Pickering emulsions stabilized by hydrophobically modified alginate nanoparticles: Preparation and pH-responsive performance in vitro

Zhang, Wenjun; Sun, Xiaohong; Fan, Xianlin; Li, Min; He, Gaohong

doi:10.1080/01932691.2017.1320223

Cited by 21 publications

(7 citation statements)

References 46 publications

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“…Another promising pH-responsive Pickering emulsion was described by Zhang et al [212]. They after 4h, proving that MCA stabilizing pH-sensitivity Pickering emulsions appears as a promising candidate for the controlled oral delivery of drug substances.…”

Section: Chitin/chitosan-based Particlesmentioning

confidence: 94%

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

Albert

Beladjine

Tsapis

et al. 2019

Journal of Controlled Release

305

243

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Section: Chitin/chitosan-based Particlesmentioning

confidence: 94%

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

Albert

Beladjine

Tsapis

et al. 2019

Journal of Controlled Release

305

243

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“…RES-ALA-CHI colloidal particles (5:1, ALA:CHI) exhibited the lowest Z-average diameters (286.7 nm and 211.2 nm) at both pHs (5.0 and 6.5) (p < 0.05). The addition of excessive CHI molecules would result in the excessive adsorption of CHI molecules on ALA molecules, which would contribute to the pronounced enhancement of mean particle size and PDI value ( Zhang, Sun, Fan, Li, & He, 2018 ). Moreover, bridging effects of CHI with ALA would result in the occurrence of complex coacervation through electrostatic interaction in the absence of sufficient CHI (10:1) ( Zhang et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

“…The addition of excessive CHI molecules would result in the excessive adsorption of CHI molecules on ALA molecules, which would contribute to the pronounced enhancement of mean particle size and PDI value ( Zhang, Sun, Fan, Li, & He, 2018 ). Moreover, bridging effects of CHI with ALA would result in the occurrence of complex coacervation through electrostatic interaction in the absence of sufficient CHI (10:1) ( Zhang et al, 2018 ). PDIs showed similar trends with mean particle sizes with the variations of the mass ratio.…”

Section: Resultsmentioning

confidence: 99%

Resveratrol-loaded α-lactalbumin-chitosan nanoparticle-encapsulated high internal phase Pickering emulsion for curcumin protection and its in vitro digestion profile

2022

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“…Biocompatible materials including polysaccharides like chitosan, [68,69] soy peptides, [70] lignin [71] and alginic acid [72,73] show excellent potential as emulsifiers and emulsifiermodification agents in stimuli-responsive Pickering emulsions. This is due to the abundance of pH-responsive functional groups in their structures, such as amines, hydroxyls, and carbonyls, which can cross-link and dissociate or decompose accordingly to stabilise or destabilise the emulsion systems.…”

Section: Ph Responsive Pickering Emulsionsmentioning

confidence: 99%

Recent developments in Pickering emulsions for biomedical applications

Harman

Patel

Guldin

et al. 2019

Current Opinion in Colloid & Interface Science

128

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Pickering emulsions, stabilised by organic or inorganic particles, offer long-term dispersibility of liquid droplets and resistance to coalescence. The versatility of stabilising particles and their ability to encapsulate and release cargo with high internal payload capacity makes them attractive in a wide variety of applications, ranging from catalysis to the cosmetic and food industry. While these properties make them an equally promising material platform for pharmaceutical and clinical applications, the development of Pickering emulsions for healthcare is still in its infancy. Herein, we summarise and discuss recent progress in the development of Pickering emulsions for biomedical applications, probing their design for passive diffusion-based release as well as stimuli-responsive destabilisation. We further comment on challenges and future directions of this exciting and rapidly expanding area of research.Pickering emulsions have been applied in a number of areas of research and industrial importance, such as food manufacturing, cosmetics, agrochemicals and therapeutic delivery. Their popularity in biomedical applications (i.e. for use in healthcare, such as therapeutics, diagnostics or imaging), in particular, has increased dramatically in recent years, thanks to their high stability, capacity for superior cargo loading compared to conventional systems, and diverse range of stabilising particles, creating a broad library of available building blocks. For biomedical and pharmaceutical application, the choice of emulsifier is critical; it must be biocompatible, non-toxic, and be able to be excreted from the body (if necessary). In this article, we will review the latest developments in the design and application of Pickering emulsions for biomedicine, with a focus on stimuli-responsive Pickering emulsions as a route to the triggered release of a payload towards advanced therapeutic delivery strategies. Within this discussion, we will describe systems which have been applied in proof of concept and in vitro assessments and emphasise areas of potential future development.

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Pickering emulsions stabilized by hydrophobically modified alginate nanoparticles: Preparation and pH-responsive performance in vitro

Cited by 21 publications

References 46 publications

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

Resveratrol-loaded α-lactalbumin-chitosan nanoparticle-encapsulated high internal phase Pickering emulsion for curcumin protection and its in vitro digestion profile

Recent developments in Pickering emulsions for biomedical applications

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