2014
DOI: 10.1007/s10620-014-3044-3
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Piezo1 Is as a Novel Trefoil Factor Family 1 Binding Protein that Promotes Gastric Cancer Cell Mobility In Vitro

Abstract: Our data demonstrate that Piezo1 is a novel TFF1 binding protein that is important for TFF1-mediated cell migration and suggest that this interaction may be a therapeutic target in the invasion and metastasis of gastric cancer.

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Cited by 88 publications
(97 citation statements)
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“…Because it is down-regulated in many small cell lung cancer cell lines, loss of Piezo1 has been suggested to play a role in increased cell migration and distant metastases in lung cancer (50). In contrast, knockdown of Piezo1 in gastric tumor cell lines was associated with decreased cell migration (51). These studies, along with those from endothelial cells, implicate a role for Piezo proteins in cell migration, proliferation, and elongation.…”
Section: Role Of Piezo1 In Cell Migration Proliferation and Elongationmentioning
confidence: 90%
“…Because it is down-regulated in many small cell lung cancer cell lines, loss of Piezo1 has been suggested to play a role in increased cell migration and distant metastases in lung cancer (50). In contrast, knockdown of Piezo1 in gastric tumor cell lines was associated with decreased cell migration (51). These studies, along with those from endothelial cells, implicate a role for Piezo proteins in cell migration, proliferation, and elongation.…”
Section: Role Of Piezo1 In Cell Migration Proliferation and Elongationmentioning
confidence: 90%
“…cell migration and indicates that this interaction may be a therapeutic target in the invasion and metastasis of GC [31,118]. Interestingly, in normal lung epithelial cells, depletion of Piezo1 increases cell migration [118].…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…Page 5 enhancement of cell migration by TFF1 could provide an explanation for the apparent conflict that TFF1 expression is beneficial in normal tissues but detrimental in tumors [31]. In addition, TFF1 is involved in protecting the gastrointestinal mucosa from damage and repairing it through cell migration after injury [32,33].…”
Section: Accepted Manuscriptmentioning
confidence: 99%
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