Pigmentation abnormalities in systemic scleroderma examined by using a colorimeter (Choromo Meter CR-200)

Maeda, Manabu; Kachi, Hideki; Matubara, Katsutoshi; Mori, Shunji; Kitajima, Yasuo

doi:10.1016/0923-1811(95)00446-7

Cited by 10 publications

(7 citation statements)

References 11 publications

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“…In a number of previous studies [2,3,5,6,8], the L* value has been utilized as an index of skin pigmentation. However, there was only a weak correlation between the L* value and the melanin index detected in normal skin [7].…”

Section: Discussionmentioning

confidence: 99%

Usefulness of a Narrow-Band Reflectance Spectrophotometer in Evaluating Effects of Depigmenting Treatment

Yoshimura¹,

Harii²,

Masuda³

et al. 2001

Aesthetic Plastic Surgery

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Abstract. As a depigmenting treatment, combined topical applications of all-trans retinoic acid (atRA) aqueous gel and 5% hydroquinone, 7% lactic acid ointment were used for Oriental patients with hyperpigmented skin lesions such as senile lentigines and nevus spilus. A narrow-band reflectance spectrophotometer and a tristimulus colorimeter were used to evaluate objectively the intensity of pigmentation and erythema at each clinical visit. L*, a*, and b* values measured with a tristimulus colorimeter (Chroma Meter CR-300) enabled the evaluation of erythema but not pigmentation. On the other hand, the melanin and hemoglobin values measured with a narrow-band reflectance spectrophotometer (Mexameter MX-16) expressed both erythema and pigmentation well. It was revealed that, in our bleaching protocol, the narrow-band reflectance spectrophotometer was quite useful for estimating accurately the intensity of pigmentation and erythema and determining the best time point for the cessation of atRA treatment. Key words: Depigmenting treatment-Retinoic acid aqueous gel-Senile lentigines-Nevus spilusUsing our bleaching protocol with a high concentration of all-trans retinoic acid (atRA) aqueous gel in combination with hydroquinone and lactic acid, a remarkable improvement of various skin lesions with hyperpigmentation, such as senile lentigines [13], melasma, postinflammatory hyperpigmentation, and nevus spilus, was obtained with a short period of treatment [14]. However, during the treatment, side effects such as erythema were frequently observed after the topical application of atRA.Tristimulus colorimeters and full-range or narrowband spectrophotometers have been employed for the quantification of erythema and pigmentation induced by ultraviolet radiation (UVR) [7], and for the color analysis of skin lesions [9] or transferred skin [12]. We have used a tristimulus colorimeter and a narrow-band spectrophotometer to evaluate skin reactions such as the intensity of pigmentation and erythema in our bleaching treatment. Representative cases are demonstrated and the usefulness of the reflectance spectrophotometer is discussed. MethodsCombined topical applications of atRA, hydroquinone, and lactic acid were used for skin lesions with hyperpigmentation. atRA aqueous gel (atRA gel; 0.1, 0.2, and 0.4%) was originally prepared at the Department of Pharmacy, University of Tokyo. AtRA gel was topically applied together with 5% hydroquinone, 7% lactic acid ointment (HQ-LA ointment), also prepared as described above. Plastibase (petrolatum polyethylene ointment base; Taisho Pharmacology, Osaka, Japan) was used as the ointment base of HQ-LA ointment. Both atRA gel and HQ-LA ointments are pharmacologically unstable, so that fresh ointments were prepared at least once a month. Each ointment was topically applied under signed informed consent to more than 120 Oriental patients with hyperpigmented skin lesions such as sinile lentigines, melasma, postinflammatory hyperpigmentation, and nevus spilus.Treatment protocol. atRA gel was applied to...

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Section: Discussionmentioning

confidence: 99%

Usefulness of a Narrow-Band Reflectance Spectrophotometer in Evaluating Effects of Depigmenting Treatment

Yoshimura¹,

Harii²,

Masuda³

et al. 2001

Aesthetic Plastic Surgery

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“…Finally, abnormalities of skin pigmentation were one of the major symptoms suggesting scleroderma in our patients. Skin pigmentation disturbances are classically associated with the development of SSc . Depigmentation similar to vitiligo, localized hyperpigmentation or a combination of the two have been described in the presentation of SSc.…”

Section: Reportmentioning

confidence: 99%

“…Skin pigmentation disturbances are classically associated with the development of SSc. 2 Depigmentation similar to vitiligo, localized hyperpigmentation or a combination of the two have been described in the presentation of SSc. Fibroblasts are considered the culprit cell type in fibrosing tissue disorders, as their activation leads to the production of extracellular matrix components.…”

Section: Reportmentioning

confidence: 99%

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Pigmented skin patches without scleroderma as a predominant clinical symptom revealing systemic sclerosis

et al. 2015

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Skin induration remains the major clinical symptom of systemic sclerosis (SSc), an autoimmune disease with potentially life-threatening visceral involvement. However, skin induration can be absent in some patients, making the diagnosis difficult to confirm and leading to delay in management. Skin pigmentation abnormalities have been reported in patients with SSc, and can be important to recognize for diagnosis. We report two patients who developed hyperpigmented skin patches without any sign of scleroderma, as a major clinical skin symptom of incipient SSc.

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“…However, visual evaluation often makes communicating a particular colour or a difference between colours difficult and vague. Nowadays, the quantitative evaluations of skin colour have been achieved in many literatures using reflectance colorimetry [1][2] or colour image analysis [3]. In Taiwan, Kuo et al [4] have attempted to estimate the relativity between facial skin colour and symptom of Taiwan people for many years.…”

mentioning

confidence: 99%

The investigation on the skin whitening efficacy of Chinese herb extracts using the colour physics technology

Shu

Weng

Kuo

et al. 2005

Journal of Dermatological Science

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Pigmentation abnormalities in systemic scleroderma examined by using a colorimeter (Choromo Meter CR-200)

Cited by 10 publications

References 11 publications

Usefulness of a Narrow-Band Reflectance Spectrophotometer in Evaluating Effects of Depigmenting Treatment

Usefulness of a Narrow-Band Reflectance Spectrophotometer in Evaluating Effects of Depigmenting Treatment

Pigmented skin patches without scleroderma as a predominant clinical symptom revealing systemic sclerosis

The investigation on the skin whitening efficacy of Chinese herb extracts using the colour physics technology

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