2006
DOI: 10.1016/j.exer.2005.05.007
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Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration

Abstract: The purpose of this study was to examine the localization and relative levels of vascular endothelial growth factor (VEGF; an angiogenic factor) and pigment epithelium-derived factor (PEDF; an antiangiogenic factor) in aged human choroid and to determine if the localization or their relative levels changed in age-related macular degeneration (AMD). Ocular tissues were obtained from eight aged control donors (age range, 75-86 years; mean age, 79.8 years) with no evidence or history of chorioretinal disease and … Show more

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Cited by 239 publications
(195 citation statements)
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“…Further evidence that PEDF expression may reduce the likelihood of CNV is from immunohistochemistry of VEGF and PEDF in the RPE and choroid of eyes from AMD and control patients. Specifically, PEDF immunoreactivity was less in RPE/Bruch's membrane/choroid from patients who had had AMD than in age-matched controls (Bhutto et al, 2006). There is also evidence that some stresses, including hypoxia and oxidative stress, two factors associated with neovascular AMD and expression of VEGF, increase the VEGF/PEDF ratio tipping the balance of angiogenic stimulation/inhibition to favor the development of neurosensory retinal CNV.…”
Section: Vegf To Pedf Ratiomentioning
confidence: 99%
“…Further evidence that PEDF expression may reduce the likelihood of CNV is from immunohistochemistry of VEGF and PEDF in the RPE and choroid of eyes from AMD and control patients. Specifically, PEDF immunoreactivity was less in RPE/Bruch's membrane/choroid from patients who had had AMD than in age-matched controls (Bhutto et al, 2006). There is also evidence that some stresses, including hypoxia and oxidative stress, two factors associated with neovascular AMD and expression of VEGF, increase the VEGF/PEDF ratio tipping the balance of angiogenic stimulation/inhibition to favor the development of neurosensory retinal CNV.…”
Section: Vegf To Pedf Ratiomentioning
confidence: 99%
“…33,34 Recently, we reported a reduction of VEGF gene expression in the retina of OXYS rats compared to the parent Wistar strain (control) during retinopathy progression 12 ; this effect may be linked to the early alterations in RPE cells and choroid vessels in OXYS rats. We supposed that such changes are prerequisite to the development of retinopathy and that their reversal is necessary for the prevention of the disease.…”
Section: Discussionmentioning
confidence: 99%
“…4 In tissues from AMD patients, PEDF is significantly lower in RPE cells, the Bruch's membrane, and the choroid than in control eyes. These data suggest that a decrease in PEDF may disrupt the balance of these 2 factors and create a proangiogenic environment that promotes choroidal neovascularization.…”
Section: Genetically Altered Mouse Models Of Angiogenesismentioning
confidence: 99%
“…The apical aspect of RPE cells is intimately associated with photoreceptor outer segments (Figs. [3][4][5]. Photoreceptor outer segments are continually renewed from their base, and a major function of RPE cells is to remove oxidized outer-segment disc material.…”
Section: The Retinal Pigment Epitheliummentioning
confidence: 99%