Phytotherapy in the Management of Diabetes: A Review

Governa, Paolo; Baini, Giulia; Borgonetti, Vittoria; Cettolin, Giulia; Giachetti, Daniela; Magnano, Anna Rosa; Miraldi, Elisabetta; Biagi, Marco

doi:10.3390/molecules23010105

Cited by 102 publications

(74 citation statements)

References 169 publications

(166 reference statements)

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“…Due to the side effects associated with currently available drugs, as well as their limited efficacy [7], in recent decades, the potential of natural products in combating MetS has aroused great interest in scientific research [8]. Natural products from plant and marine sources, including their isolated extracts or bioactive components, have been demonstrated to be effective in the prevention and treatment of MetS and its co-morbidities [9,10]. Brown algae ( Phaeophyceae ), rich in chlorophylls, sterols, carotenoids, and polyunsaturated fatty acids, have shown positive effects on health, such as anti-hyperglycemic activity, antioxidant properties, and anti-obesity capacity, in animal models [11].…”

Section: Introductionmentioning

confidence: 99%

Potential Usefulness of a Wakame/Carob Functional Snack for the Treatment of Several Aspects of Metabolic Syndrome: From In Vitro to In Vivo Studies

et al. 2018

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Metabolic syndrome (MetS) greatly increases the risk of cardiovascular diseases and type 2 diabetes mellitus. The aim of this study was to evaluate the efficacy of functional snacks containing a combination of wakame (W) and carob pod (CP) flours in reducing markers associated with MetS. The mechanisms of action underlying these effects were also evaluated. In vitro approaches were carried out in mature 3T3-L1 adipocytes and RAW 264.7 macrophages treated with different doses of extracts from W, CP, or a combination of both. Furthermore, an in vivo experiment was conducted in rats with MetS treated with normal-caloric diets containing different snack formulations with combinations of 1/50 (snack A) or 1/5 of wakame/carob (snack B). In vitro experiments results indicated that both W and CP had delipidating effects, but only the latter induced anti-inflammatory and anti-hypertensive effects. As far as the in vivo study is concerned, snack B was ineffective and snack A showed an anti-hypertensive effect in rats with MetS. The present study shows for the first time the in vitro efficacy of a W and CP combination as an anti-inflammatory, delipidating, and anti-hypertensive tool, and its potential usefulness in treating MetS.

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Section: Introductionmentioning

confidence: 99%

Potential Usefulness of a Wakame/Carob Functional Snack for the Treatment of Several Aspects of Metabolic Syndrome: From In Vitro to In Vivo Studies

et al. 2018

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“…Herbal remedies are very popular, particularly in developing countries, and play a supportive role as a complementary medical intervention with limited toxic effects and reduced financial cost. Over 400 plants and their compounds have been studied for type 2 DM treatment, and several reviews summarize these studies [23,24,25,26]. According to efficacy, the most active plants in the management of DM are Trigonella foenum greacum , Momordica charantia , Gymnema sylvestre , Ocimum tenuiflorum , Panax ginseng and quinquefolius , Coccinia grandis , Opuntia spp., Allium spp., etc.…”

Section: Therapeutic Potential Of Nutraceuticals Consumed In Type mentioning

confidence: 99%

“…According to efficacy, the most active plants in the management of DM are Trigonella foenum greacum , Momordica charantia , Gymnema sylvestre , Ocimum tenuiflorum , Panax ginseng and quinquefolius , Coccinia grandis , Opuntia spp., Allium spp., etc. [26,27,28]. Many studies in human and animal models of type 2 DM have confirmed the potential beneficial effects of plants to correct the metabolic disorder and to delay the development of diabetic complications.…”

Section: Therapeutic Potential Of Nutraceuticals Consumed In Type mentioning

confidence: 99%

Natural Hydrogen Sulfide Donors from Allium sp. as a Nutraceutical Approach in Type 2 Diabetes Prevention and Therapy

