“…Forty-three studies, 3 These included two reviews, 3,17 one randomized controlled trial (RCT) 12 and one study reported as an abstract. 83 Reasons for exclusion were: lack of information to calculate diagnostic accuracy of the index test (13 studies 8,12,50-60 ); selection bias -selective inclusion of the lesions (11 studies [61][62][63][64][65][66][67]69,78,82,84 ) and selective excision of the lesions (one study 84 ); histology not available (five studies 9,11,[70][71][72] ); test performed by experts and nonexperts but data not reported separately (two studies 10,13 ); study conducted as a training exercise (three studies [74][75][76] ); discussion of different diagnostic tools or parameters for melanoma diagnosis than stipulated in the review (four studies 68,77,79,80 ); use of the index test as a tool for follow-up of the atypical skin lesions rather than for diagnosis; 73 and discussion about limitations of dermoscopy. 81…”