Ramon L.; Sheldon, G. C.; Murphy, Daniel R.

doi:10.1016/s0161-6420(83)34377-3

Cited by 42 publications

(7 citation statements)

References 22 publications

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“…Conjunctival deposits, which appear as unpigmented and pigmented cystic epithelial inclusions, have been reported following prolonged (> 10 years) systemic tetracycline/minocycline therapy (Brothers & Hidayat 1981;Messmer et al 1983). Transient myopia has also been described as a rare complication of tetracycline therapy (Edwards 1963).…”

Section: Tetracyclinesmentioning

confidence: 99%

Clinically Important Ocular Reactions to Systemic Drug Therapy

Rennie

1993

Drug Safety

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Many systemically administered drugs produce ocular adverse effects. Fortunately, relatively few are capable of causing significant, irreversible visual impairment. It is the responsibility of every clinician when prescribing systemic therapeutic agents to be aware of potential adverse ocular reactions, to appreciate their significance, and to inform the patient of the potential risks of treatment. In instances where serious adverse reactions relate to the cumulative effects of prolonged treatment, it is the responsibility of the prescribing physician to institute appropriate methods of visual screening. In this respect, it is most important to obtain the necessary individual baseline measurements before treatment is commenced. Chloroquine retinopathy is probably the most feared of all adverse ocular reactions to systemic drug therapy. However, it occurs only rarely if the daily dosage of chloroquine does not exceed 250mg. Regular screening using automated perimetry is mandatory if prolonged therapy is contemplated. Amiodarone almost inevitably produces corneal deposits. These rarely produce symptoms, and resolve upon withdrawal of the drug. Optic neuropathy has recently been described with amiodarone. Systemic anticoagulant therapy may be associated with intraocular hemorrhage in patients with pre-existing disciform macular degeneration, and such agents should be used with caution in affected individuals. Systemic corticosteroids produce posterior subcapsular cataracts in susceptible individuals which may profoundly affect visual acuity. Although elevated intraocular pressure may also result from systemic therapy, the relationship between the pressure rise and development of glaucomatous changes remains unclear. Ethambutol may produce optic neuropathy if the daily dosage exceeds 15 mg/kg. The changes are usually reversible within a few weeks of stopping treatment. High doses of tamoxifen may produce a maculopathy with loss of visual acuity, if given for prolonged periods. The risk must be weighed against the benefits of treatment. Patients receiving more than 800 mg/day of thioridazine have developed retinopathy, which is usually reversible if detected early enough. Tricyclic antidepressants and other agents with anticholinergic properties may cause disturbances of accommodation and pupillary dilatation. The latter may rarely precipitate acute angle closure glaucoma in susceptible individuals.

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Section: Tetracyclinesmentioning

confidence: 99%

Clinically Important Ocular Reactions to Systemic Drug Therapy

Rennie

1993

Drug Safety

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“…They described the deposits as laminated concretions within cysts. Messmer et al expanded the histopathological spectrum to include clinically pigmented and non‐pigmented cysts in a patient treated with tetracycline‐minocycline for acne . Their findings were virtually identical to those described by Brothers and Hidayat in that the pigmented cysts contained deposits with laminated concretions.…”

mentioning

confidence: 66%

“…Hyperpigmentation of the skin and teeth associated with chronic doxycycline is well recognized and there are prior reports of conjunctival pigmented lesions associated with other tetracycline class antibiotics . Conjunctival hyperpigmentation associated with doxycycline, however, has not been well described.…”

mentioning

confidence: 99%

Doxycycline‐associated conjunctival cysts

Tainsh

Wolkow

Yoon

2019

Clinical Exper Ophthalmology

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“…Minocycline hydrochloride is a second‐generation tetracycline commonly prescribed in the treatment of acne vulgaris. Pigmentary changes of the skin, 1 nail bed, 2 teeth, 3 sclera, 4 thyroid, 5 substantia nigra, 5 atherosclerotic plaques, 5 oral mucosa, 6 conjunctival cysts, 7 bones, 8 tongue, 9,10 and skeletal muscle 11 have been reported with its use. In 1978, Basler and Kohnen 12 provided the first ultrastructural description of minocycline‐related hyperpigmentation.…”

Section: Discussionmentioning

confidence: 99%

Minocycline hyperpigmentation isolated to the subcutaneous fat

Rahman

Lazova²,

Antaya³

2005

J Cutan Pathol

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We present a 15-year-old girl with bilateral lower extremity discoloration of one-year duration while taking minocycline for acne vulgaris. The clinical characteristics best supported type II minocycline hyperpigmentation, but the histology revealed that the pigmentation was solely limited to the subcutaneous adipose tissue, completely sparing the dermis. Special stain for iron was negative. This is the first case to our knowledge with pigment exclusively located in the subcutaneous fat and with the unusual finding of a negative stain for iron.

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Pigmented Conjunctival Cysts Following Tetracycline/Minocycline Therapy

Cited by 42 publications

References 22 publications

Clinically Important Ocular Reactions to Systemic Drug Therapy

Clinically Important Ocular Reactions to Systemic Drug Therapy

Doxycycline‐associated conjunctival cysts

Minocycline hyperpigmentation isolated to the subcutaneous fat

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