2019

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Type 2 diabetes mellitus (DM) is a socially relevant chronic disease with high prevalence worldwide. DM may lead to several vascular, macrovascular, and microvascular complications (cerebrovascular, coronary artery, and peripheral arterial diseases, retinopathy, neuropathy, and nephropathy), often accelerating the progression of atherosclerosis. Dietary therapy is generally considered to be the first step in the treatment of diabetic patients. Among the current therapeutic options, such as insulin therapy and hypoglycemic drugs, in recent years, attention has been shifting to the effects and properties—that are still not completely known—of medicinal plants as valid and inexpensive therapeutic supports with limited side effects. In this review, we report the relevant effects of medicinal plants and nutraceuticals in diabetes. In particular, we paid attention to the organosulfur compounds (OSCs) present in plant extracts that due to their antioxidant, hypoglycemic, anti-inflammatory, and immunomodulatory effects, can contribute as cardioprotective agents in type 2 DM. OSCs derived from garlic (Allium sp.), due to their properties, can represent a valuable support to the diet in type 2 DM, as outlined in this manuscript based on both in vitro and in vivo studies. Moreover, a relevant characteristic of garlic OSCs is their ability to produce the gasotransmitter H2S, and many of their effects can be explained by this property. Indeed, in recent years, several studies have demonstrated the relevant effects of endogenous and exogenous H2S in human DM, including by in vitro and in vivo experiments and clinical trials; therefore, here, we summarize the effects and the underlying molecular mechanisms of H2S and natural H2S donors.

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“…Phytotherapy is one of the most common and effective auxiliary methods in the treatment of type I and II diabetes mellitus [5,6]. If the disease can be detected in the early stages, phytotherapy in combination with a diet and dosed physical activity can stabilize the condition of many patients without drug treatment [7].…”

Section: Introductionmentioning

confidence: 99%

Selection of a Filler for Tablets Manufactured With Direct Compression Method Containing Dry Ginger Extract

Рубан

Alkhalaf

Гербіна

2019

EUREKA: Health Sciences

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The preliminary studies of physico-chemical and pharmaco-technological properties of the dry extract of ginger have determined the need for introduction of different groups of excipients for developing a solid dosage form for the treatment of type II diabetes mellitus. Aim. To choose the rational filler in the composition of tablets with ginger obtained by direct compression. Materials and methods. The study object was the dry extract of ginger (DEG) (producer “Megaprom”, Dnepr,Ukraine) and modern excipients for the production of tablets by direct compression: GalenIQ 721 (BENEO-Palatinit Gmb), Flowlac 100 (Meggle Co.), Tablettose 80 (Meggle Co.), Farmaxx (Merck), Microcelac 100 (Meggle Co.), Vivapur 112 and 102 (JRS Pharm), Prosolv HD 90, Prosolv SMCC 50 (JRS Pharm) manufactured in Germany. Pharmaco-technological and physico-chemical properties of the samples were studied according to conventional methods of the State Pharmacopoeia of Ukraine. Results and discussion. According to the results of the crystallographic analysis, the ability to the moisture absorption, resistance to crushing, disintegration time, fluidity indicators, angle of repose and bulk volume the effect of modern excipients on physicochemical and pharmaco-technological properties of the dry extract of ginger has been studied. Conclusions. According to the results of microscopic analysis, it has been found, that the rational fillers are GalenIQ 721, Prosolv HD 90, Prosolv SMCC 50, Vivapur 102 and Vivapur 112, as they provide a uniform system and the necessary resistance to destruction. The study of the kinetics of the moisture absorption has shown that addition of the fillers significantly reduces the increase in moisture compared to the dry extract. The mixture with GalenIQ 721 has the lowest parameters of moisture absorption at a relative air humidity of 45 %, 75 % and 100 %. In accordance with the results of the pharmaco-technological studies, it has been found that addition of GalenIQ 721 leads to improved flowability, disintegration, settling qualities; it indicates the feasibility of its inclusion into the composition of the solid dosage form.

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Phytotherapy in the Management of Diabetes: A Review

Cited by 102 publications

References 169 publications

Potential Usefulness of a Wakame/Carob Functional Snack for the Treatment of Several Aspects of Metabolic Syndrome: From In Vitro to In Vivo Studies

Potential Usefulness of a Wakame/Carob Functional Snack for the Treatment of Several Aspects of Metabolic Syndrome: From In Vitro to In Vivo Studies

Natural Hydrogen Sulfide Donors from Allium sp. as a Nutraceutical Approach in Type 2 Diabetes Prevention and Therapy

Selection of a Filler for Tablets Manufactured With Direct Compression Method Containing Dry Ginger Extract

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